WFRF:(Paulsen M.)
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Immunohistochemical changes in the expression of HSP27 in exercised human vastus lateralis muscle
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- Folkesson, Mattias, 1972- (author)
- Örebro universitet,Hälsoakademin,RISPA
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- Mackey, A. L. (author)
- Institute of Sports Medicine, Bispebjerg Hospital and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
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- Holm, L. (author)
- Institute of Sports Medicine, Bispebjerg Hospital and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
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- (creator_code:org_t)
- Blackwell Publishing, 2008
- 2008
- English.
- In: Acta Physiologica. - : Blackwell Publishing. - 1748-1708 .- 1748-1716. ; 194:3, s. 215-222
- Journal article (peer-reviewed)
Abstract
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- Aim: The role of HSP27 in the adaptive process of skeletal muscle to exercise, especially in humans, is not well understood. The objective of this study was to investigate immunohistochemical changes in HSP27 expression in human vastus lateralis muscle following resistance and endurance exercises.Methods: Two different exercise protocols were used: (1) one-leg ergometer cycling (EC, n = 6) consisting of two 30-min bouts at 40% and 75% of peak oxygen uptake, respectively, and (2) leg extension resistance exercise (RE, n = 9) including 10 sets of eight repetitions at a load corresponding to 70% of one maximal repetition (1RM). Immunohistochemistry using specific monoclonal antibodies was used to determine the location of HSP27 protein in muscle biopsies from human vastus lateralis.Results: Our results show that RE, but not EC, induced a significant appearance of scattered accumulations of HSP27 protein in muscle fibres from five of nine subjects. The number of fibres with accumulation of HSP27 in RE ranged from 0% to 32% with a mean of 6.3% of the total number of fibres.Conclusion: We conclude that this rapid HSP27 protein relocation after RE is an important player in the cellular remodelling of human muscle fibres in response to exercise involving high-force contractions, but not in response to endurance exercises.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- adaptation
- endurance and resistance exercise
- fibre type
- heat shock protein
- stress response
- MEDICINE
- MEDICIN
- Physiology
- Fysiologi
- Fysiologi
- Physiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Kjaer, M.
- Paulsen, G.
- Raastad, T.
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- Henriksson, J.
- Kadi, Fawzi, 197 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
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- Örebro University
- Karolinska Institutet
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