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Reproducible grey m...
Reproducible grey matter patterns index a multivariate, global alteration of brain structure in schizophrenia and bipolar disorder
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- Schwarz, E (author)
- Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany.,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
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- Doan, NT (author)
- Norwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
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- Pergola, G (author)
- Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.,Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.
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show more...
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- Westlye, LT (author)
- Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.;Univ Oslo, Dept Psychol, Oslo, Norway.
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- Kaufmann, T (author)
- Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.
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- Wolfers, T (author)
- Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Donders Ctr Cognit Neuroimaging, Nijmegen, Netherlands.
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- Brecheisen, R (author)
- Maastricht Univ, Med Ctr, Maastricht, Netherlands.
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- Quarto, T (author)
- Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.;Univ Helsinki, Dept Psychol & Logoped, Cognit Brain Res Unit, Fac Med, Helsinki, Finland.
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- Ing, AJ (author)
- Kings Coll London, Ctr Populat Neurosci & Stratified Med PONS, London, England.;Kings Coll London, MRC SGDP Ctr, Inst Psychiat Psychol & Neurosci, London, England.,Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.;Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.;Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.
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- Di Carlo, P (author)
- Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.
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Gurholt, TP (author)
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- Harms, RL (author)
- Brain Innovat BV, Maastricht, Netherlands.,Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland.
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- Noirhomme, Q (author)
- Brain Innovat BV, Maastricht, Netherlands.
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- Moberget, T (author)
- Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.,Univ Southern Calif, Stevens Inst Neuroimaging & Informat, Imaging Genet Ctr, Los Angeles, CA USA.
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- Agartz, I (author)
- Karolinska Institutet,Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.;Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.;Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.
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- Andreassen, OA (author)
- Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.
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- Bellani, M (author)
- Azienda Osped Univ Integrata Verona, Sect Psychiat, Verona, VR, Italy.;Univ Verona, Dept Neurosci Biomed & Movements Sci, Verona, VR, Italy.
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- Bertolino, A (author)
- Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.;Azienda Osped Univ Consorziale Policlin Bari, Policlin Bari, Inst Psichiatry, Bari, BA, Italy.
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- Blasi, G (author)
- Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.;Azienda Osped Univ Consorziale Policlin, Bari, Italy.
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- Brambilla, P (author)
- Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Neurosci & Mental Hlth, Milan, Italy.
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- Buitelaar, JK (author)
- Radboudumc, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Karakter Child & Adolescent Psychiat Univ Ctr, Nijmegen, Netherlands.
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- Cervenka, Simon (author)
- Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.
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- Flyckt, L (author)
- Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.
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- Frangou, S (author)
- Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
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- Franke, B (author)
- Radboudumc, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Dept Psychiat, Med Ctr, Nijmegen, Netherlands.
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- Hall, J (author)
- Cardiff Univ, Neurosci & Mental Hlth Res Inst, Maindy Rd, Cardiff CF24 4HQ, S Glam, Wales.
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- Heslenfeld, DJ (author)
- Vrije Univ Amsterdam, Dept Cognit Psychol, Amsterdam, Netherlands.
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- Kirsch, P (author)
- Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Clin Psychol, Heidelberg, Germany.;Bernstein Ctr Computat Neurosci Heidelberg Mannhe, Mannheim, Germany.
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- McIntosh, AM (author)
- Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland.;Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, George Sq, Edinburgh EH8 9JZ, Midlothian, Scotland.,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
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- Nothen, MM (author)
- Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany.;Univ Hosp Bonn, Bonn, Germany.;Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.
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- Papassotiropoulos, A (author)
- Univ Basel, Dept Psychol, Div Mol Neurosci, CH-4055 Basel, Switzerland.;Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.;Univ Basel, Psychiat Univ Clin, CH-4055 Basel, Switzerland.;Univ Basel, Dept Biozentrum, Life Sci Training Facil, CH-4056 Basel, Switzerland.
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- de Quervain, DJF (author)
- Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.;Univ Basel, Psychiat Univ Clin, CH-4055 Basel, Switzerland.;Univ Basel, Dept Psychol, Div Cognit Neurosci, CH-4055 Basel, Switzerland.,Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.,Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet Epidemiol Psychiat, Heidelberg, Germany.
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- Rietschel, M (author)
- Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet Epidemiol Psychiat, Heidelberg, Germany.
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- Schumann, G (author)
- Kings Coll London, Ctr Populat Neurosci & Stratified Med PONS, London, England.;Kings Coll London, MRC SGDP Ctr, Inst Psychiat Psychol & Neurosci, London, England.
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- Tost, H (author)
- Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany.
