WFRF:(Persson Ann Maj)
Sökning: WFRF:(Persson Ann Maj) > The tetraspanin CD6...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04291naa a2200361 4500 | |
| 001 | oai:lup.lub.lu.se:d4d502cc-9b6f-4aae-853b-f4c4074cf45e | |
| 003 | SwePub | |
| 008 | 160404s2008 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/12236252 URI |
| 024 | 7 | a https://doi.org/10.1182/blood-2007-10-1162852 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Källquist, Lindau Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)hema-lka |
| 245 | 1 0 | a The tetraspanin CD63 is involved in granule targeting of neutrophil elastase. |
| 264 | 1 | b American Society of Hematology,c 2008 |
| 520 | a Targeting mechanisms of neutrophil elastase (NE) and other luminal proteins stored in myeloperoxidase (MPO)-positive secretory lysosomes/primary granules of neutrophils are unknown. These granules contain an integral membrane protein, CD63 with an adaptor protein-3-dependent granule delivery system. Therefore, we hypothesized that CD63 cooperates in granule delivery of the precursor of NE (proNE). Supporting this hypothesis, an association was demonstrated between CD63 and proNE upon coexpression in COS cells. This also involved augmented cellular retention of proNE requiring intact large extracellular loop of CD63. Furthermore, depletion of CD63 in promyelocytic HL-60 cells with RNA interference or a CD63 mutant caused reduction of cellular NE. However, the proNE steady state level was similar to wild type in CD63-depleted clones making it feasible to examine possible effects of CD63 on NE trafficking. Thus, depletion of CD63 led to reduced processing of proNE into mature NE and reduced constitutive secretion. Furthermore, CD63 -depleted cells showed a lack of morphologically normal granules, but contained MPO-positive cytoplasmic vacuoles with a lack of proNE and NE. Collectively, our data suggest that granule proteins may cooperate in targeting; CD63 can be involved in ER or Golgi export, cellular retention and granule targeting of proNE before storage as mature NE. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
| 700 | 1 | a Hansson, Markusu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)hema-mha |
| 700 | 1 | a Persson, Ann-Maju Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)efor-amp |
| 700 | 1 | a Janssen, Hans4 aut |
| 700 | 1 | a Calafat, Jero4 aut |
| 700 | 1 | a Tapper, Hansu Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)medk-hta |
| 700 | 1 | a Olsson, Ingeu Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)efor-iol |
| 710 | 2 | a Avdelningen för hematologi och transfusionsmedicinb Institutionen för laboratoriemedicin4 org |
| 773 | 0 | t Bloodd : American Society of Hematologyg 112, s. 3444-3454q 112<3444-3454x 1528-0020x 0006-4971 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/18669870?dopt=Abstractx freey FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1182/blood-2007-10-116285x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1223625 |
| 856 | 4 8 | u https://doi.org/10.1182/blood-2007-10-116285 |
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- Källquist, Linda
- Hansson, Markus
- Persson, Ann-Maj
- Janssen, Hans
- Calafat, Jero
- Tapper, Hans
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- Olsson, Inge
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