WFRF:(Peters R)
Sökning: WFRF:(Peters R) > (2000-2004) > Development of hepa...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03905naa a2200637 4500 | |
| 001 | oai:gup.ub.gu.se/187397 | |
| 003 | SwePub | |
| 008 | 240910s2002 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/1873972 URI |
| 024 | 7 | a https://doi.org/10.1016/S0141-1136(00)00060-X2 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Livingstone, D R4 aut |
| 245 | 1 0 | a Development of hepatic CYP1A and blood vitellogenin in eel (Anguilla anguilla) for use as biomarkers in the Thames Estuary, UK. |
| 264 | 1 | c 2002 |
| 520 | a The potential of eel (Anguilla anguilla) as a monitoring species for the Thames Estuary, UK, was examined. Hepatic cytochrome P4501A [7-ethoxyresorufin O-deethylase (EROD) activity] and blood vitellogenin (Western analysis) were investigated as biomarkers of exposure to, respectively, organic contaminants and to contaminants showing estrogenic activity. Hepatic microsomal EROD activities in A. anguilla from seven sites in the Thames Estuary in May 1998 varied three-fold (111 +/- 24 to 355 +/- 42 pmol min-1 mg protein-1) (mean +/- S.E.M.) and showed correlation with salinity; however, the latter relationship was not maintained at other times of the year. The range of EROD activities was two- to eight-fold higher than the 37 +/- 8 pmol min-1 mg-1 for A. anguilla from the relatively clean Tamar Estuary. beta-Naphthoflavone treatment (5 mg kg-1 wet wt.; 2 days) of Thames A. anguilla produced a two-fold increase in hepatic microsomal EROD activity. Comparing the Thames EROD data with those for A. anguilla from well-characterised contaminated sites in the Netherlands (Van der Oost, R., Goksøyr, A., Celander, M., Heida, H., & Vermeulen, N. P. E. 1996. Aquatic Toxicology, 36, 189-222), the Thames is suggested to be moderately impacted by polycyclic aromatic hydrocarbons and related contaminants. 17-beta-Estradiol treatment produced the appearance of a plasma protein of 211 Kd app. mol. wt. (recognised by antibodies to vitellogenin of Morone saxatilis), but putative vitellogenin could not be detected in A. anguilla from selected sites in the Thames Estuary. | |
| 650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
| 653 | a Anguilla | |
| 653 | a blood | |
| 653 | a metabolism | |
| 653 | a Animals | |
| 653 | a Biological Markers | |
| 653 | a Cytochrome P-450 CYP1A1 | |
| 653 | a metabolism | |
| 653 | a Environmental Monitoring | |
| 653 | a Estradiol | |
| 653 | a toxicity | |
| 653 | a Great Britain | |
| 653 | a Liver | |
| 653 | a drug effects | |
| 653 | a enzymology | |
| 653 | a Vitellogenins | |
| 653 | a metabolism | |
| 653 | a Water Pollutants | |
| 653 | a Chemical | |
| 653 | a toxicity | |
| 653 | a beta-Naphthoflavone | |
| 653 | a toxicity | |
| 700 | 1 | a Mitchelmore, C L4 aut |
| 700 | 1 | a Peters, L D4 aut |
| 700 | 1 | a O'Hara, S C4 aut |
| 700 | 1 | a Shaw, J P4 aut |
| 700 | 1 | a Chesman, B S4 aut |
| 700 | 1 | a Doyotte, A4 aut |
| 700 | 1 | a McEvoy, J4 aut |
| 700 | 1 | a Ronisz, Danu Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology4 aut |
| 700 | 1 | a Larsson, D. G. Joakim,d 1969u Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology4 aut0 (Swepub:gu)xlarjo |
| 700 | 1 | a Förlin, Lars,d 1950u Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology4 aut0 (Swepub:gu)xfolar |
| 710 | 2 | a Göteborgs universitetb Zoologiska institutionen4 org |
| 773 | 0 | t Marine environmental researchg 50:1-5, s. 367-71q 50:1-5<367-71x 0141-1136 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/187397 |
| 856 | 4 8 | u https://doi.org/10.1016/S0141-1136(00)00060-X |
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