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- Witt, SH (author)
- Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet Epidemiol Psychiat, Heidelberg, Germany.,Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany.;Univ Hosp Bonn, Bonn, Germany.;Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.;Univ Basel, Dept Biomed, Basel, Switzerland.;Univ Basel, Inst Med Genet & Pathol, Human Genom Res Grp, Basel, Switzerland.;Univ Basel, Div Med Genet, Dept Biomed, Basel, Switzerland.;Univ Hosp Basel, Basel, Switzerland.
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- Zink, M (author)
- Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany.;Dist Hosp Mittelfranken, Dept Psychiat Psychotherapy & Psychosomat, Ansbach, Germany.
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- Meyer-Lindenberg, A (author)
- Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany.
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- Bettella, F (author)
- Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.
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- Brandt, CL (author)
- Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.
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- Clarke, TK (author)
- Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland.
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- Coynel, D (author)
- Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.;Univ Basel, Dept Psychol, Div Cognit Neurosci, CH-4055 Basel, Switzerland.
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Degenhardt, F (author)
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- Djurovic, S (author)
- Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.;Oslo Univ Hosp, Dept Med Genet, Oslo, Norway.
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- Eisenacher, S (author)
- Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany.,Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, KG Jebsen Ctr Psychosis Res,Div Mental Hlth & Add, Oslo, Norway.,Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland.
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- Fastenrath, M (author)
- Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.;Univ Basel, Dept Psychol, Div Cognit Neurosci, CH-4055 Basel, Switzerland.
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- Fatouros-Bergman, H (author)
- Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.
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- Forstner, AJ (author)
- Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany.;Univ Hosp Bonn, Bonn, Germany.;Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.;Univ Basel, Dept Biomed, Human Genom Res Grp, Basel, Switzerland.;Univ Basel, Dept Psychiat UPK, Basel, Switzerland.;Univ Hosp Basel, Inst Med Genet & Pathol, Basel, Switzerland.
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Frank, J (author)
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- Gambi, F (author)
- G DAnnunzio Univ Chieti Pescara, Dept Neurosci Imaging & Clin Sci, Pescara, Italy.
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- Gelao, B (author)
- Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.
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- Geschwind, L (author)
- Univ Basel, Dept Psychol, Div Mol Neurosci, CH-4055 Basel, Switzerland.;Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.
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- Di Giannantonio, M (author)
- G DAnnunzio Univ Chieti Pescara, Dept Neurosci Imaging & Clin Sci, Pescara, Italy.;Natl Hlth Trust, Dept Mental Hlth, Chieti, Italy.
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- Di Giorgio, A (author)
- Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.;Fdn Casa Sollievo Sofferenza IRCCS San Giovanni R, San Giovanni Rotondo, Italy.
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- Hartman, CA (author)
- Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot regulat, Dept Psychiat, Groningen, Netherlands.
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- Heilmann-Heimbach, S (author)
- Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.
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Herms, S (author)
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- Hoekstra, PJ (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Child & Adolescent Psychiat, Groningen, Netherlands.
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- Hoffmann, P (author)
- Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany.;Univ Hosp Bonn, Bonn, Germany.;Univ Bonn, Dept Genom, Life & Brain Ctr, Bonn, Germany.;Univ Basel, Dept Biomed, Basel, Switzerland.;Univ Basel, Inst Med Genet & Pathol, Human Genom Res Grp, Basel, Switzerland.;Univ Basel, Div Med Genet, Dept Biomed, Basel, Switzerland.;Univ Hosp Basel, Basel, Switzerland.
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- Hoogman, M (author)
- Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Nijmegen, Netherlands.;Radboudumc, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.
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- Jonsson, EG (author)
- Karolinska Institutet,Univ Oslo, Dept Psychol, Oslo, Norway.;Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
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- Loos, E (author)
- Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.;Univ Basel, Dept Psychol, Div Cognit Neurosci, CH-4055 Basel, Switzerland.
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- Maggioni, E (author)
- Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.;Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Neurosci & Mental Hlth, Milan, Italy.
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- Oosterlaan, J (author)
- Emma Childrens Hosp, Acad Med Ctr, Amsterdam, Netherlands.
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Papalino, M (author)
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- Rampino, A (author)
- Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.
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Romaniuk, L (author)
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- Selvaggi, P (author)
- Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.;Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Neuroimaging, London, England.
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- Sepede, G (author)
- Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.;G DAnnunzio Univ Chieti Pescara, Dept Neurosci Imaging & Clin Sci, Pescara, Italy.
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Sonderby, IE (author)
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- Spalek, K (author)
- Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.;Univ Basel, Dept Psychol, Div Cognit Neurosci, CH-4055 Basel, Switzerland.
