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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004538naa a2200601 4500
001oai:lup.lub.lu.se:a99b97e2-baa7-4c9c-99f5-41d90b03d4c0
003SwePub
008160401s2010 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/16769092 URI
0247 a https://doi.org/10.1007/s10549-010-0769-32 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Reding, Kerryn W.4 aut
2451 0a Genetic variants on chromosome 5p12 are associated with risk of breast cancer in African American women: the Black Women's Health Study
264 c 2010-02-05
264 1b Springer Science and Business Media LLC,c 2010
520 a Two single nucleotide polymorphisms (SNPs), rs4415084, and rs10941679 on chromosome 5p12 were associated with risk of breast cancer in a recent genome-wide association study (GWAS) of women of European ancestry. Both SNPs are located in a large high-LD region and the causal variant(s) are still unknown. We conducted a nested case-control study in a cohort of African American women to replicate and narrow the region carrying the causal variant(s). We evaluated 14 tagging SNPs in a 98 kb LD block surrounding the index SNPs in 886 breast cancer cases and 1,089 controls from the Black Women's Health Study. We used the Cochran-Armitage trend test to assess association with breast cancer risk. Odds ratios were derived from logistic regression analyses adjusted for potential confounders including percent European admixture. We confirmed the reported association of rs4415084 SNP with overall risk of breast cancer (P = 0.06), and, as in the original study, observed a stronger association with estrogen receptor positive tumors (P = 0.03). We identified four other SNPs (rs6451770, rs12515012, rs13156930, and rs16901937) associated with risk of breast cancer at the nominal alpha value of 0.05; all of them were located in a 59 kb HapMap YRI LD block. After correction for multiple testing, the association with SNP rs16901937 remained significant (P permutated = 0.038). The G allele was associated with a 21% increased risk of breast cancer overall and with a 32% increase in tumors positive for both estrogen and progesterone receptors. The present results from an African ancestry (AA) population confirm the presence of breast cancer susceptibility genetic variants in the chromosome 5p12 region. We successfully used the shorter range of LD in our AA sample to refine the localization of the putative causal variant.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Contralateral
653 a Chemotherapy
653 a Breast cancer
653 a BRCA2
653 a Adjuvant therapy
653 a BRCA1
653 a Counter-matching
653 a Tamoxifen
7001 a Bernstein, Jonine L.4 aut
7001 a Langholz, Bryan M.4 aut
7001 a Bernstein, Leslie4 aut
7001 a Haile, Robert W.4 aut
7001 a Begg, Colin B.4 aut
7001 a Lynch, Charles F.4 aut
7001 a Concannon, Patrick4 aut
7001 a Borg, Åkeu Lund University,Lunds universitet,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-abo
7001 a Teraoka, Sharon N.4 aut
7001 a Törngren, Thereseu Lund University,Lunds universitet,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-tsa
7001 a Diep, Anh4 aut
7001 a Xue, Shanyan4 aut
7001 a Bertelsen, Lisbeth4 aut
7001 a Liang, Xiaolin4 aut
7001 a Reiner, Anne S.4 aut
7001 a Capanu, Marinela4 aut
7001 a Malone, Kathleen E.4 aut
7102 a Sektion Vb Institutionen för kliniska vetenskaper, Lund4 org
7730 t Breast Cancer Research and Treatmentd : Springer Science and Business Media LLCg 123:2, s. 491-498q 123:2<491-498x 1573-7217x 0167-6806
8564 u http://dx.doi.org/10.1007/s10549-010-0769-3y FULLTEXT
8564 u https://europepmc.org/articles/pmc2903659?pdf=render
8564 8u https://lup.lub.lu.se/record/1676909
8564 8u https://doi.org/10.1007/s10549-010-0769-3

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