Structural changes induced by electroconvulsive therapy are associated with clinical outcome

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Structural changes induced by electroconvulsive therapy are associated with clinical outcome

Mulders, Peter C.R. (författare): Radboud University Medical Center,Radboud University Nijmegen

Llera, Alberto (författare): Radboud University Nijmegen

Beckmann, Christian F. (författare): University of Oxford,Radboud University Nijmegen

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Vandenbulcke, Mathieu (författare): Catholic University of Leuven,University Hospitals Leuven

Stek, Max (författare): Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam,GGZ inGeest Specialized Mental Health Care

Sienaert, Pascal (författare): Catholic University of Leuven,University Hospitals Leuven

Redlich, Ronny (författare): University of Münster

Petrides, Georgios (författare): Feinstein Institute for Medical Research,Hofstra University,The Zucker Hillside Hospital

Oudega, Mardien Leoniek (författare): GGZ inGeest Specialized Mental Health Care,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam

Oltedal, Leif (författare): Haukeland University Hospital,University of Bergen

Oedegaard, Ketil J. (författare): University of Bergen,Haukeland University Hospital

Narr, Katherine L. (författare): University of California, Los Angeles

Magnusson, Peter O. (författare): Lund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups

Kessler, Ute (författare): Haukeland University Hospital,University of Bergen

Jorgensen, Anders (författare): University of Copenhagen

Espinoza, Randall (författare): University of California, Los Angeles

Enneking, Verena (författare): University of Münster

Emsell, Louise (författare): University Hospitals Leuven,Catholic University of Leuven

Dols, Annemieke (författare): Vrije Universiteit Amsterdam,GGZ inGeest Specialized Mental Health Care,Amsterdam UMC - Vrije Universiteit Amsterdam

Dannlowski, Udo (författare): University of Münster

Bolwig, Tom G. (författare): Copenhagen University Hospital

Bartsch, Hauke (författare): University of California, San Diego,Haukeland University Hospital

Argyelan, Miklos (författare): The Zucker Hillside Hospital,Hofstra University,Feinstein Institute for Medical Research

Anand, Amit (författare): Cleveland Clinic Foundation

Abbott, Christopher C. (författare): University of New Mexico

van Eijndhoven, Philip F.P. (författare): Radboud University Medical Center,Radboud University Nijmegen

Tendolkar, Indira (författare): University Hospital Essen,Radboud University Medical Center,Radboud University Nijmegen

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Elsevier BV, 2020
2020
Engelska 9 s.
Ingår i: Brain Stimulation. - : Elsevier BV. - 1935-861X. ; 13:3, s. 696-704

Relaterad länk:: http://dx.doi.org/10... (free); visa fler...; https://doi.org/10.1...; https://lup.lub.lu.s...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Background: Electroconvulsive therapy (ECT) is the most effective treatment option for major depressive disorder, so understanding whether its clinical effect relates to structural brain changes is vital for current and future antidepressant research. Objective: To determine whether clinical response to ECT is related to structural volumetric changes in the brain as measured by structural magnetic resonance imaging (MRI) and, if so, which regions are related to this clinical effect. We also determine whether a similar model can be used to identify regions associated with electrode placement (unilateral versus bilateral ECT). Methods: Longitudinal MRI and clinical data (Hamilton Depression Rating Scale) was collected from 10 sites as part of the Global ECT-MRI research collaboration (GEMRIC). From 192 subjects, relative changes in 80 (sub)cortical areas were used as potential features for classifying treatment response. We used recursive feature elimination to extract relevant features, which were subsequently used to train a linear classifier. As a validation, the same was done for electrode placement. We report accuracy as well as the structural coefficients of regions included in the discriminative spatial patterns obtained. Results: A pattern of structural changes in cortical midline, striatal and lateral prefrontal areas discriminates responders from non-responders (75% accuracy, p < 0.001) while left-sided mediotemporal changes discriminate unilateral from bilateral electrode placement (81% accuracy, p < 0.001). Conclusions: The identification of a multivariate discriminative pattern shows that structural change is relevant for clinical response to ECT, but this pattern does not include mediotemporal regions that have been the focus of electroconvulsive therapy research so far.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)

Nyckelord

Depression
Electroconvulsive therapy
Major depressive disorder
MRI

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