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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 08142naa a2202173 4500 | |
| 001 | oai:gup.ub.gu.se/300001 | |
| 003 | SwePub | |
| 008 | 240528s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3000012 URI |
| 024 | 7 | a https://doi.org/10.1038/s41588-020-00725-72 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bakker, M. K.4 aut |
| 245 | 1 0 | a Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors |
| 264 | c 2020-11-16 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2020 |
| 520 | a Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between ruptured and unruptured intracranial aneurysms. We also find a suggestive role for endothelial cells by using gene mapping and heritability enrichment. Drug-target enrichment shows pleiotropy between intracranial aneurysms and antiepileptic and sex hormone drugs, providing insights into intracranial aneurysm pathophysiology. Finally, genetic risks for smoking and high blood pressure, the two main clinical risk factors, play important roles in intracranial aneurysm risk, and drive most of the genetic correlation between intracranial aneurysms and other cerebrovascular traits. Cross-ancestry genome-wide association analyses in individuals of European and East Asian ancestry identify 11 new risk loci for intracranial aneurysms and highlight a polygenic architecture explaining a substantial fraction of disease heritability. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a ld score regression | |
| 653 | a subarachnoid hemorrhage | |
| 653 | a gwas | |
| 653 | a metaanalysis | |
| 653 | a sex | |
| 653 | a heritability | |
| 653 | a variants | |
| 653 | a smoking | |
| 653 | a patient | |
| 653 | a growth | |
| 653 | a Genetics & Heredity | |
| 700 | 1 | a van der Spek, R. A. A.4 aut |
| 700 | 1 | a van Rheenen, W.4 aut |
| 700 | 1 | a Morel, S.4 aut |
| 700 | 1 | a Bourcier, R.4 aut |
| 700 | 1 | a Hostettler, I. C.4 aut |
| 700 | 1 | a Alg, V. S.4 aut |
| 700 | 1 | a van Eijk, K. R.4 aut |
| 700 | 1 | a Koido, M.4 aut |
| 700 | 1 | a Akiyama, M.4 aut |
| 700 | 1 | a Terao, C.4 aut |
| 700 | 1 | a Matsuda, K.4 aut |
| 700 | 1 | a Walters, R. G.4 aut |
| 700 | 1 | a Lin, K.4 aut |
| 700 | 1 | a Li, L. M.4 aut |
| 700 | 1 | a Millwood, I. Y.4 aut |
| 700 | 1 | a Chen, Z. M.4 aut |
| 700 | 1 | a Rouleau, G. A.4 aut |
| 700 | 1 | a Zhou, S. R.4 aut |
| 700 | 1 | a Rannikmae, K.4 aut |
| 700 | 1 | a Sudlow, C. L. M.4 aut |
| 700 | 1 | a Houlden, H.4 aut |
| 700 | 1 | a van den Berg, L. H.4 aut |
| 700 | 1 | a Dina, C.4 aut |
| 700 | 1 | a Naggara, O.4 aut |
| 700 | 1 | a Gentric, J. C.4 aut |
| 700 | 1 | a Shotar, E.4 aut |
| 700 | 1 | a Eugene, F.4 aut |
| 700 | 1 | a Desal, H.4 aut |
| 700 | 1 | a Winsvold, B. S.4 aut |
| 700 | 1 | a Borte, S.4 aut |
| 700 | 1 | a Johnsen, M. B.4 aut |
| 700 | 1 | a Brumpton, B.4 aut |
| 700 | 1 | a Sandvei, M. S.4 aut |
