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CSF T-Tau/Aβ42 pred...
CSF T-Tau/Aβ42 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease.
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Bendlin, Barbara B (författare)
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Carlsson, Cynthia M (författare)
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Johnson, Sterling C (författare)
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Willette, Auriel A (författare)
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Okonkwo, Ozioma C (författare)
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Sodhi, Aparna (författare)
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Ries, Michele L (författare)
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Birdsill, Alex C (författare)
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Alexander, Andrew L (författare)
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Rowley, Howard A (författare)
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Puglielli, Luigi (författare)
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Asthana, Sanjay (författare)
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Sager, Mark A (författare)
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(creator_code:org_t)
- 2012-06-06
- 2012
- Engelska.
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Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 7:6
- Relaterad länk:
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https://journals.plo...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cerebrospinal fluid (CSF) biomarkers T-Tau and Aβ(42) are linked with Alzheimer's disease (AD), yet little is known about the relationship between CSF biomarkers and structural brain alteration in healthy adults. In this study we examined the extent to which AD biomarkers measured in CSF predict brain microstructure indexed by diffusion tensor imaging (DTI) and volume indexed by T1-weighted imaging. Forty-three middle-aged adults with parental family history of AD received baseline lumbar puncture and MRI approximately 3.5 years later. Voxel-wise image analysis methods were used to test whether baseline CSF Aβ(42), total tau (T-Tau), phosphorylated tau (P-Tau) and neurofilament light protein predicted brain microstructure as indexed by DTI and gray matter volume indexed by T1-weighted imaging. T-Tau and T-Tau/Aβ(42) were widely correlated with indices of brain microstructure (mean, axial, and radial diffusivity), notably in white matter regions adjacent to gray matter structures affected in the earliest stages of AD. None of the CSF biomarkers were related to gray matter volume. Elevated P-Tau and P-Tau/Aβ(42) levels were associated with lower recognition performance on the Rey Auditory Verbal Learning Test. Overall, the results suggest that CSF biomarkers are related to brain microstructure in healthy adults with elevated risk of developing AD. Furthermore, the results clearly suggest that early pathological changes in AD can be detected with DTI and occur not only in cortex, but also in white matter.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Adult
- Alzheimer Disease
- diagnosis
- genetics
- pathology
- Amyloid beta-Peptides
- cerebrospinal fluid
- Analysis of Variance
- Biological Markers
- cerebrospinal fluid
- Diffusion Tensor Imaging
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Myelin Sheath
- pathology
- Neuropsychological Tests
- Peptide Fragments
- cerebrospinal fluid
- Phosphorylation
- Recognition (Psychology)
- physiology
- Wisconsin
- tau Proteins
- metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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PloS one
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Till lärosätets databas
- Av författaren/redakt...
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Bendlin, Barbara ...
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Carlsson, Cynthi ...
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Johnson, Sterlin ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Willette, Auriel ...
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visa fler...
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Okonkwo, Ozioma ...
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Sodhi, Aparna
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Ries, Michele L
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Birdsill, Alex C
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Alexander, Andre ...
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Rowley, Howard A
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Puglielli, Luigi
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Asthana, Sanjay
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Sager, Mark A
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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PloS one
- Av lärosätet
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Göteborgs universitet