WFRF:(Rautelin Hilpi)
Sökning: WFRF:(Rautelin Hilpi) > Susceptibility to C...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05000naa a2200409 4500 | |
| 001 | oai:DiVA.org:uu-240157 | |
| 003 | SwePub | |
| 008 | 150105s2014 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:130209806 | |
| 009 | oai:slubar.slu.se:64162 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2401572 URI |
| 024 | 7 | a https://doi.org/10.1128/mBio.01212-142 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1302098062 URI |
| 024 | 7 | a https://res.slu.se/id/publ/641622 URI |
| 040 | a (SwePub)uud (SwePub)kid (SwePub)slu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Dicksved, Johanu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinska vetenskaper,Institutionen för husdjurens utfodring och vård (HUV),Department of Animal Nutrition and Management,Uppsala University4 aut0 (Swepub:slu)47518 |
| 245 | 1 0 | a Susceptibility to Campylobacter Infection Is Associated with the Species Composition of the Human Fecal Microbiota |
| 264 | 1 | c 2014 |
| 338 | a electronic2 rdacarrier | |
| 520 | a The gut microbiota is essential for human health, but very little is known about how the composition of this ecosystem can influence and respond to bacterial infections. Here we address this by prospectively studying the gut microbiota composition before, during, and after natural Campylobacter infection in exposed poultry abattoir workers. The gut microbiota composition was analyzed with 16S amplicon sequencing of fecal samples from poultry abattoir workers during the peak season of Campylobacter infection in Sweden. The gut microbiota compositions were compared between individuals who became culture positive for Campylobacter and those who remained negative. Individuals who became Campylobacter positive had a significantly higher abundance of Bacteroides (P = 0.007) and Escherichia (P = 0.002) species than those who remained culture negative. Furthermore, this group had a significantly higher abundance of Phascolarctobacterium (P = 0.017) and Streptococcus (P = 0.034) sequences than the Campylobacter-negative group, which had an overrepresentation of Clostridiales (P = 0.017), unclassified Lachnospiraceae (P = 0.008), and Anaerovorax (P = 0.015) sequences. Intraindividual comparisons of the fecal microbiota compositions yielded small differences over time in Campylobacter-negative participants, but significant long-term changes were found in the Campylobacter-positive group (P < 0.005). The results suggest that the abundance of specific genera in the microbiota reduces resistance to Campylobacter colonization in humans and that Campylobacter infection can have long-term effects on the composition of the human fecal microbiota. IMPORTANCE Studies using mouse models have made important contributions to our understanding of the role of the gut microbiota in resistance to bacterial enteropathogen colonization. The relative abundances of Escherichia coli and Bacteroides species have been pointed out as important determinants of susceptibility to Gram-negative pathogens in general and Campylobacter infection in particular. In this study, we assessed the role of the human gut microbiota in resistance to Campylobacter colonization by studying abattoir workers that are heavily exposed to these bacteria. Individuals with a certain composition of the gut microbiota became culture positive for Campylobacter. As their microbiotas were characterized by high abundances of Bacteroides spp. and E. coli, well in line with the findings with mouse models, these bacterial species likely play an important role in colonization resistance also in humans. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
| 700 | 1 | a Ellström, Patriku Uppsala universitet,Klinisk mikrobiologi och infektionsmedicin,Institutionen för medicinsk biokemi och mikrobiologi4 aut0 (Swepub:uu)patel687 |
| 700 | 1 | a Engstrand, Larsu Karolinska Institutet4 aut |
| 700 | 1 | a Rautelin, Hilpiu Uppsala universitet,Klinisk mikrobiologi och infektionsmedicin4 aut0 (Swepub:uu)hilra999 |
| 710 | 2 | a Uppsala universitetb Institutionen för medicinska vetenskaper4 org |
| 710 | 2 | a Sveriges lantbruksuniversitet |
| 773 | 0 | t mBiog 5:5, s. e01212-14-q 5:5<e01212-14-x 2161-2129x 2150-7511 |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:776594/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-240157 |
| 856 | 4 8 | u https://doi.org/10.1128/mBio.01212-14 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130209806 |
| 856 | 4 8 | u https://res.slu.se/id/publ/64162 |
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