| 700 | 1 | a Willer, C. J.4 aut |
| 700 | 1 | a Hveem, K.4 aut |
| 700 | 1 | a Zwart, J. A.4 aut |
| 700 | 1 | a Verschuren, W. M. M.4 aut |
| 700 | 1 | a Friedrich, C. M.4 aut |
| 700 | 1 | a Hirsch, S.4 aut |
| 700 | 1 | a Schilling, S.4 aut |
| 700 | 1 | a Dauvillier, J. M.4 aut |
| 700 | 1 | a Martin, O.4 aut |
| 700 | 1 | a Winsvold, B. S.4 aut |
| 700 | 1 | a Winsvold, B. S.4 aut |
| 700 | 1 | a Borte, S.4 aut |
| 700 | 1 | a Johnsen, M. B.4 aut |
| 700 | 1 | a Brumpton, B. M.4 aut |
| 700 | 1 | a Sandvei, M. S.4 aut |
| 700 | 1 | a Willer, C. J.4 aut |
| 700 | 1 | a Hveem, K.4 aut |
| 700 | 1 | a Zwart, J. A.4 aut |
| 700 | 1 | a Bian, Z.4 aut |
| 700 | 1 | a Chen, J. S.4 aut |
| 700 | 1 | a Chen, Y. P.4 aut |
| 700 | 1 | a Chen, Z. M.4 aut |
| 700 | 1 | a Clarke, R.4 aut |
| 700 | 1 | a Collins, R.4 aut |
| 700 | 1 | a Guo, Y.4 aut |
| 700 | 1 | a Han, X.4 aut |
| 700 | 1 | a Hill, M.4 aut |
| 700 | 1 | a Li, L. M.4 aut |
| 700 | 1 | a Lin, K.4 aut |
| 700 | 1 | a Liu, D. P.4 aut |
| 700 | 1 | a Lv, J.4 aut |
| 700 | 1 | a Millwood, I.4 aut |
| 700 | 1 | a Peto, R.4 aut |
| 700 | 1 | a Sansome, S.4 aut |
| 700 | 1 | a Walters, R.4 aut |
| 700 | 1 | a Yang, X. M.4 aut |
| 700 | 1 | a Yu, C. Q.4 aut |
| 700 | 1 | a Koido, M.4 aut |
| 700 | 1 | a Koido, M.4 aut |
| 700 | 1 | a Akiyama, M.4 aut |
| 700 | 1 | a Terao, C.4 aut |
| 700 | 1 | a Matsuda, K.4 aut |
| 700 | 1 | a Kamatani, Y.4 aut |
| 700 | 1 | a Desal, H.4 aut |
| 700 | 1 | a Desal, H.4 aut |
| 700 | 1 | a Bourcier, R.4 aut |
| 700 | 1 | a Redon, R.4 aut |
| 700 | 1 | a Dina, C.4 aut |
| 700 | 1 | a Naggara, O.4 aut |
| 700 | 1 | a Eugene, F.4 aut |
| 700 | 1 | a Gentric, J. C.4 aut |
| 700 | 1 | a Shotar, E.4 aut |
| 700 | 1 | a Sargurupremraj, Muralidharan4 aut |
| 700 | 1 | a Tatlisumak, Turgutu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xtatlt |
| 700 | 1 | a Debette, S.4 aut |
| 700 | 1 | a Werring, D. J.4 aut |
| 700 | 1 | a Houlden, H.4 aut |
| 700 | 1 | a Alg, V. S.4 aut |
| 700 | 1 | a Hostettler, I. C.4 aut |
| 700 | 1 | a Bonner, S.4 aut |
| 700 | 1 | a Walsh, D.4 aut |
| 700 | 1 | a Bulters, D.4 aut |
| 700 | 1 | a Kitchen, N.4 aut |
| 700 | 1 | a Brown, M.4 aut |
| 700 | 1 | a Grieve, J.4 aut |
| 700 | 1 | a Bourcier, R.4 aut |
| 700 | 1 | a Walters, R. G.4 aut |
| 700 | 1 | a Malik, R.4 aut |
| 700 | 1 | a Dichgans, M.4 aut |
| 700 | 1 | a Sargurupremraj, M.4 aut |
| 700 | 1 | a Tatlisumak, T.4 aut |
| 700 | 1 | a Debette, S.4 aut |
| 700 | 1 | a Rinkel, G. J. E.4 aut |
| 700 | 1 | a Worrall, B. B.4 aut |
| 700 | 1 | a Pera, J.4 aut |
| 700 | 1 | a Slowik, A.4 aut |
| 700 | 1 | a Broderick, J. P.4 aut |
| 700 | 1 | a Werring, D. J.4 aut |
| 700 | 1 | a Woo, D.4 aut |
| 700 | 1 | a Bijlenga, P.4 aut |
| 700 | 1 | a Kamatani, Y.4 aut |
| 700 | 1 | a Ruigrok, Y. M.4 aut |
| 700 | 1 | a Jones, G. T.4 aut |
| 700 | 1 | a Bown, M. J.4 aut |
| 700 | 1 | a Ko, N. E. U.4 aut |
| 700 | 1 | a Kim, H.4 aut |
