Experience with solid organ transplantation in patients with previous immunotherapy treatment is still limited but this is changing: The survey-based view of the global transplant society

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Experience with solid organ transplantation in patients with previous immunotherapy treatment is still limited but this is changing : The survey-based view of the global transplant society

Ivanics, Tommy (author): Uppsala universitet,Gastrointestinalkirurgi,Univ Hlth Network Toronto, Multiorgan Transplant Program, Toronto, ON, Canada.;Henry Ford Hosp, Dept Surg, Detroit, MI USA.

Claasen, M. paw (author): Univ Hlth Network Toronto, Multiorgan Transplant Program, Toronto, ON, Canada.;Univ Med Ctr Rotterdam, Erasmus MC Transplant Inst, Dept Surg, Div HPB & Transplant Surg, Rotterdam, Netherlands.

Al-Adra, D. (author): Univ Wisconsin Sch Med & Publ Hlth, Div Transplantat, Madison, WI USA.

Sapisochin, G. (author): Univ Hlth Network Toronto, Multiorgan Transplant Program, Toronto, ON, Canada.;Univ Hlth Network, Div Gen Surg, Toronto, ON, Canada.;Univ Toronto Staff Surg, HBP & Multi Organ Transplant Program Div Gen Surg, Univ Hlth Network 585 Univ Ave,11PMB184, Toronto, ON M5G 2N2, Canada.

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Elsevier, 2022
2022
English.
In: Transplant Immunology. - : Elsevier. - 0966-3274 .- 1878-5492. ; 73

Related links:: https://doi.org/10.1...; show more...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: The use of immunotherapy for cancer is increasing and is expected to continue growing. The outcomes after solid organ transplantation(SOT) in patients who received immunotherapy before SOT remain unclear. We evaluated the global transplant surgery community's attitude towards and experience with patients who received immunotherapy for malignancy before SOT. Methods: An online-based survey was sent to North American transplant program directors in December-2020 and members of the International Liver Transplant Society in November-2021 evaluating experiences with and attitudes towards SOT in recipients with previous immunotherapy for cancer. Results: A total of 119 respondents completed the survey(119/175;completion rate:68%), representing centers from North America, South America, Europe, Asia, and Australia. Seventy-one(62%) respondents would consider SOT in patients with a previous history of immunotherapy for cancer, whereas thirty-nine(34%) were aware of such immunotherapy-treated recipients being transplanted, with an increasing trend over the last few years(2016 [n = 1]-2020[n = 14]). Institutional clinical management policies in this setting were lacking in most centers(n = 85[75%]). Conclusions: The international transplant community is receptive to transplanting transplant candidates previously treated with immunotherapy for cancer, although experience is still limited. In this context, more centers have started to offer SOT to patients with a history of immunotherapy for cancer in recent years. However, support from clear and robust institutional policies in this endeavor is scant. Therefore, there is a high need for consensus guidelines to inform future clinical management, especially as immunotherapy for cancer is likely to continue to increase in the coming years.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Keyword

Immunotherapy
Solid organ transplantation
Global
Survey

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By the author/editor: Ivanics, Tommy; Claasen, M. paw; Al-Adra, D.; Sapisochin, G.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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