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Intestinal Microbio...
Intestinal Microbiome in Hematopoietic Stem Cell Transplantation For Autoimmune Diseases : Considerations and Perspectives on Behalf of Autoimmune Diseases Working Party (ADWP) of the EBMT
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- Alexander, Tobias (författare)
- Charite Univ Med Berlin, Dept Rheumatol & Clin Immunol, Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Berlin Inst Hlth BIH, Berlin, Germany.;Deutsch Rheuma Forschungszentrum DRFZ Berlin, Berlin, Germany.
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- Snowden, John A. (författare)
- Sheffield Teaching Hospitals Fdn NHS Trust, Dept Haematol, Sheffield, S Yorkshire, England.;Univ Sheffield, Dept Oncol & Metab, Sheffield, S Yorkshire, England.
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- Burman, Joachim, 1974- (författare)
- Uppsala universitet,Landtblom: Neurovetenskap
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- Chang, Hyun-Dong (författare)
- Deutsch Rheuma Forschungszentrum DRFZ Berlin, Berlin, Germany.;Tech Univ Berlin, Inst Biotechnol, Berlin, Germany.
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- Del Papa, Nicoletta (författare)
- ASST G PiniCTO, Dip Reumatol, Scleroderma Clin, Milan, Italy.
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- Farge, Dominique (författare)
- CRMR MATHEC, Malad AutoImmunes & Therapie Cellulaire, Unite Med Interne UF 04, Paris, France.;Univ Paris, IRSL, Rech Clin Appl Hematol, Paris, France.;McGill Univ, Dept Med, Montreal, PQ, Canada.
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- Lindsay, James O. (författare)
- Queen Mary Univ London, Blizard Inst, Ctr Immunobiol, Barts & London Sch Med, London, England.
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- Malard, Florent (författare)
- Sorbonne Univ, Serv Hematol Clin & Therapie Cellulaire, Hop St Antoine, AP HP,INSERM,UMRs 938, Paris, France.
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- Muraro, Paolo A. (författare)
- Imperial Coll London, Dept Brain Sci, London, England.
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- Nitti, Rosamaria (författare)
- Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst, Unit Hematol & Bone Marrow Transplantat, Milan, Italy.
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- Salas, Azucena (författare)
- IDIBAPS, CIBER, EHD, Barcelona, Spain.
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- Sharrack, Basil (författare)
- Sheffield Teaching Hosp NHS, Dept Neurosci, Fdn Trust, Sheffield, S Yorkshire, England.;Univ Sheffield, NIHR Neurosci BioMed Res Ctr, Sheffield, S Yorkshire, England.
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- Mohty, Mohamad (författare)
- Sorbonne Univ, Serv Hematol Clin & Therapie Cellulaire, Hop St Antoine, AP HP,INSERM,UMRs 938, Paris, France.
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- Greco, Raffaella (författare)
- Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst, Unit Hematol & Bone Marrow Transplantat, Milan, Italy.
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Charite Univ Med Berlin, Dept Rheumatol & Clin Immunol, Berlin, Germany;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Berlin Inst Hlth BIH, Berlin, Germany.;Deutsch Rheuma Forschungszentrum DRFZ Berlin, Berlin, Germany. Sheffield Teaching Hospitals Fdn NHS Trust, Dept Haematol, Sheffield, S Yorkshire, England.;Univ Sheffield, Dept Oncol & Metab, Sheffield, S Yorkshire, England. (creator_code:org_t)
- 2021-10-22
- 2021
- Engelska.
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Ingår i: Frontiers in Oncology. - : Frontiers Media S.A.. - 2234-943X. ; 11
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Over the past decades, hematopoietic stem cell transplantation (HSCT) has been evolving as specific treatment for patients with severe and refractory autoimmune diseases (ADs), where mechanistic studies have provided evidence for a profound immune renewal facilitating the observed beneficial responses. The intestinal microbiome plays an important role in host physiology including shaping the immune repertoire. The relationships between intestinal microbiota composition and outcomes after HSCT for hematologic diseases have been identified, particularly for predicting the mortality from infectious and non-infectious causes. Furthermore, therapeutic manipulations of the gut microbiota, such as fecal microbiota transplant (FMT), have emerged as promising therapeutic approaches for restoring the functional and anatomical integrity of the intestinal microbiota post-transplantation. Although changes in the intestinal microbiome have been linked to various ADs, studies investigating the effect of intestinal dysbiosis on HSCT outcomes for ADs are scarce and require further attention. Herein, we describe some of the landmark microbiome studies in HSCT recipients and patients with chronic ADs, and discuss the challenges and opportunities of microbiome research for diagnostic and therapeutic purposes in the context of HSCT for ADs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- autoimmune diseases
- autoimmunity
- fecal transplantation
- intestinal
- microbiome
- stem cell transplantation
- HSCT = hematopoietic stem cell transplant
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Alexander, Tobia ...
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Snowden, John A.
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Burman, Joachim, ...
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Chang, Hyun-Dong
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Del Papa, Nicole ...
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Farge, Dominique
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Lindsay, James O ...
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Malard, Florent
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Muraro, Paolo A.
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Nitti, Rosamaria
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Salas, Azucena
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Sharrack, Basil
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Mohty, Mohamad
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Greco, Raffaella
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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Frontiers in Onc ...
- Av lärosätet
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Uppsala universitet