SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Särndahl Eva)
 

Sökning: WFRF:(Särndahl Eva) > Immunotoxic, genoto...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006492naa a2200493 4500
001oai:DiVA.org:oru-110605
003SwePub
008240109s2024 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1106052 URI
0247 a https://doi.org/10.1016/j.envint.2023.1084122 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Alijagic, Andi,d 1992-u Örebro universitet,Institutionen för naturvetenskap och teknik,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Man-Technology-Environment Research Center (MTM)4 aut0 (Swepub:oru)aiac
2451 0a Immunotoxic, genotoxic, and endocrine disrupting impacts of polyamide microplastic particles and chemicals
264 1b Elsevier,c 2024
338 a print2 rdacarrier
520 a Due to their exceptional properties and cost effectiveness, polyamides or nylons have emerged as widely used materials, revolutionizing diverse industries, including industrial 3D printing or additive manufacturing (AM). Powder-based AM technologies employ tonnes of polyamide microplastics to produce complex components every year. However, the lack of comprehensive toxicity assessment of particulate polyamides and polyamide-associated chemicals, especially in the light of the global microplastics crisis, calls for urgent action. This study investigated the physicochemical properties of polyamide-12 microplastics used in AM, and assessed a number of toxicity endpoints focusing on inflammation, immunometabolism, genotoxicity, aryl hydrocarbon receptor (AhR) activation, endocrine disruption, and cell morphology. Specifically, microplastics examination by means of field emission scanning electron microscopy revealed that work flow reuse of material created a fraction of smaller particles with an average size of 1-5 µm, a size range readily available for uptake by human cells. Moreover, chemical analysis by means of gas chromatography high-resolution mass spectrometry detected several polyamide-associated chemicals including starting material, plasticizer, thermal stabilizer/antioxidant, and migrating slip additive. Even if polyamide particles and chemicals did not induce an acute inflammatory response, repeated and prolonged exposure of human primary macrophages disclosed a steady increase in the levels of proinflammatory chemokine Interleukin-8 (IL-8/CXCL-8). Moreover, targeted metabolomics disclosed that polyamide particles modulated the kynurenine pathway and some of its key metabolites. The p53-responsive luciferase reporter gene assay showed that particles per se were able to activate p53, being indicative of a genotoxic stress. Polyamide-associated chemicals triggered moderate activation of AhR and elicited anti-androgenic activity. Finally, a high-throughput and non-targeted morphological profiling by Cell Painting assay outlined major sites of bioactivity of polyamide-associated chemicals and indicated putative mechanisms of toxicity in the cells. These findings reveal that the increasing use of polyamide microplastics may pose a potential health risk for the exposed individuals, and it merits more attention.
650 7a NATURVETENSKAPx Geovetenskap och miljövetenskapx Miljövetenskap0 (SwePub)105022 hsv//swe
650 7a NATURAL SCIENCESx Earth and Related Environmental Sciencesx Environmental Sciences0 (SwePub)105022 hsv//eng
653 a Additive manufacturing
653 a GC-HRMS
653 a High-throughput morphological profiling
653 a Metabolomics
653 a Nylon
653 a Plastic additives
7001 a Kotlyar, Oleksandr,d 1982-u Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Center (MTM); Centre for Applied Autonomous Sensor Systems (AASS); Mobile Robotics and Olfaction Lab (MRO)4 aut0 (Swepub:oru)okr
7001 a Larsson, Maria,d 1975-u Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Center (MTM)4 aut0 (Swepub:oru)miln
7001 a Salihovic, Samira,c Associate Senior Lecturer,d 1985-u Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)sasc
7001 a Hedbrant, Alexander,c Ph.D,d 1987-u Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)arht
7001 a Eriksson, Ulrika,d 1972-u Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Center (MTM)4 aut0 (Swepub:oru)uaen
7001 a Karlsson, Patrik,d 1973-u Örebro universitet,Institutionen för naturvetenskap och teknik4 aut0 (Swepub:oru)pkkn
7001 a Persson, Alexander,d 1978-u Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)axpn
7001 a Scherbak, Nikolai,d 1967-u Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Center (MTM)4 aut0 (Swepub:oru)nsk
7001 a Färnlund, Kimu AMEXCI AB, Karlskoga, Sweden4 aut
7001 a Engwall, Magnus,d 1965-u Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Center (MTM)4 aut0 (Swepub:oru)mel
7001 a Särndahl, Eva,d 1963-u Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)easl
7102 a Örebro universitetb Institutionen för naturvetenskap och teknik4 org
7730 t Environment Internationald : Elsevierg 183q 183x 0160-4120x 1873-6750
8564 u https://doi.org/10.1016/j.envint.2023.108412y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-110605
8564 8u https://doi.org/10.1016/j.envint.2023.108412

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy