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Development of hepa...
Development of hepatic CYP1A and blood vitellogenin in eel (Anguilla anguilla) for use as biomarkers in the Thames Estuary, UK.
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Livingstone, D R (author)
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Mitchelmore, C L (author)
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Peters, L D (author)
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O'Hara, S C (author)
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Shaw, J P (author)
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Chesman, B S (author)
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Doyotte, A (author)
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McEvoy, J (author)
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- Ronisz, Dan (author)
- Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology
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- Larsson, D. G. Joakim, 1969 (author)
- Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology
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- Förlin, Lars, 1950 (author)
- Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology
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(creator_code:org_t)
- 2002
- 2002
- English.
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In: Marine environmental research. - 0141-1136. ; 50:1-5, s. 367-71
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The potential of eel (Anguilla anguilla) as a monitoring species for the Thames Estuary, UK, was examined. Hepatic cytochrome P4501A [7-ethoxyresorufin O-deethylase (EROD) activity] and blood vitellogenin (Western analysis) were investigated as biomarkers of exposure to, respectively, organic contaminants and to contaminants showing estrogenic activity. Hepatic microsomal EROD activities in A. anguilla from seven sites in the Thames Estuary in May 1998 varied three-fold (111 +/- 24 to 355 +/- 42 pmol min-1 mg protein-1) (mean +/- S.E.M.) and showed correlation with salinity; however, the latter relationship was not maintained at other times of the year. The range of EROD activities was two- to eight-fold higher than the 37 +/- 8 pmol min-1 mg-1 for A. anguilla from the relatively clean Tamar Estuary. beta-Naphthoflavone treatment (5 mg kg-1 wet wt.; 2 days) of Thames A. anguilla produced a two-fold increase in hepatic microsomal EROD activity. Comparing the Thames EROD data with those for A. anguilla from well-characterised contaminated sites in the Netherlands (Van der Oost, R., Goksøyr, A., Celander, M., Heida, H., & Vermeulen, N. P. E. 1996. Aquatic Toxicology, 36, 189-222), the Thames is suggested to be moderately impacted by polycyclic aromatic hydrocarbons and related contaminants. 17-beta-Estradiol treatment produced the appearance of a plasma protein of 211 Kd app. mol. wt. (recognised by antibodies to vitellogenin of Morone saxatilis), but putative vitellogenin could not be detected in A. anguilla from selected sites in the Thames Estuary.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Anguilla
- blood
- metabolism
- Animals
- Biological Markers
- Cytochrome P-450 CYP1A1
- metabolism
- Environmental Monitoring
- Estradiol
- toxicity
- Great Britain
- Liver
- drug effects
- enzymology
- Vitellogenins
- metabolism
- Water Pollutants
- Chemical
- toxicity
- beta-Naphthoflavone
- toxicity
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Livingstone, D R
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Mitchelmore, C L
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Peters, L D
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O'Hara, S C
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Shaw, J P
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Chesman, B S
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show more...
-
Doyotte, A
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McEvoy, J
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Ronisz, Dan
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Larsson, D. G. J ...
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Förlin, Lars, 19 ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Marine environme ...
- By the university
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University of Gothenburg