Psychosocial health modifies associations between HPA-axis function and brain structure in older age

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Fältnamn	Indikatorer	Metadata
000		05804naa a2200481 4500
001		oai:DiVA.org:uu-507545
003		SwePub
008		230707s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5075452 URI
024	7	a https://doi.org/10.1016/j.psyneuen.2023.1061062 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a van der Velpen, Isabelle F.u Erasmus MC Univ Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.;Erasmus MC Univ Med Ctr, Dept Radiol & Nucl Med, POB 2040, NL-3000 CA Rotterdam, Netherlands.4 aut
245	1 0	a Psychosocial health modifies associations between HPA-axis function and brain structure in older age
264	1	b Elsevier,c 2023
338		a electronic2 rdacarrier
520		a Background: Dysregulation of the negative feedback loop of the hypothalamic-pituitary-adrenal (HPA) axis may have damaging effects on the brain, potentially under influence of psychosocial health factors. We studied associations between functioning of the negative feedback loop of HPA-axis, measured with a very low-dose dexamethasone suppression test (DST), and brain structure in middle-aged and older adults, and whether these associations were modified by psychosocial health.Methods: From 2006 to 2008, 1259 participants (mean age 57.6 +/- 6.4, 59.6 % female) of the population-based Rotterdam Study completed a very low-dose DST (0.25 mg) and underwent magnetic resonance imaging (MRI) of the brain. Self-reported psychosocial health (depressive symptoms, loneliness, marital status, perceived social support) were assessed in the same time period. Multivariable linear and logistic regression were used to study cross-sectional associations between cortisol response and brain volumetrics, cerebral small vessel disease markers and white matter structural integrity. To assess the effect of psychosocial health on these associations, analyses were further stratified for psychosocial health markers.Results: Cortisol response was not associated with markers of global brain structure in the overall study sample. However, in participants with clinically relevant depressive symptoms, a diminished cortisol response was associated with smaller white matter volume (mean difference: - 1.00 mL, 95 %CI = - 1.89;- 0.10) and smaller white matter hyperintensity volume (mean difference: - 0.03 mL (log), 95 %CI = - 0.05;0.00). In participants with low/moderate perceived social support compared to those with high social support, a diminished cortisol response was associated with larger gray matter volume (mean difference: 0.70 mL, 95 %CI = 0.01;1.39) and higher fractional anisotropy (standardized mean difference 0.03, 95 %CI = 0.00;0.06).Conclusion: Diminished function of the HPA-axis is differently associated with brain structure in communitydwelling middle-aged and older adults with clinically relevant depressive symptoms or suboptimal social support, but not in adults without depressive symptoms or with optimal social support.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653		a HPA-axis
653		a Dexamethasone suppression test
653		a Magnetic resonance imaging
653		a Brain structure
653		a Social support
653		a Depression
700	1	a de Feijter, Maudu Erasmus MC Univ Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.4 aut
700	1	a Raina, Rutikau Emory Univ, Rollins Sch Publ Hlth, 1518 Clifton Rd, Atlanta, GA 30322 USA.;OPEN Hlth, 4350 East West Highway,Suite 1100, Bethesda, MD 20814 USA.4 aut
700	1	a Özel, Fatihu Uppsala universitet,Institutionen för organismbiologi,Miljötoxikologi4 aut0 (Swepub:uu)fatoz136
700	1	a Perry, Mariekeu Radboud Univ Nijmegen Med Ctr, Radboudumc Alzheimer Ctr, Dept Geriatr Med, POB 9101, NL-6500 HB Nijmegen, Netherlands.;Radboud Univ Nijmegen Med Ctr, Dept Primary & Community Care, POB 9101, NL-6500 HB Nijmegen, Netherlands.4 aut
700	1	a Ikram, M. Arfanu Erasmus MC Univ Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.4 aut
700	1	a Vernooij, Meike W.u Erasmus MC Univ Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.;Erasmus MC Univ Med Ctr, Dept Radiol & Nucl Med, POB 2040, NL-3000 CA Rotterdam, Netherlands.4 aut
700	1	a Luik, Annemarie I.u Erasmus MC Univ Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.;Erasmus MC Univ Med Ctr, Dept Child & Adolescent Psychiat Psychol, POB 2040, NL-3000 CA Rotterdam, Netherlands.;Erasmus MC, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.4 aut
710	2	a Erasmus MC Univ Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.;Erasmus MC Univ Med Ctr, Dept Radiol & Nucl Med, POB 2040, NL-3000 CA Rotterdam, Netherlands.b Erasmus MC Univ Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.4 org
773	0	t Psychoneuroendocrinologyd : Elsevierg 153q 153x 0306-4530x 1873-3360
856	4	u https://doi.org/10.1016/j.psyneuen.2023.106106y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1781343/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-507545
856	4 8	u https://doi.org/10.1016/j.psyneuen.2023.106106

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Av författaren/redakt...: van der Velpen, ...; de Feijter, Maud; Raina, Rutika; Özel, Fatih; Perry, Marieke; Ikram, M. Arfan; visa fler...; Vernooij, Meike ...; Luik, Annemarie ...; visa färre...

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