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Sussmann, JE (author)
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Thompson, PM (author)
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- Vasquez, AA (author)
- Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Nijmegen, Netherlands.;Radboud Univ Nijmegen, Dept Psychiat, Med Ctr, Nijmegen, Netherlands.
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- Vogler, C (author)
- Univ Basel, Dept Psychol, Div Mol Neurosci, CH-4055 Basel, Switzerland.;Univ Basel, Transfac Res Platform Mol & Cognit Neurosci, Basel, Switzerland.
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- Whalley, H (author)
- Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland.
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- Farde, L (author)
- Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.
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- Flyckt, L (author)
- Karolinska Institutet
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- Engberg, G (author)
- Karolinska Institutet
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- Erhardt, S (author)
- Karolinska Institutet
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- Fatouros-Bergman, H (author)
- Karolinska Institutet
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- Cervenka, S (author)
- Karolinska Institutet
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- Schwieler, L (author)
- Karolinska Institutet,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
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Agartz, (author)
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- Collste, K (author)
- Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.
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- Victorsson, P (author)
- Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.
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- Malmqvist, A (author)
- Karolinska Institutet
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- Hedberg, M (author)
- Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
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- Orhan, F (author)
- Karolinska Institutet,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
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Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden. (creator_code:org_t)
- 2019-01-17
- 2019
- English.
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In: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 9:1, s. 12-
- Related links:
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https://www.nature.c...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://kipublication...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Schizophrenia is a severe mental disorder characterized by numerous subtle changes in brain structure and function. Machine learning allows exploring the utility of combining structural and functional brain magnetic resonance imaging (MRI) measures for diagnostic application, but this approach has been hampered by sample size limitations and lack of differential diagnostic data. Here, we performed a multi-site machine learning analysis to explore brain structural patterns of T1 MRI data in 2668 individuals with schizophrenia, bipolar disorder or attention-deficit/ hyperactivity disorder, and healthy controls. We found reproducible changes of structural parameters in schizophrenia that yielded a classification accuracy of up to 76% and provided discrimination from ADHD, through it lacked specificity against bipolar disorder. The observed changes largely indexed distributed grey matter alterations that could be represented through a combination of several global brain-structural parameters. This multi-site machine learning study identified a brain-structural signature that could reproducibly differentiate schizophrenia patients from controls, but lacked specificity against bipolar disorder. While this currently limits the clinical utility of the identified signature, the present study highlights that the underlying alterations index substantial global grey matter changes in psychotic disorders, reflecting the biological similarity of these conditions, and provide a roadmap for future exploration of brain structural alterations in psychiatric patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Schwarz, E
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Doan, NT
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Pergola, G
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Westlye, LT
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Kaufmann, T
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Wolfers, T
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show more...
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Brecheisen, R
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Quarto, T
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Ing, AJ
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Di Carlo, P
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Gurholt, TP
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Harms, RL
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Noirhomme, Q
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Moberget, T
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Agartz, I
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Andreassen, OA
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Bellani, M
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Bertolino, A
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Blasi, G
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Brambilla, P
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Buitelaar, JK
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Cervenka, Simon
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Flyckt, L
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Frangou, S
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Franke, B
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Hall, J
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Heslenfeld, DJ
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Kirsch, P
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McIntosh, AM
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Nothen, MM
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Papassotiropoulo ...
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de Quervain, DJF
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Rietschel, M
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Schumann, G
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Tost, H
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Witt, SH
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Zink, M
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Meyer-Lindenberg ...
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Bettella, F
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Brandt, CL
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Clarke, TK
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Coynel, D
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Degenhardt, F
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Djurovic, S
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Eisenacher, S
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Fastenrath, M
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Fatouros-Bergman ...
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Forstner, AJ
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Frank, J
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Gambi, F
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Gelao, B
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Geschwind, L
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Di Giannantonio, ...
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Di Giorgio, A
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Hartman, CA
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Heilmann-Heimbac ...
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Herms, S
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Hoekstra, PJ
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Hoffmann, P
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Hoogman, M
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Jonsson, EG
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Loos, E
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Maggioni, E
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Oosterlaan, J
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Papalino, M
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Rampino, A
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Romaniuk, L
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Selvaggi, P
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Sepede, G
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Sonderby, IE
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Spalek, K
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Sussmann, JE
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Thompson, PM
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Vasquez, AA
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Vogler, C
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Whalley, H
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Farde, L
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Engberg, G
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Erhardt, S
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Cervenka, S
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Schwieler, L
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Agartz,
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Collste, K
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Victorsson, P
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Malmqvist, A
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Hedberg, M
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Orhan, F
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Translational ps ...
- By the university
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Karolinska Institutet
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Uppsala University