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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006987naa a2200637 4500
001oai:DiVA.org:uu-369755
003SwePub
008181217s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3697552 URI
0247 a https://doi.org/10.1126/sciadv.aat58692 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Brynildsrud, Ola B.u Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway4 aut
2451 0a Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation
264 1b AMER ASSOC ADVANCEMENT SCIENCE,c 2018
338 a print2 rdacarrier
520 a On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in the age of antibiotics, mutations conferring antimicrobial resistance overwhelmingly emerged locally (at the level of nations), with minimal cross-border transmission of resistance. The latter finding was found to reflect the relatively recent emergence of these mutations, as a similar degree of local restriction was observed for susceptible variants emerging on comparable time scales. The restricted international transmission of drug-resistant TB suggests that containment efforts at the level of individual countries could be successful.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
7001 a Pepperell, Caitlin S.u Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Div Infect Dis, Madison, WI 53726 USA;Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Microbiol & Immunol, Madison, WI 53726 USA4 aut
7001 a Suffys, Philipu Oswaldo Cruz Inst, Lab Mol Biol Appl Mycobacteria, Ave Brasil 4365,CP 926, BR-21040360 Manguinho, RJ, Brazil4 aut
7001 a Grandjean, Louisu Imperial Coll London, Dept Paediat Infect Dis, London W2 1NY, England4 aut
7001 a Monteserin, Johanau ANLIS Carlos Malbran, Inst Nacl Enfermedades Infecciosas, Buenos Aires, DF, Argentina;Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina4 aut
7001 a Debech, Nadiau Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway4 aut
7001 a Bohlin, Jonu Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway4 aut
7001 a Alfsnes, Kristianu Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway4 aut
7001 a Pettersson, John,d 1981-u Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway; Univ Sydney, Charles Perkins Ctr Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia;Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia;Publ Hlth Agcy Sweden, Nobels Vg 18, SE-17182 Solna, Sweden4 aut0 (Swepub:uu)johpe964
7001 a Kirkeleite, Ingeridu Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway4 aut
7001 a Fandinho, Fatimau Ctr Referincia Prof Helio Fraga Jacarepagu, Lab Bacteriol Tuberculose, Estr Curic 2000, Rio De Janeiro, RJ, Brazil4 aut
7001 a da Silva, Marcia Aparecidau Ctr Referincia Prof Helio Fraga Jacarepagu, Lab Bacteriol Tuberculose, Estr Curic 2000, Rio De Janeiro, RJ, Brazil4 aut
7001 a Perdigao, Joaou Univ Lisbon, Fac Farm, Inst Invest Med, Lisbon, Portugal4 aut
7001 a Portugal, Isabelu Univ Lisbon, Fac Farm, Inst Invest Med, Lisbon, Portugal4 aut
7001 a Viveiros, Miguelu Univ Nova Lisboa, Inst Higiene & Med Trop, Unidade Microbiol Med Global Hlth & Trop Med, Lisbon, Portugal4 aut
7001 a Clark, Taaneu London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London WC1E 7HT, England;London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, London WC1E 7HT, England4 aut
7001 a Caws, Maxineu Univ Liverpool Liverpool Sch Trop Med, Dept Clin Sci, Liverpool, Merseyside, England;Birat Nepal Med Trust, Kathmandu, Nepal4 aut
7001 a Dunstan, Sarahu Univ Melbourne, Peter Doherty Inst Infect & Immun, Melbourne, Vic, Australia4 aut
7001 a Thai, Phan Vuong Khac4 aut
7001 a Lopez, Beatrizu ANLIS Carlos Malbran, Inst Nacl Enfermedades Infecciosas, Buenos Aires, DF, Argentina4 aut
7001 a Ritacco, Vivianau ANLIS Carlos Malbran, Inst Nacl Enfermedades Infecciosas, Buenos Aires, DF, Argentina;Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina4 aut
7001 a Kitchen, Andrewu Univ Iowa, Dept Anthropol, Iowa City, IA 52242 USA4 aut
7001 a Brown, Tyler S.u Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA4 aut
7001 a van Soolingen, Dicku Natl Inst Publ Hlth & Environm, Ctr Infect Dis Res Diagnost & Perinatal Screening, POB 1, NL-3720 BA Bilthoven, Netherlands4 aut
7001 a O'Neill, Mary B.u Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Microbiol & Immunol, Madison, WI 53726 USA;Univ Wisconsin, Lab Genet, Madison, WI 53706 USA;Inst Pasteur, Unit Human Evolutionary Genet, F-75015 Paris, France4 aut
7001 a Holt, Kathryn E.u London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London WC1E 7HT, England;Univ Melbourne, Dept Biochem & Mol Biol, Melbourne, Vic, Australia;Univ Melbourne, Inst Bio21, Melbourne, Vic, Australia4 aut
7001 a Feil, Edward J.u Univ Bath, Milner Ctr Evolut, Dept Biol & Biochem, Bath BA2 7AY, Avon, England4 aut
7001 a Mathema, Barunu Columbia Univ, Mailman Sch Publ Hlth, 722 West 168th St, New York, NY 10032 USA4 aut
7001 a Balloux, Francoisu UCL, UCL Genet Inst, London WC1E 6BT, England4 aut
7001 a Eldholm, Vegardu Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norway4 aut
7102 a Norwegian Inst Publ Hlth, Div Infect Dis & Environm Hlth, Lovisenberggata 8, N-0456 Oslo, Norwayb Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Div Infect Dis, Madison, WI 53726 USA;Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Microbiol & Immunol, Madison, WI 53726 USA4 org
7730 t Science Advancesd : AMER ASSOC ADVANCEMENT SCIENCEg 4:10q 4:10x 2375-2548
8564 u https://advances.sciencemag.org/content/advances/4/10/eaat5869.full.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-369755
8564 8u https://doi.org/10.1126/sciadv.aat5869

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