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A deep proteome and...
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues
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- Wang, Dongxue (författare)
- Tech Univ Munich, Chair Prote & Bioanalyt, Freising Weihenstephan, Germany.
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- Eraslan, Basak (författare)
- Tech Univ Munich, Dept Informat, Computat Biol, Garching, Germany.;Ludwig Maximilians Univ Munchen, Gene Ctr, Dept Biochem, Quantitat Biosci Munich, Munich, Germany.
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- Wieland, Thomas (författare)
- OmicScouts GmbH, Freising Weihenstephan, Germany.
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- Hallström, Björn M. (författare)
- KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
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- Hopf, Thomas (författare)
- OmicScouts GmbH, Freising Weihenstephan, Germany.
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- Zolg, Daniel Paul (författare)
- Tech Univ Munich, Chair Prote & Bioanalyt, Freising Weihenstephan, Germany.
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- Zecha, Jana (författare)
- Tech Univ Munich, Chair Prote & Bioanalyt, Freising Weihenstephan, Germany.
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- Asplund, Anna (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Li, Li-hua (författare)
- Tech Univ Munich, Chair Prote & Bioanalyt, Freising Weihenstephan, Germany.
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- Meng, Chen (författare)
- Tech Univ Munich, Chair Prote & Bioanalyt, Freising Weihenstephan, Germany.
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- Frejno, Martin (författare)
- Tech Univ Munich, Chair Prote & Bioanalyt, Freising Weihenstephan, Germany.
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- Schmidt, Tobias (författare)
- Tech Univ Munich, Chair Prote & Bioanalyt, Freising Weihenstephan, Germany.
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- Schnatbaum, Karsten (författare)
- JPT Peptide Technol GmbH, Berlin, Germany.
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- Wilhelm, Mathias (författare)
- Tech Univ Munich, Chair Prote & Bioanalyt, Freising Weihenstephan, Germany.
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- Pontén, Fredrik (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk och experimentell patologi
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- Uhlén, Mathias (författare)
- KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
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- Gagneur, Julien (författare)
- Tech Univ Munich, Dept Informat, Computat Biol, Garching, Germany.
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- Hahne, Hannes (författare)
- OmicScouts GmbH, Freising Weihenstephan, Germany.
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- Kuster, Bernhard (författare)
- Tech Univ Munich, Chair Prote & Bioanalyt, Freising Weihenstephan, Germany.;CIPSM, Munich, Germany.
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Tech Univ Munich, Chair Prote & Bioanalyt, Freising Weihenstephan, Germany Tech Univ Munich, Dept Informat, Computat Biol, Garching, Germany.;Ludwig Maximilians Univ Munchen, Gene Ctr, Dept Biochem, Quantitat Biosci Munich, Munich, Germany. (creator_code:org_t)
- 2019-02-18
- 2019
- Engelska.
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Ingår i: Molecular Systems Biology. - : WILEY. - 1744-4292 .- 1744-4292. ; 15:2
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Genome-, transcriptome- and proteome-wide measurements provide insights into how biological systems are regulated. However, fundamental aspects relating to which human proteins exist, where they are expressed and in which quantities are not fully understood. Therefore, we generated a quantitative proteome and transcriptome abundance atlas of 29 paired healthy human tissues from the Human Protein Atlas project representing human genes by 18,072 transcripts and 13,640 proteins including 37 without prior protein-level evidence. The analysis revealed that hundreds of proteins, particularly in testis, could not be detected even for highly expressed mRNAs, that few proteins show tissue-specific expression, that strong differences between mRNA and protein quantities within and across tissues exist and that protein expression is often more stable across tissues than that of transcripts. Only 238 of 9,848 amino acid variants found by exome sequencing could be confidently detected at the protein level showing that proteogenomics remains challenging, needs better computational methods and requires rigorous validation. Many uses of this resource can be envisaged including the study of gene/protein expression regulation and biomarker specificity evaluation.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Nyckelord
- human proteome
- human transcriptome
- proteogenomics
- quantitative mass spectrometry
- RNA-Seq
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Wang, Dongxue
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Eraslan, Basak
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Wieland, Thomas
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Hallström, Björn ...
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Hopf, Thomas
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Zolg, Daniel Pau ...
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visa fler...
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Zecha, Jana
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Asplund, Anna
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Li, Li-hua
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Meng, Chen
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Frejno, Martin
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Schmidt, Tobias
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Schnatbaum, Kars ...
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Wilhelm, Mathias
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Pontén, Fredrik
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Uhlén, Mathias
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Gagneur, Julien
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Hahne, Hannes
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Kuster, Bernhard
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biokemi och mole ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Bioinformatik oc ...
- Artiklar i publikationen
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Molecular System ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Uppsala universitet