| 700 | 1 | a Coleman, J. R. I.4 aut |
| 700 | 1 | a Breen, G.4 aut |
| 700 | 1 | a Zaroff, J. G.4 aut |
| 700 | 1 | a Klijn, C. J. M.4 aut |
| 700 | 1 | a Malik, R.4 aut |
| 700 | 1 | a Dichgans, M.4 aut |
| 700 | 1 | a Sargurupremraj, M.4 aut |
| 700 | 1 | a Tatlisumak, T.4 aut |
| 700 | 1 | a Amouyel, P.4 aut |
| 700 | 1 | a Debette, S.4 aut |
| 700 | 1 | a Rinkel, G. J. E.4 aut |
| 700 | 1 | a Worrall, B. B.4 aut |
| 700 | 1 | a Pera, J.4 aut |
| 700 | 1 | a Slowik, A.4 aut |
| 700 | 1 | a Gaal-Paavola, E. I.4 aut |
| 700 | 1 | a Niemela, M.4 aut |
| 700 | 1 | a Jaaskelainen, J. E.4 aut |
| 700 | 1 | a Zu Fraunberg, M. V.4 aut |
| 700 | 1 | a Lindgren, A.4 aut |
| 700 | 1 | a Broderick, J. P.4 aut |
| 700 | 1 | a Werring, D. J.4 aut |
| 700 | 1 | a Woo, D.4 aut |
| 700 | 1 | a Redon, R.4 aut |
| 700 | 1 | a Bijlenga, P.4 aut |
| 700 | 1 | a Kamatani, Y.4 aut |
| 700 | 1 | a Veldink, J. H.4 aut |
| 700 | 1 | a Ruigrok, Y. M.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap4 org |
| 773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 52:12, s. 1303-1313q 52:12<1303-1313x 1061-4036x 1546-1718 |
| 856 | 4 | u https://europepmc.org/articles/pmc7116530?pdf=render |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/300001 |
| 856 | 4 8 | u https://doi.org/10.1038/s41588-020-00725-7 |
Hitta mer i SwePub
- Av författaren/redakt...
- Bakker, M. K.
- van der Spek, R. ...
- van Rheenen, W.
- Morel, S.
- Bourcier, R.
- Hostettler, I. C ...
- visa fler...
- Alg, V. S.
- van Eijk, K. R.
- Koido, M.
- Akiyama, M.
- Terao, C.
- Matsuda, K.
- Walters, R. G.
- Lin, K.
- Li, L. M.
- Millwood, I. Y.
- Chen, Z. M.
- Rouleau, G. A.
- Zhou, S. R.
- Rannikmae, K.
- Sudlow, C. L. M.
- Houlden, H.
- van den Berg, L. ...
- Dina, C.
- Naggara, O.
- Gentric, J. C.
- Shotar, E.
- Eugene, F.
- Desal, H.
- Winsvold, B. S.
- Borte, S.
- Johnsen, M. B.
- Brumpton, B.
- Sandvei, M. S.
- Willer, C. J.
- Hveem, K.
- Zwart, J. A.
- Verschuren, W. M ...
- Friedrich, C. M.
- Hirsch, S.
- Schilling, S.
- Dauvillier, J. M ...
- Martin, O.
- Brumpton, B. M.
- Bian, Z.
- Chen, J. S.
- Chen, Y. P.
- Clarke, R.
- Collins, R.
- Guo, Y.
- Han, X.
- Hill, M.
- Liu, D. P.
- Lv, J.
- Millwood, I.
- Peto, R.
- Sansome, S.
- Walters, R.
- Yang, X. M.
- Yu, C. Q.
- Kamatani, Y.
- Redon, R.
- Sargurupremraj, ...
- Tatlisumak, Turg ...
- Debette, S.
- Werring, D. J.
- Bonner, S.
- Walsh, D.
- Bulters, D.
- Kitchen, N.
- Brown, M.
- Grieve, J.
- Malik, R.
- Dichgans, M.
- Sargurupremraj, ...
- Tatlisumak, T.
- Rinkel, G. J. E.
- Worrall, B. B.
- Pera, J.
- Slowik, A.
- Broderick, J. P.
- Woo, D.
- Bijlenga, P.
- Ruigrok, Y. M.
- Jones, G. T.
- Bown, M. J.
- Ko, N. E. U.
- Kim, H.
- Coleman, J. R. I ...
- Breen, G.
- Zaroff, J. G.
- Klijn, C. J. M.
- Amouyel, P.
- Gaal-Paavola, E. ...
- Niemela, M.
- Jaaskelainen, J. ...
- Zu Fraunberg, M. ...
- Lindgren, A.
- Veldink, J. H.
- visa färre...
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