WFRF:(Xiong Zhiwei)
Sökning: WFRF:(Xiong Zhiwei) > Screening for diffe...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04877naa a2200481 4500 | |
| 001 | oai:DiVA.org:umu-164943 | |
| 003 | SwePub | |
| 008 | 191105s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1649432 URI |
| 024 | 7 | a https://doi.org/10.1016/j.cca.2019.10.0262 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Wang, Yingu Department of Orthopedics, The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China4 aut |
| 245 | 1 0 | a Screening for differentially expressed circRNA between Kashin–Beck disease and osteoarthritis patients based on circRNA chips |
| 264 | 1 | b Elsevier,c 2020 |
| 338 | a print2 rdacarrier | |
| 520 | a Objective: This research aims to explore differentially expressed circRNA between OA and KBD and potential diagnostic biomarkers.Methods: Total RNA was extracted from 5 pairs of KBD and OA knee joint cartilage specimens, and the expression of circRNAs was analyzed by Chip Scanning Analysis. The microarray data was verified by quantitative polymerase chain reaction (qRT-PCR). CircRNA-miRNA network was constructed to predict targeting microRNAs of circRNA genes. Peripheral blood samples from 25 KBD patients and 25 OA patients were collected for verification by qRT-PCR. Diagnostic value was evaluated by the area under the receiver operator characteristic (ROC) curve.Results: A total of 1627 circRNAs were differentially expressed between OA and KBD. Five bone and joint disease-related circRNAs were chosen for qRT-PCR validation. The difference in expression profile of hsa_circRNA_0020014 was confirmed by qRT-PCR, and its circRNA-miRNA regulation network was set up. The ROC curve demonstrated that hsa_circ_0020014_CBC1 in peripheral blood could distinguish patients with KBD and OA.Conclusion: The expression profiles of circRNA were significantly different between OA and KBD. hsa_circRNA_0020014 is a potential biomarker for differential diagnosis between these two diseases. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng |
| 653 | a Kashin–Beck disease | |
| 653 | a biomarkers | |
| 653 | a circRNAs expression profiles | |
| 653 | a osteoarthritis | |
| 653 | a Clinical Chemistry | |
| 653 | a klinisk kemi | |
| 653 | a reumatologi | |
| 653 | a rheumatology | |
| 700 | 1 | a Wu, Cuiyanu School of Public Health, Health Science Center of Xi'an Jiaotong University, NHC Key Laboratory of Trace Elements and Endemic Diseases, Xi'an Jiaotong University, Xi'an, People's Republic of China4 aut |
| 700 | 1 | a Zhang, Yananu School of Public Health, Health Science Center of Xi'an Jiaotong University, NHC Key Laboratory of Trace Elements and Endemic Diseases, Xi'an Jiaotong University, Xi'an, People's Republic of China4 aut |
| 700 | 1 | a Yang, Yiminu Department of Orthopedics, The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China4 aut |
| 700 | 1 | a Ren, Zhiweiu Department of Orthopedics, The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of China4 aut |
| 700 | 1 | a Lammi, Mikko J.,d 1961-u Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),School of Public Health, Health Science Center of Xi'an Jiaotong University, NHC Key Laboratory of Trace Elements and Endemic Diseases, Xi'an Jiaotong University, Xi'an, People's Republic of China,Chondrogenic and Osteogenic Differentiation4 aut0 (Swepub:umu)mila0077 |
| 700 | 1 | a Guo, Xiongu School of Public Health, Health Science Center of Xi'an Jiaotong University, NHC Key Laboratory of Trace Elements and Endemic Diseases, Xi'an Jiaotong University, Xi'an, People's Republic of China4 aut |
| 710 | 2 | a Department of Orthopedics, The First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, People's Republic of Chinab School of Public Health, Health Science Center of Xi'an Jiaotong University, NHC Key Laboratory of Trace Elements and Endemic Diseases, Xi'an Jiaotong University, Xi'an, People's Republic of China4 org |
| 773 | 0 | t Clinica Chimica Actad : Elsevierg 501, s. 92-101q 501<92-101x 0009-8981x 1873-3492 |
| 856 | 4 | u https://www.researchsquare.com/article/rs-5489/v1.pdf?c=1631841705000 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-164943 |
| 856 | 4 8 | u https://doi.org/10.1016/j.cca.2019.10.026 |
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