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Sökning: WFRF:(Yetukuri L.) > PPAR gamma 2 preven...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004909naa a2200481 4500
001oai:DiVA.org:oru-70906
003SwePub
008190826s2007 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-709062 URI
0247 a https://doi.org/10.1371/journal.pgen.00300642 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Medina-Gomez, Gemau Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom4 aut
2451 0a PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
264 c 2007-04-27
264 1b Public Library of Science (PLoS),c 2007
338 a print2 rdacarrier
520 a Peroxisome proliferator activated receptor gamma 2 (PPARg2) is the nutritionally regulated isoform of PPARg. Ablation of PPARg2 in the ob/ob background, PPARg2(-/-) Lep(ob)/Lep(ob) (POKO mouse), resulted in decreased fat mass, severe insulin resistance, beta-cell failure, and dyslipidaemia. Our results indicate that the PPARg2 isoform plays an important role, mediating adipose tissue expansion in response to positive energy balance. Lipidomic analyses suggest that PPARg2 plays an important antilipotoxic role when induced ectopically in liver and muscle by facilitating deposition of fat as relatively harmless triacylglycerol species and thus preventing accumulation of reactive lipid species. Our data also indicate that PPARg2 may be required for the beta-cell hypertrophic adaptive response to insulin resistance. In summary, the PPARg2 isoform prevents lipotoxicity by (a) promoting adipose tissue expansion, (b) increasing the lipid-buffering capacity of peripheral organs, and (c) facilitating the adaptive proliferative response of beta-cells to insulin resistance.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Andra medicinska och farmaceutiska grundvetenskaper0 (SwePub)301992 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Other Basic Medicine0 (SwePub)301992 hsv//eng
7001 a Gray, Sarah L.u Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom4 aut
7001 a Yetukuri, Laxmanu Technical Research Centre of Finland (VTT), Espoo, Finland4 aut
7001 a Shimomura, Kenjuu University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom4 aut
7001 a Virtue, Samu Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom4 aut
7001 a Campbell, Marku Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom4 aut
7001 a Curtis, R. Keirau Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom4 aut
7001 a Jimenez-Linan, Mercedesu Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom4 aut
7001 a Blount, Margaretu Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom4 aut
7001 a Yeo, Giles S. H.u Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom4 aut
7001 a Lopez, Miguelu Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom4 aut
7001 a Seppänen-Laakso, Tuulikkiu Technical Research Centre of Finland (VTT), Espoo, Finland4 aut
7001 a Ashcroft, Frances M.u University Laboratory of Physiology, University of Oxford, Oxford, United Kingdom4 aut
7001 a Oresic, Matej,d 1967-u Technical Research Centre of Finland (VTT), Espoo, Finland4 aut0 (Swepub:oru)moc
7001 a Vidal-Puig, Antoniou Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdom4 aut
7102 a Department of Clinical Biochemistry, Histopathology, University of Cambridge/Addenbrooke's Hospital, Cambridge, United Kingdomb Technical Research Centre of Finland (VTT), Espoo, Finland4 org
7730 t PLOS Geneticsd : Public Library of Science (PLoS)g 3:4q 3:4x 1553-7390x 1553-7404
8564 u https://doi.org/10.1371/journal.pgen.0030064y Fulltext
8564 u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030064&type=printable
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70906
8564 8u https://doi.org/10.1371/journal.pgen.0030064

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