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Sökning: WFRF:(Trägårdh Elin) > A preanalytic valid...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006109naa a2200505 4500
001oai:lup.lub.lu.se:d530a642-2c5b-4015-97ef-bc320faf931c
003SwePub
008161228s2016 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/d530a642-2c5b-4015-97ef-bc320faf931c2 URI
0247 a https://doi.org/10.2967/jnumed.116.1770302 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Anand, Aseemu Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urological cancer, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-aa18
2451 0a A preanalytic validation study of automated bone scan index : Effect on accuracy and reproducibility due to the procedural variabilities in bone scan image acquisition
264 c 2016-07-21
264 1b Society of Nuclear Medicine,c 2016
300 a 7 s.
520 a The effect of the procedural variability in image acquisition on the quantitative assessment of bone scan is unknown. Here, we have developed and performed preanalytical studies to assess the impact of the variability in scanning speed and in vendor-specific γ-camera on reproducibility and accuracy of the automated bone scan index (BSI). Methods: Two separate preanalytical studies were performed: a patient study and a simulation study. In the patient study, to evaluate the effect on BSI reproducibility, repeated bone scans were prospectively obtained from metastatic prostate cancer patients enrolled in 3 groups (Grp). In Grp1, the repeated scan speed and the γ-camera vendor were the same as that of the original scan. In Grp2, the repeated scan was twice the speed of the original scan. In Grp3, the repeated scan used a different γ-camera vendor than that used in the original scan. In the simulation study, to evaluate the effect on BSI accuracy, bone scans of a virtual phantom with predefined skeletal tumor burden (phantom-BSI) were simulated against the range of image counts (0.2, 0.5, 1.0, and 1.5 million) and separately against the resolution settings of the γ-cameras. The automated BSI was measured with a computer-automated platform. Reproducibility was measured as the absolute difference between the repeated BSI values, and accuracy was measured as the absolute difference between the observed BSI and the phantom-BSI values. Descriptive statistics were used to compare the generated data. Results: In the patient study, 75 patients, 25 in each group, were enrolled. The reproducibility of Grp2 (mean ± SD, 0.35 ± 0.59) was observed to be significantly lower than that of Grp1 (mean ± SD, 0.10 ± 0.13; P < 0.0001) and that of Grp3 (mean ± SD, 0.09 ± 0.10; P < 0.0001). However, no significant difference was observed between the reproducibility of Grp3 and Grp1 (P = 0.388). In the simulation study, the accuracy at 0.5 million counts (mean ± SD, 0.57 ± 0.38) and at 0.2 million counts (mean ± SD, 4.67 ± 0.85) was significantly lower than that observed at 1.5 million counts (mean ± SD, 0.20 ± 0.26; P < 0.0001). No significant difference was observed in the accuracy data of the simulation study with vendor-specific γ-cameras (P 5 0.266). Conclusion: In this study, we observed that the automated BSI accuracy and reproducibility were dependent on scanning speed but not on the vendor-specific γ-cameras. Prospective BSI studies should standardize scanning speed of bone scans to obtain image counts at or above 1.5 million.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
653 a Bone scan
653 a Bone scan index
653 a Imaging biomarker
653 a Metastatic prostate cancer
653 a Pre-analytical validation
7001 a Morris, Michael J.u Memorial Sloan-Kettering Cancer Center,Cornell University4 aut
7001 a Kaboteh, Rezau Sahlgrenska University Hospital4 aut
7001 a Reza Felix, Marianau Lund University,Lunds universitet,Nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Nuclear medicine, Malmö,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-mre
7001 a Trägårdh, Elinu Lund University,Lunds universitet,Klinisk fysiologi och nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Physiology and Nuclear Medicine, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)klin-etr
7001 a Matsunaga, Naofumiu Yamaguchi University4 aut
7001 a Edenbrandt, Larsu Lund University,Lunds universitet,Nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Nuclear medicine, Malmö,Lund University Research Groups,Sahlgrenska University Hospital4 aut0 (Swepub:lu)klfy-led
7001 a Bjartell, Andersu Lund University,Lunds universitet,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,Urologi,Urological cancer, Malmö,Lund University Research Groups,Urology4 aut0 (Swepub:lu)kir-abj
7001 a Larson, Steven M.u Cornell University,Memorial Sloan-Kettering Cancer Center4 aut
7001 a Minarik, Davidu Skåne University Hospital4 aut0 (Swepub:lu)radf-dmi
7102 a Urologisk cancerforskning, Malmöb Forskargrupper vid Lunds universitet4 org
7730 t Journal of Nuclear Medicined : Society of Nuclear Medicineg 57:12, s. 1865-1871q 57:12<1865-1871x 0161-5505x 2159-662X
8564 u http://dx.doi.org/10.2967/jnumed.116.177030y FULLTEXT
8564 u http://jnm.snmjournals.org/content/57/12/1865.full.pdf
8564 8u https://lup.lub.lu.se/record/d530a642-2c5b-4015-97ef-bc320faf931c
8564 8u https://doi.org/10.2967/jnumed.116.177030

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