Augmenting inpatient treatment for post-traumatic stress disorder with a computerised cognitive bias modification procedure targeting appraisals (CBM-App): protocol for a randomised controlled trial

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Fältnamn	Indikatorer	Metadata
000		04676naa a2200421 4500
001		oai:DiVA.org:uu-405279
003		SwePub
008		200228s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:139047839
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4052792 URI
024	7	a https://doi.org/10.1136/bmjopen-2017-0199642 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1390478392 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Woud, Marcella L.u Ruhr Univ Bochum, Mental Hlth Res & Treatment Ctr, Dept Psychol, Bochum, Germany4 aut
245	1 0	a Augmenting inpatient treatment for post-traumatic stress disorder with a computerised cognitive bias modification procedure targeting appraisals (CBM-App) :b protocol for a randomised controlled trial
264		c 2018-06-30
264	1	b BMJ PUBLISHING GROUP,c 2018
338		a print2 rdacarrier
520		a Introduction Influential theories of post-traumatic stress disorder (PTSD) suggest that dysfunctional appraisals of trauma play a key role in the maintenance of symptoms, and this suggestion is increasingly supported by research. Experimental studies have indicated that a simple computerised cognitive training procedure, here termed cognitive bias modification-appraisals (CBM-App), can modify trauma-relevant appraisals and reduce analogue trauma symptoms among healthy volunteers. This suggests the possibility that CBM-App could improve outcomes in PTSD via targeting the key process of dysfunctional appraisals, for example, if applied as an adjunct to treatment. Methods and analysis The study is a randomised controlled trial with two parallel arms. It is planned to randomise 80 patients admitted for treatment for PTSD to an inpatient treatment clinic to complete either sessions of CBM-App or a sham-training control condition, the peripheral vision task. Both interventions comprise eight sessions scheduled over a 2-week period and are completed in addition to the standard treatment programme in the clinic. Outcome assessment occurs pretraining, after 1 week of training, post-training, at discharge from the inpatient clinic and 6 weeks and 3 months postdischarge. The primary outcome is dysfunctional trauma-relevant appraisals at post-training, measured using a scenario completion task. Secondary outcomes include symptom measures and hair cortisol. Outcome analyses will be primarily via mixed linear models and conducted with both intention to treat and per protocol samples. Ethics and dissemination The trial has been approved by the Ethics Committee for the Faculty of Psychology, Ruhr-Universitat Bochum (approval no 204) and the Ethics Committee for the Faculty of Medicine, Ruhr-Universitat Bochum (approval no 15-5477). Results will be published in peer-reviewed journals and will inform future clinical and experimental studies into targeting maladaptive appraisals for the reduction of PTSD symptoms.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
700	1	a Blackwell, Simon E.u Ruhr Univ Bochum, Mental Hlth Res & Treatment Ctr, Dept Psychol, Bochum, Germany4 aut
700	1	a Cwik, Jan C.u Ruhr Univ Bochum, Mental Hlth Res & Treatment Ctr, Dept Psychol, Bochum, Germany4 aut
700	1	a Margraf, Juergenu Ruhr Univ Bochum, Mental Hlth Res & Treatment Ctr, Dept Psychol, Bochum, Germany4 aut
700	1	a Holmes, Emily A.u Karolinska Institutet,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden4 aut0 (Swepub:uu)emiho252
700	1	a Steudte-Schmiedgen, Susannu Tech Univ Dresden, Dept Psychol, Dresden, Germany;Tech Univ Dresden, Dept Psychotherapy & Psychosomat Med, Dresden, Germany4 aut
700	1	a Herpertz, Stephanu Ruhr Univ Bochum, LWL Univ Hosp, Dept Psychosomat Med & Psychotherapy, Bochum, Germany4 aut
700	1	a Kessler, Henriku Ruhr Univ Bochum, LWL Univ Hosp, Dept Psychosomat Med & Psychotherapy, Bochum, Germany4 aut
710	2	a Karolinska Institutetb Ruhr Univ Bochum, Mental Hlth Res & Treatment Ctr, Dept Psychol, Bochum, Germany4 org
773	0	t BMJ Opend : BMJ PUBLISHING GROUPg 8:6q 8:6x 2044-6055
856	4	u https://bmjopen.bmj.com/content/bmjopen/8/6/e019964.full.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-405279
856	4 8	u https://doi.org/10.1136/bmjopen-2017-019964
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:139047839

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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