Osteoprotegerin predicts cardiovascular events in patients treated with haemodialysis

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Wu Ping Hsun 1982 ) > Osteoprotegerin pre...

Osteoprotegerin predicts cardiovascular events in patients treated with haemodialysis

Wu, Ping-Hsun, 1982- (författare): Uppsala universitet,Endokrinologi och mineralmetabolism

Glerup, Rie Io (författare): Department of Nephrology, Aalborg University Hospital, Aalborg, Denmark

Svensson, My Hanna Sofia (författare): Division of Medicine, Department of Nephrology, Akershus University Hospital, Oslo, Norway;Institute of Clinical Medicine, University of Oslo, Oslo, Norway

visa fler...

Eriksson, Niclas, 1978- (författare): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)

Christensen, Jeppe Hagstrup (författare): Department of Nephrology, Aalborg University Hospital, Aalborg, Denmark

Linde, Torbjörn (författare): Uppsala universitet,Njurmedicin

Ljunggren, Östen (författare): Uppsala universitet,Endokrinologi och mineralmetabolism

Fellström, Bengt, 1947- (författare): Uppsala universitet,Njurmedicin

visa färre...

(creator_code:org_t)

2021-06-04
2021
Engelska.
Ingår i: Nephrology, Dialysis and Transplantation. - : Oxford University Press. - 0931-0509 .- 1460-2385. ; 37:6, s. 1162-1170

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Background: Disturbances in bone mineral metabolism are associated with increased mortality and cardiovascular events (CVEs). However, the association between bone-associated protein biomarkers, mortality, and CVEs independent of cytokine activation remains unknown. This study aimed to investigate bone-associated protein biomarkers, and the association with inflammatory cytokines, and cardiovascular outcomes.Methods: This prospective study enrolled hemodialysis (HD) patients in Denmark between December 2010 and March 2011. Using a proximity extension proteomics assay, nine bone-associated proteins were examined: cathepsin D (CTSD), cathepsin L1 (CTSL1), dickkopf-related protein 1 (Dkk-1), fibroblast growth factor 23 (FGF-23), leptin, osteoprotegerin (OPG), receptor activator of nuclear factor kappa-Β ligand (RANKL), TNF-related apoptosis-inducing ligand (TRAIL), and TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2). The importance of the bone-associated protein markers was evaluated by a random forest algorithm (RF). The association between bone-associated proteins with all-cause death, cardiovascular death, and CVEs was analyzed in multivariable Cox models adjusted for age, gender, comorbidities, laboratory data, and dialysis duration.Results: We enrolled 331 patients (63.7% men; mean [SD] age, 65 [14.6] years) in a prospective cohort study with five years follow-up. When adjusting for confounders, CTSL1 remained associated with all-cause death, and four biomarkers were associated with CVE. However, the association between bone markers and the outcomes was attenuated after adjusting for inflammatory proteins, and just OPG remained associated with CVE in the adjusted model. Evaluating the importance of bone markers by RF, OPG was the most important marker related to CVEs. OPG also improved the prediction of CVE when added clinical information alone in integrated discrimination improvement and net reclassification improvement analyses.Discussion: OPG, a well-known bone biomarker, was associated with CVEs independent of cytokine activity. In contrast, the association between CVEs and the remaining three bone-associated proteins (TRAIL-R2, CTSD, and CTSL1) was affected by cytokine inflammation activity.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

mortality
cardiovascular disease
bone markers
inflammation
hemodialysis
Medical Science
Medicinsk vetenskap

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Nephrology, Dialysis and Transplantation (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Wu, Ping-Hsun, 1 ...; Glerup, Rie Io; Svensson, My Han ...; Eriksson, Niclas ...; Christensen, Jep ...; Linde, Torbjörn; visa fler...; Ljunggren, Östen; Fellström, Bengt ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Urologi och njur ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

Artiklar i publikationen: Nephrology, Dial ...

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se