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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005543naa a2200841 4500
001oai:lup.lub.lu.se:093a827e-00a0-4c14-a6d8-79f72bf4af79
003SwePub
008160401s2012 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-52851
0247 a https://lup.lub.lu.se/record/24098952 URI
0247 a https://doi.org/10.1093/carcin/bgr2852 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-528512 URI
040 a (SwePub)lud (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Duell, Eric J.4 aut
2451 0a Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
264 c 2011-12-05
264 1a Oxford :b Oxford University Press (OUP),c 2012
520 a Studies that have examined the association between alcohol consumption and gastric cancer (GC) risk have been inconsistent. We conducted an investigation of 29 genetic variants in alcohol metabolism loci (alcohol dehydrogenase, ADH1 gene cluster: ADH1A, ADH1B and ADH1C; ADH7 and aldehyde dehydrogenase, ALDH2), alcohol intake and GC risk. We analyzed data from a nested case-control study (364 cases and 1272 controls) within the European Prospective Investigation into Cancer and Nutrition cohort. Single nucleotide polymorphisms (SNPs) were genotyped using a customized array. We observed a statistically significant association between a common 3'-flanking SNP near ADH1A (rs1230025) and GC risk [allelic odds ratio (OR)(A v T) = 1.30, 95% confidence interval (CI) = 1.07-1.59]. Two intronic variants, one in ADH1C (rs283411) and one in ALDH2 (rs16941667), also were associated with GC risk (ORT v C = 0.59; 95% CI = 0.38-0.91 and ORT v C = 1.34; 95% CI = 1.00-1.79, respectively). Individuals carrying variant alleles at both ADH1 (rs1230025) and ALDH2 (rs16941667) were twice as likely to develop GC (ORA+T = 2.0; 95% CI = 1.25-3.20) as those not carrying variant alleles. The association between rs1230025 and GC was modified by alcohol intake (< 5 g/day: ORA = 0.89, 95% CI = 0.57-1.39; >= 5 g/day: ORA = 1.45, 95% CI = 1.08-1.94, P-value = 0.05). The association was also modified by ethanol intake from beer. A known functional SNP in ADH1B (rs1229984) was associated with alcohol intake (P-value = 0.04) but not GC risk. Variants in ADH7 were not associated with alcohol intake or GC risk. In conclusion, genetic variants at ADH1 and ALDH2 loci may influence GC risk, and alcohol intake may further modify the effect of ADH1 rs1230025. Additional population-based studies are needed to confirm our results.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Sala, Nuria4 aut
7001 a Travier, Noemie4 aut
7001 a Munoz, Xavier4 aut
7001 a Christine Boutron-Ruault, Marie4 aut
7001 a Clavel-Chapelon, Francoise4 aut
7001 a Barricarte, Aurelio4 aut
7001 a Arriola, Larraitz4 aut
7001 a Navarro, Carmen4 aut
7001 a Sanchez-Cantalejo, Emilio4 aut
7001 a Ramon Quiros, J.4 aut
7001 a Krogh, Vittorio4 aut
7001 a Vineis, Paolo4 aut
7001 a Mattiello, Amalia4 aut
7001 a Tumino, Rosario4 aut
7001 a Khaw, Kay-Tee4 aut
7001 a Wareham, Nicholas4 aut
7001 a Allen, Naomi E.4 aut
7001 a Peeters, Petra H.4 aut
7001 a Numans, Mattijs E.4 aut
7001 a Bueno-de-Mesquita, H. B.4 aut
7001 a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001
7001 a Bamia, Christina4 aut
7001 a Benetou, Vassiliki4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Canzian, Federico4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Boeing, Heiner4 aut
7001 a Bergmann, Manuela M.4 aut
7001 a Lund, Eiliv4 aut
7001 a Ehrnström, Royu Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)pat-reh
7001 a Johansen, Dortheu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kirm-djo
7001 a Hallmans, Goran4 aut
7001 a Stenling, Rogeru Umeå universitet,Patologi4 aut0 (Swepub:umu)rost0001
7001 a Tjonneland, Anne4 aut
7001 a Overvad, Kim4 aut
7001 a Ostergaard, Jane Nautrup4 aut
7001 a Ferrari, Pietro4 aut
7001 a Fedirko, Veronika4 aut
7001 a Jenab, Mazda4 aut
7001 a Nesi, Gabriella4 aut
7001 a Riboli, Elio4 aut
7001 a Gonzalez, Carlos A.4 aut
7102 a Umeå universitetb Näringsforskning4 org
7730 t Carcinogenesisd Oxford : Oxford University Press (OUP)g 33:2, s. 361-367q 33:2<361-367x 0143-3334x 1460-2180
8564 u http://dx.doi.org/10.1093/carcin/bgr285y FULLTEXT
8564 u https://academic.oup.com/carcin/article-pdf/33/2/361/7459302/bgr285.pdf
8564 8u https://lup.lub.lu.se/record/2409895
8564 8u https://doi.org/10.1093/carcin/bgr285
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-52851

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