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Lower vitamin D is ...
Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus : Data from an international inception cohort
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- Chew, Christine (author)
- University of Manchester
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- Reynolds, John A. (author)
- University of Birmingham
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- Lertratanakul, Apinya (author)
- Northwestern University Feinberg School of Medicine
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- Wu, Peggy (author)
- Northwestern University Feinberg School of Medicine
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- Urowitz, Murray (author)
- Toronto Western Hospital
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- Gladman, Dafna D. (author)
- Toronto Western Hospital
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- Fortin, Paul R. (author)
- Laval University
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- Bae, Sang Cheol (author)
- Hanyang University Medical Center
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- Gordon, Caroline (author)
- University of Birmingham
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- Clarke, Ann E. (author)
- Cumming School of Medicine
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- Bernatsky, Sasha (author)
- McGill University
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- Hanly, John G. (author)
- Dalhousie University
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- Isenberg, David (author)
- University College London
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- Rahman, Anisur (author)
- University College London
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- Sanchez-Guerrero, Jorge (author)
- Toronto Western Hospital
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- Romero-Diaz, Juanita (author)
- Salvador Zubirán National Institute of Health Sciences and Nutrition
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- Merrill, Joan (author)
- Oklahoma Medical Research Foundation
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- Wallace, Daniel (author)
- University of California, Los Angeles
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- Ginzler, Ellen (author)
- SUNY Downstate Health Sciences University
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- Khamashta, Munther (author)
- King's College London
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- Nived, Ola (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Jönsen, Andreas (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Steinsson, Kristjan (author)
- National University Hospital of Iceland
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- Manzi, Susan (author)
- Allegheny Health Network
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- Kalunian, Ken (author)
- University of California, San Diego
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- Dooley, Mary Anne (author)
- University of North Carolina
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- Petri, Michelle (author)
- Johns Hopkins University School of Medicine
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- Aranow, Cynthia (author)
- Feinstein Institutes for Medical Research
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- Van Vollenhoven, Ronald (author)
- Academic Medical Center of University of Amsterdam (AMC)
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- Stoll, Thomas (author)
- Kantonsspital Schaffhausen
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- Alarcón, Graciela S. (author)
- University of Alabama at Birmingham School of Medicine
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- Lim, S. Sam (author)
- Emory University
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- Ruiz-Irastorza, Guillermo (author)
- Biocruces Bizkaia Health Research Institute
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- Peschken, Christine A. (author)
- University of Manitoba
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- Askanase, Anca D. (author)
- Columbia University
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- Kamen, Diane L. (author)
- Medical University of South Carolina
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- Inanç, Murat (author)
- Istanbul University
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- Ramsey-Goldman, Rosalind (author)
- Northwestern University Feinberg School of Medicine
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- Bruce, Ian N. (author)
- University of Manchester
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(creator_code:org_t)
- 2021-02-08
- 2021
- English 11 s.
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In: Rheumatology (United Kingdom). - : Oxford University Press (OUP). - 1462-0324 .- 1462-0332. ; 60:10, s. 4737-4747
- Related links:
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http://dx.doi.org/10...
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https://discovery.uc...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objectives: Vitamin D (25(OH)D) deficiency and metabolic syndrome (MetS) may both contribute to increased cardiovascular risk in SLE. We aimed to examine the association of demographic factors, SLE phenotype, therapy and vitamin D levels with MetS and insulin resistance. Methods: The Systemic Lupus International Collaborating Clinics (SLICC) enrolled patients recently diagnosed with SLE (<15 months) from 33 centres across 11 countries from 2000. Clinical, laboratory and therapeutic data were collected. Vitamin D level was defined according to tertiles based on distribution across this cohort, which were set at T1 (10-36 nmol/l), T2 (37-60 nmol/l) and T3 (61-174 nmol/l). MetS was defined according to the 2009 consensus statement from the International Diabetes Federation. Insulin resistance was determined using the HOMA-IR model. Linear and logistic regressions were used to assess the association of variables with vitamin D levels. Results: Of the 1847 patients, 1163 (63%) had vitamin D measured and 398 (34.2%) subjects were in the lowest 25(OH)D tertile. MetS was present in 286 of 860 (33%) patients whose status could be determined. Patients with lower 25(OH)D were more likely to have MetS and higher HOMA-IR. The MetS components, hypertension, hypertriglyceridemia and decreased high-density lipoprotein (HDL) were all significantly associated with lower 25(OH)D. Increased average glucocorticoid exposure was associated with higher insulin resistance. Conclusions: MetS and insulin resistance are associated with lower vitamin D in patients with SLE. Further studies could determine whether vitamin D repletion confers better control of these cardiovascular risk factors and improve long-term outcomes in SLE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Cardiovascular disease
- Epidemiology
- Systemic lupus erythematosus
- Vitamin D
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Chew, Christine
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Reynolds, John A ...
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Lertratanakul, A ...
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Wu, Peggy
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Urowitz, Murray
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Gladman, Dafna D ...
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show more...
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Fortin, Paul R.
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Bae, Sang Cheol
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Gordon, Caroline
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Clarke, Ann E.
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Bernatsky, Sasha
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Hanly, John G.
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Isenberg, David
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Rahman, Anisur
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Sanchez-Guerrero ...
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Romero-Diaz, Jua ...
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Merrill, Joan
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Wallace, Daniel
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Ginzler, Ellen
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Khamashta, Munth ...
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Nived, Ola
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Jönsen, Andreas
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Steinsson, Krist ...
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Manzi, Susan
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Kalunian, Ken
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Dooley, Mary Ann ...
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Petri, Michelle
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Aranow, Cynthia
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Van Vollenhoven, ...
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Stoll, Thomas
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Alarcón, Graciel ...
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Lim, S. Sam
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Ruiz-Irastorza, ...
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Peschken, Christ ...
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Askanase, Anca D ...
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Kamen, Diane L.
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Inanç, Murat
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Ramsey-Goldman, ...
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Bruce, Ian N.
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