Intrathecally applied morphine inhibits nociceptive C fiber input to the primary somatosensory cortex (SI) of the rat

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Fältnamn	Indikatorer	Metadata
000		02788naa a2200385 4500
001		oai:lup.lub.lu.se:9bf6a87d-7c23-4518-9fe0-a6d892684f93
003		SwePub
008		190625s1998 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/9bf6a87d-7c23-4518-9fe0-a6d892684f932 URI
024	7	a https://doi.org/10.1016/S0304-3959(98)00115-82 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Kalliomäki, Jarkkou Skåne University Hospital4 aut
245	1 0	a Intrathecally applied morphine inhibits nociceptive C fiber input to the primary somatosensory cortex (SI) of the rat
264	1	c 1998
520		a Nociceptive C fiber input to SI in the halothane-nitrous oxide anesthetized rat was assessed by recording cortical field potentials evoked by noxious thermal cutaneous stimulation with CO2-laser pulses. Morphine topically applied onto the lumbar spinal cord produced a dose-dependent inhibition of nociceptive C fiber input from the hind paw to the contralateral SI. The inhibitory effect of morphine was reversed by naloxone. Potentials evoked by CO2-laser stimulation of the forepaw were unaffected by morphine applied on the lumbar cord, indicating that the effect of morphine was exerted at the segmental level. It is concluded that input from nociceptive C fibers to SI is relayed in the spinal cord and can be inhibited by spinal opioid receptor activation. The present method offers an interesting model of ascending nociceptive transmission to the cerebral cortex. Copyright (C) 1998 International Association for the Study of Pain. Published by Elsevier Science B.V.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653		a Analgesia
653		a Cerebral cortex
653		a Evoked potential
653		a Opioids
653		a Pain
653		a Somatosensory pathways
700	1	a Luo, Xiao Lingu Skåne University Hospital4 aut
700	1	a Yu, Yong Beiu Skåne University Hospital4 aut
700	1	a Schouenborg, Jensu Lund University,Lunds universitet,Neuronano Research Center (NRC),Forskargrupper vid Lunds universitet,Lund University Research Groups4 aut0 (Swepub:lu)mphy-jsc
710	2	a Skåne University Hospitalb Neuronano Research Center (NRC)4 org
773	0	t Paing 77:3, s. 323-329q 77:3<323-329x 0304-3959
856	4	u http://dx.doi.org/10.1016/S0304-3959(98)00115-8y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/9bf6a87d-7c23-4518-9fe0-a6d892684f93
856	4 8	u https://doi.org/10.1016/S0304-3959(98)00115-8

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