WFRF:(Tanner A.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04464naa a2200697 4500 | |
| 001 | oai:gup.ub.gu.se/296716 | |
| 003 | SwePub | |
| 008 | 240528s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2967162 URI |
| 024 | 7 | a https://doi.org/10.1002/mds.282062 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Mollenhauer, B.4 aut |
| 245 | 1 0 | a Validation of Serum Neurofilament Light Chain as a Biomarker of Parkinson's Disease Progression |
| 264 | c 2020-08-15 | |
| 264 | 1 | b Wiley,c 2020 |
| 520 | a Background The objective of this study was to assess neurofilament light chain as a Parkinson's disease biomarker. Methods We quantified neurofilament light chain in 2 independent cohorts: (1) longitudinal cerebrospinal fluid samples from the longitudinal de novo Parkinson's disease cohort and (2) a large longitudinal cohort with serum samples from Parkinson's disease, other cognate/neurodegenerative disorders, healthy controls, prodromal conditions, and mutation carriers. Results In the Parkinson's Progression Marker Initiative cohort, mean baseline serum neurofilament light chain was higher in Parkinson's disease patients (13 +/- 7.2 pg/mL) than in controls (12 +/- 6.7 pg/mL),P= 0.0336. Serum neurofilament light chain increased longitudinally in Parkinson's disease patients versus controls (P< 0.01). Motor scores were positively associated with neurofilament light chain, whereas some cognitive scores showed a negative association. Conclusions Neurofilament light chain in serum samples is increased in Parkinson's disease patients versus healthy controls, increases over time and with age, and correlates with clinical measures of Parkinson's disease severity. Although the specificity of neurofilament light chain for Parkinson's disease is low, it is the first blood-based biomarker candidate that could support disease stratification of Parkinson's disease versus other cognate/neurodegenerative disorders, track clinical progression, and possibly assess responsiveness to neuroprotective treatments. However, use of neurofilament light chain as a biomarker of response to neuroprotective interventions remains to be assessed. (c) 2020 The Authors.Movement Disorderspublished by Wiley Periodicals LLC. on behalf of International Parkinson and Movement Disorder Society. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 653 | a Parkinson's disease | |
| 653 | a parkinsonism | |
| 653 | a cohort studies | |
| 653 | a outcome research | |
| 653 | a cerebrospinal-fluid | |
| 653 | a diagnosis | |
| 653 | a pathology | |
| 653 | a accuracy | |
| 653 | a Neurosciences & Neurology | |
| 700 | 1 | a Dakna, M.4 aut |
| 700 | 1 | a Kruse, N.4 aut |
| 700 | 1 | a Galasko, D.4 aut |
| 700 | 1 | a Foroud, T.4 aut |
| 700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
| 700 | 1 | a Schade, S.4 aut |
| 700 | 1 | a Gera, R. G.4 aut |
| 700 | 1 | a Wang, W. T.4 aut |
| 700 | 1 | a Gao, F.4 aut |
| 700 | 1 | a Frasier, M.4 aut |
| 700 | 1 | a Chahine, L. M.4 aut |
| 700 | 1 | a Coffey, C. S.4 aut |
| 700 | 1 | a Singleton, A. B.4 aut |
| 700 | 1 | a Simuni, T.4 aut |
| 700 | 1 | a Weintraub, D.4 aut |
| 700 | 1 | a Seibyl, J.4 aut |
| 700 | 1 | a Toga, A. W.4 aut |
| 700 | 1 | a Tanner, C. M.4 aut |
| 700 | 1 | a Kieburtz, K.4 aut |
| 700 | 1 | a Marek, K.4 aut |
| 700 | 1 | a Siderowf, A.4 aut |
| 700 | 1 | a Cedarbaum, J. M.4 aut |
| 700 | 1 | a Hutten, S. J.4 aut |
| 700 | 1 | a Trenkwalder, C.4 aut |
| 700 | 1 | a Graham, D.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t Movement Disordersd : Wileyg 35:11, s. 1999-2008q 35:11<1999-2008x 0885-3185x 1531-8257 |
| 856 | 4 | u https://movementdisorders.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.28206 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/296716 |
| 856 | 4 8 | u https://doi.org/10.1002/mds.28206 |
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- Schade, S.
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