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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003823naa a2200385 4500
001oai:DiVA.org:umu-42613
003SwePub
008110411s2010 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-426132 URI
0247 a https://doi.org/10.1016/j.vaccine.2009.12.0012 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Conlan, J Wayneu NRC, Kanada4 aut
2451 0a Differential ability of novel attenuated targeted deletion mutants of Francisella tularensis subspecies tularensis strain SCHU S4 to protect mice against aerosol challenge with virulent bacteria :b effects of host background and route of immunization
264 1b Elsevier BV,c 2010
338 a print2 rdacarrier
520 a Francisella tularensis subspecies tularensis is a highly virulent facultative intracellular pathogen of humans and a potential biological weapon. A live vaccine strain, F. tularensis LVS, was developed more than 50 years ago by pragmatic attenuation of a strain of the less virulent holarctica subspecies. LVS was demonstrated to be highly effective in human volunteers who were exposed to intradermal challenge with fully virulent subsp. tularensis, but was less effective against aerosol exposure. LVS faces regulatory hurdles that to date have prevented its licensure for general use. Therefore, a better defined and more effective vaccine is being sought. To this end we have created gene deletion mutants in the virulent subsp. tularensis strain and tested them for their ability to elicit a protective immune response against systemic or aerosol challenge with the highly virulent wild-type subsp. tularensis strain, SCHU S4. Both oral and intradermal (ID) primary vaccination routes were assessed in BALB/c and C3H/HeN mice as was oral boosting. One SCHU S4 mutant missing the heat shock gene, clpB, was significantly more attenuated than LVS whereas a double deletion mutant missing genes FTT0918 and capB was as attenuated as LVS. In general mice immunized with SCHU S4DeltaclpB were significantly better protected against aerosol challenge than mice immunized with LVS. A single ID immunization of BALB/c mice with SCHU S4DeltaclpB was at least as effective as any other regimen examined. Mice immunized with SCHU S4Delta0918DeltacapB were generally protected to a similar degree as mice immunized with LVS. A preliminary examination of immune responses to vaccination with LVS, SCHU S4DeltaclpB, or SCHU S4Delta0918DeltacapB provided no obvious correlate to their relative efficacies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653 a Francisella tularensis; Mutants; Vaccines; Aerosol
7001 a Shen, Hua4 aut
7001 a Golovliov, Igor,d 1958-u Umeå universitet,Klinisk bakteriologi,Sjöstedt ; Arcum4 aut0 (Swepub:umu)igrgov98
7001 a Zingmark, Carl,d 1975-u Umeå universitet,Klinisk bakteriologi,Sjöstedt4 aut0 (Swepub:umu)cazi0001
7001 a Oyston, Petra CF4 aut
7001 a Chen, Wangxue4 aut
7001 a House, Robert V4 aut
7001 a Sjöstedt, Anders,d 1957-u Umeå universitet,Klinisk bakteriologi4 aut0 (Swepub:umu)ansj0004
7102 a NRC, Kanadab Klinisk bakteriologi4 org
7730 t Vaccined : Elsevier BVg 28:7, s. 1824-1831q 28:7<1824-1831x 0264-410Xx 1873-2518
8564 u https://europepmc.org/articles/pmc2822029?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42613
8564 8u https://doi.org/10.1016/j.vaccine.2009.12.001

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