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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
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001oai:DiVA.org:uu-460212
003SwePub
008220112s2021 | |||||||||||000 ||eng|
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0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4602122 URI
0247 a https://doi.org/10.1038/s41598-021-01177-72 DOI
0247 a https://lup.lub.lu.se/record/00dc749d-6edf-4279-a24e-2b87fe7289ab2 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1481369102 URI
040 a (SwePub)uud (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Cediel Ulloa, Andreau Uppsala University,Karolinska Institute,Uppsala universitet,Miljötoxikologi,Karolinska Inst, Inst Environm Med, Box 210, S-17177 Stockholm, Sweden.4 aut0 (Swepub:uu)andce270
2451 0a Toxicity of stainless and mild steel particles generated from gas-metal arc welding in primary human small airway epithelial cells
264 c 2021-11-08
264 1b Springer Nature,c 2021
338 a electronic2 rdacarrier
520 a Welding fumes induce lung toxicity and are carcinogenic to humans but the molecular mechanisms have yet to be clarified. The aim of this study was to evaluate the toxicity of stainless and mild steel particles generated via gas-metal arc welding using primary human small airway epithelial cells (hSAEC) and ToxTracker reporter murine stem cells, which track activation of six cancer-related pathways. Metal content (Fe, Mn, Ni, Cr) of the particles was relatively homogenous across particle size. The particles were not cytotoxic in reporter stem cells but stainless steel particles activated the Nrf2-dependent oxidative stress pathway. In hSAEC, both particle types induced time- and dose-dependent cytotoxicity, and stainless steel particles also increased generation of reactive oxygen species. The cellular metal content was higher for hSAEC compared to the reporter stem cells exposed to the same nominal dose. This was, in part, related to differences in particle agglomeration/sedimentation in the different cell media. Overall, our study showed differences in cytotoxicity and activation of cancer-related pathways between stainless and mild steel welding particles. Moreover, our data emphasizes the need for careful assessment of the cellular dose when comparing studies using different in vitro models.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
7001 a Isaxon, Christinau Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)desi-cti
7001 a Eriksson, Axelu Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)desi-ale
7001 a Primetzhofer, Danielu Uppsala University,Uppsala universitet,Tillämpad kärnfysik,Tandemlaboratoriet4 aut0 (Swepub:uu)danpr521
7001 a Sortica, Mauricio A.u Uppsala University,Uppsala universitet,Tillämpad kärnfysik,Tandemlaboratoriet4 aut0 (Swepub:uu)mauso471
7001 a Haag, Larsu Karolinska Institutet,Karolinska Institute4 aut
7001 a Derr, Remcou Toxys, Leiden, Netherlands.,Toxys B.V.4 aut
7001 a Hendriks, Gielu Toxys, Leiden, Netherlands.,Toxys B.V.4 aut
7001 a Löndahl, Jakobu Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)desi-jlo
7001 a Gudmundsson, Andersu Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Other operations, LTH,Faculty of Engineering, LTH,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH4 aut0 (Swepub:lu)amt-agu
7001 a Broberg, Karinu Karolinska Institutet,Karolinska Institute4 aut
7001 a Gliga, Anda R.u Karolinska Institutet,Karolinska Institute4 aut0 (Swepub:lu)an3300gl
7102 a Uppsala universitetb Miljötoxikologi4 org
7730 t Scientific Reportsd : Springer Natureg 11:1q 11:1x 2045-2322
8564 u https://doi.org/10.1038/s41598-021-01177-7y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1627013/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.nature.com/articles/s41598-021-01177-7.pdf
8564 u http://dx.doi.org/10.1038/s41598-021-01177-7x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-460212
8564 8u https://doi.org/10.1038/s41598-021-01177-7
8564 8u https://lup.lub.lu.se/record/00dc749d-6edf-4279-a24e-2b87fe7289ab
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:148136910

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