WFRF:(Porkka K.)
Sökning: WFRF:(Porkka K.) > (2010-2014) > Impact of malignant...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06371naa a2200829 4500 | |
| 001 | oai:DiVA.org:umu-79430 | |
| 003 | SwePub | |
| 008 | 130819s2013 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:kth-205248 | |
| 009 | oai:prod.swepub.kib.ki.se:127092517 | |
| 009 | oai:DiVA.org:uu-206461 | |
| 009 | oai:lup.lub.lu.se:2e50fd0b-e81b-4cf1-bc39-6d9a0c41214b | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-794302 URI |
| 024 | 7 | a https://doi.org/10.1038/leu.2013.192 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2052482 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1270925172 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2064612 URI |
| 024 | 7 | a https://lup.lub.lu.se/record/39740582 URI |
| 040 | a (SwePub)umud (SwePub)kthd (SwePub)kid (SwePub)uud (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Mustjoki, Su University of Helsinki, Finland4 aut |
| 245 | 1 0 | a Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients |
| 264 | c 2013-01-18 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2013 |
| 338 | a print2 rdacarrier | |
| 500 | a QC 20170419 | |
| 520 | a Chronic myeloid leukemia (CML) stem cells appear resistant to tyrosine kinase inhibitors (TKIs) in vitro, but their impact and drug sensitivity in vivo has not been systematically assessed. We prospectively analyzed the proportion of Philadelphia chromosome-positive leukemic stem cells (LSCs, Ph+CD34+CD38=) and progenitor cells (LPCs, Ph+CD34+CD38+) from 46 newly diagnosed CML patients both at the diagnosis and during imatinib or dasatinib therapy (ClinicalTrials.gov NCT00852566). At diagnosis, the proportion of LSCs varied markedly (1-100%) between individual patients with a significantly lower median value as compared with LPCs (79% vs 96%, respectively, P = 0.0001). The LSC burden correlated with leukocyte count, spleen size, hemoglobin and blast percentage. A low initial LSC percentage was associated with less therapy-related hematological toxicity and superior cytogenetic and molecular responses. After initiation of TKI therapy, the LPCs and LSCs rapidly decreased in both therapy groups, but at 3 months time point the median LPC level was significantly lower in dasatinib group compared with imatinib patients (0.05% vs 0.68%, P = 0.032). These data detail for the first time the prognostic significance of the LSC burden at diagnosis and show that in contrast to in vitro data, TKI therapy rapidly eradicates the majority of LSCs in patients. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a CML | |
| 653 | a leukemia stem cell | |
| 653 | a tyrosine kinase inhibitor | |
| 653 | a progenitor | |
| 653 | a CML | |
| 653 | a leukemia stem cell | |
| 653 | a tyrosine kinase inhibitor | |
| 653 | a progenitor | |
| 700 | 1 | a Richter, Johanu Lund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-jri |
| 700 | 1 | a Barbany, Gu Karolinska Institutet4 aut |
| 700 | 1 | a Ehrencrona, Hansu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-hen |
| 700 | 1 | a Fioretos, Thoasu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-tfi |
| 700 | 1 | a Gedde-Dahl, Tu Oslo university hospital, Norway4 aut |
| 700 | 1 | a Gjertsen, BT4 aut |
| 700 | 1 | a Hovland, Ru Haukeland university hospital, Norway4 aut |
| 700 | 1 | a Hernesniemi, Su University of Helsinki, Finland4 aut |
| 700 | 1 | a Josefsen, Du The noewegian radium hospital, Norway4 aut |
| 700 | 1 | a Koskenvesa, Pu University of Helsinki, Finland,Norwegian University of Science and Technology, Norway4 aut |
| 700 | 1 | a Dybedal, Iu Oslo university hospital, Norway4 aut |
| 700 | 1 | a Markevärn, Beritu Umeå universitet,Medicinska fakulteten,Umeå university hospital, Sweden4 aut0 (Swepub:umu)bema0022 |
| 700 | 1 | a Olofsson, Tobiasu Lund University,Lunds universitet,Institutionen för laboratoriemedicin,Medicinska fakulteten,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)livs-tol |
| 700 | 1 | a Olsson-Strömberg, Ullau Uppsala universitet,Hematologi4 aut0 (Swepub:uu)ulols170 |
| 700 | 1 | a Rapakko, K.u Oulo university hospital, Sweden4 aut |
| 700 | 1 | a Thunberg, Sarah,d 1976-u Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:kth)u1rw1xrj |
| 700 | 1 | a Stenke, L.u Karolinska Institutet4 aut |
| 700 | 1 | a Simonsson, Bengtu Uppsala universitet,Hematologi4 aut0 (Swepub:uu)bengtss |
| 700 | 1 | a Porkka, K.4 aut |
| 700 | 1 | a Hjorth-Hansen, H.u Norwegian University of Science and Technology, Norway4 aut |
| 710 | 2 | a University of Helsinki, Finlandb Avdelningen för molekylärmedicin och genterapi4 org |
| 773 | 0 | t Leukemiad : Springer Science and Business Media LLCg 27:7, s. 1520-1526q 27:7<1520-1526x 0887-6924x 1476-5551 |
| 856 | 4 | u https://www.nature.com/articles/leu201319.pdf |
| 856 | 4 | u http://dx.doi.org/10.1038/leu.2013.19y FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-79430 |
| 856 | 4 8 | u https://doi.org/10.1038/leu.2013.19 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-205248 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:127092517 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206461 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/3974058 |
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