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WFRF:(Sörlie Therese)
 

Sökning: WFRF:(Sörlie Therese) > Molecular Features ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005304naa a2200421 4500
001oai:DiVA.org:uu-303121
003SwePub
008160915s2016 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3031212 URI
0247 a https://doi.org/10.1016/j.celrep.2016.06.0512 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lesurf, Robertu McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada.;McGill Univ, McGill Ctr Bioinformat, Montreal, PQ H3G 1Y6, Canada.;McGill Univ, Rosalind & Morris Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada.4 aut
2451 0a Molecular Features of Subtype-Specific Progression from Ductal Carcinoma In Situ to Invasive Breast Cancer
264 1b Elsevier BV,c 2016
338 a electronic2 rdacarrier
520 a Breast cancer consists of at least five main molecular "intrinsic'' subtypes that are reflected in both pre-invasive and invasive disease. Although previous studies have suggested that many of the molecular features of invasive breast cancer are established early, it is unclear what mechanisms drive progression and whether the mechanisms of progression are dependent or independent of subtype. We have generated mRNA, miRNA, and DNA copy-number profiles from a total of 59 in situ lesions and 85 invasive tumors in order to comprehensively identify those genes, signaling pathways, processes, and cell types that are involved in breast cancer progression. Our work provides evidence that there are molecular features associated with disease progression that are unique to the intrinsic subtypes. We additionally establish subtype-specific signatures that are able to identify a small proportion of pre-invasive tumors with expression profiles that resemble invasive carcinoma, indicating a higher likelihood of future disease progression.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
7001 a Aure, Miriam Ragleu Norwegian Radium Hosp, Oslo Univ Hosp, Inst Canc Res, N-0424 Oslo, Norway.;Norwegian Radium Hosp, Oslo Univ Hosp, Dept Canc Genet, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, KG Jebsen Ctr Breast Canc Res, N-0318 Oslo, Norway.4 aut
7001 a Mörk, Hanne Habergu Norwegian Radium Hosp, Oslo Univ Hosp, Inst Canc Res, N-0424 Oslo, Norway.;Norwegian Radium Hosp, Oslo Univ Hosp, Dept Canc Genet, N-0424 Oslo, Norway.4 aut
7001 a Vitelli, Valeriau Univ Oslo, Oslo Ctr Biostat & Epidemiol, N-0317 Oslo, Norway.;Univ Oslo, Dept Biostat, N-0317 Oslo, Norway. St Olavs Univ Hosp, Dept Oncol, N-7006 Trondheim, Norway.4 aut
7001 a Lundgren, Steinaru Department of Oncology, St. Olav’s University Hospital, 7006 Trondheim, Norway.; Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway4 aut
7001 a Börresen-Dale, Anne-Liseu Norwegian Radium Hosp, Oslo Univ Hosp, Inst Canc Res, N-0424 Oslo, Norway.;Norwegian Radium Hosp, Oslo Univ Hosp, Dept Canc Genet, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, KG Jebsen Ctr Breast Canc Res, N-0318 Oslo, Norway.4 aut
7001 a Kristensen, Vesselau Norwegian Radium Hosp, Oslo Univ Hosp, Inst Canc Res, N-0424 Oslo, Norway.;Norwegian Radium Hosp, Oslo Univ Hosp, Dept Canc Genet, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, KG Jebsen Ctr Breast Canc Res, N-0318 Oslo, Norway.;Akershus Univ Hosp, Dept Clin Mol Biol & Lab Sci EpiGen, Div Med, N-1478 Lorenskog, Norway.4 aut
7001 a Wämberg, Fredriku Uppsala universitet,Endokrinkirurgi4 aut0 (Swepub:uu)fredwarn
7001 a Hallett, Michaelu McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada.;McGill Univ, McGill Ctr Bioinformat, Montreal, PQ H3G 1Y6, Canada.;McGill Univ, Sch Comp Sci, Montreal, PQ H3A 0E9, Canada.4 aut
7001 a Sörlie, Thereseu Norwegian Radium Hosp, Oslo Univ Hosp, Inst Canc Res, N-0424 Oslo, Norway.;Norwegian Radium Hosp, Oslo Univ Hosp, Dept Canc Genet, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, KG Jebsen Ctr Breast Canc Res, N-0318 Oslo, Norway.4 aut
7102 a McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada.;McGill Univ, McGill Ctr Bioinformat, Montreal, PQ H3G 1Y6, Canada.;McGill Univ, Rosalind & Morris Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada.b Norwegian Radium Hosp, Oslo Univ Hosp, Inst Canc Res, N-0424 Oslo, Norway.;Norwegian Radium Hosp, Oslo Univ Hosp, Dept Canc Genet, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, KG Jebsen Ctr Breast Canc Res, N-0318 Oslo, Norway.4 org
7730 t Cell Reportsd : Elsevier BVg 16:4, s. 1166-1179q 16:4<1166-1179x 2211-1247
8564 u https://doi.org/10.1016/j.celrep.2016.06.051y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:971239/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://www.cell.com/article/S2211124716308051/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-303121
8564 8u https://doi.org/10.1016/j.celrep.2016.06.051

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