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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003867naa a2200481 4500
001oai:lup.lub.lu.se:f59d5081-c271-40c3-860f-ef8fcf5b2e99
003SwePub
008230905s2023 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/f59d5081-c271-40c3-860f-ef8fcf5b2e992 URI
0247 a https://doi.org/10.1016/j.isci.2023.1069842 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Rudjord-Levann, Asha M.u University of Copenhagen4 aut
2451 0a Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1
264 1c 2023
520 a Galectins are a group of carbohydrate-binding proteins with a presumed immunomodulatory role and an elusive function on antigen-presenting cells. Here we analyzed the expression of galectin-1 and found upregulation of galectin-1 in the extracellular matrix across multiple tumors. Performing an in-depth and dynamic proteomic and phosphoproteomic analysis of human macrophages stimulated with galectin-1, we show that galectin-1 induces a tumor-associated macrophage phenotype with increased expression of key immune checkpoint protein programmed cell death 1 ligand 1 (PD-L1/CD274) and immunomodulator indoleamine 2,3-dioxygenase-1 (IDO1). Galectin-1 induced IDO1 and its active metabolite kynurenine in a dose-dependent manner through JAK/STAT signaling. In a 3D organotypic tissue model system equipped with genetically engineered tumorigenic epithelial cells, we analyzed the cellular source of galectin-1 in the extracellular matrix and found that galectin-1 is derived from epithelial and stromal cells. Our results highlight the potential of targeting galectin-1 in immunotherapeutic treatment of human cancers.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653 a Cancer
653 a Immunology
7001 a Ye, Ziluu University of Copenhagen4 aut
7001 a Hafkenscheid, Liseu University of Copenhagen4 aut
7001 a Horn, Sabrinau University of Copenhagen4 aut
7001 a Wiegertjes, Renskeu University of Copenhagen4 aut
7001 a Nielsen, Mathias A.I.u University of Copenhagen4 aut
7001 a Song, Mingu University of Copenhagen4 aut
7001 a Mathiesen, Caroline B.K.u University of Copenhagen4 aut
7001 a Stoop, Jesseu University of Copenhagen4 aut
7001 a Stowell, Seanu Brigham and Women's Hospital / Harvard Medical School4 aut
7001 a Straten, Per Thoru Copenhagen University Hospital4 aut
7001 a Leffler, Hakonu Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)mmb-hle
7001 a Vakhrushev, Sergey Y.u University of Copenhagen4 aut
7001 a Dabelsteen, Sally4 aut
7001 a Olsen, Jesper V.4 aut
7001 a Wandall, Hans H.u University of Copenhagen4 aut
7102 a University of Copenhagenb Brigham and Women's Hospital / Harvard Medical School4 org
7730 t iScienceg 26:7q 26:7x 2589-0042
8564 u http://dx.doi.org/10.1016/j.isci.2023.106984x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/f59d5081-c271-40c3-860f-ef8fcf5b2e99
8564 8u https://doi.org/10.1016/j.isci.2023.106984

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