Blood pressure and adiposity in midlife Singaporean women

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Thu, Win Pa PaNatl Univ Singapore, Natl Univ Hosp, Yong Loo Lin Sch Med, Dept Obstet & Gynecol, Singapore 119228, Singapore. (författare)

Blood pressure and adiposity in midlife Singaporean women

Artikel/kapitelEngelska2021

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2021-01-08
Springer Nature,2021
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LIBRIS-ID:oai:DiVA.org:uu-450311
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450311URI
https://doi.org/10.1038/s41440-020-00600-2DOI

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Språk:engelska
Sammanfattning på:engelska

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Hypertension is a major risk factor for cardiac events and stroke. Visceral adipose tissue (VAT) is known to increase the risk of incident hypertension in adults. Although adiposity has been linked to markers of inflammation, few studies have examined these markers as potential mediators of the association between visceral adiposity and elevated blood pressure. We evaluated sociodemographic, reproductive, and lifestyle risk factors for elevated blood pressure among midlife Singaporean women. A total of 1189 women, with a mean age of 56.3 +/- 6.2 years, from the Integrated Women's Health Program (IWHP) at National University Hospital, Singapore were studied. Hypothesized risk factors and levels of inflammatory markers were examined in relation to systolic blood pressure (SBP) and diastolic blood pressure (DBP) using multivariable linear regression models. Prehypertension (SBP 120-139 mmHg and/or DBP 80-89 mmHg) and hypertension (SBP >= 140 mmHg and/or DBP >= 90 mmHg) were observed in 518 (43.6%) and 313 (26.3%) women, respectively. Compared to women in the lowest tertiles, women in the middle and upper tertiles of VAT had 7.1 (95% CI, 4.4, 9.8) mmHg and 10.2 (95% CI, 6.7, 13.7) mmHg higher adjusted SBP, respectively. Nulliparous older women with a lower education level and those with no or mild hot flashes also had a significantly higher adjusted SBP. No significant independent risk factors were observed for DBP. Adjustments for IL-6, TNF-alpha, and hs-CRP did not attenuate the association between VAT and SBP. In summary, we found an independent positive association between VAT and SBP. Elevated levels of inflammatory markers did not mediate the increase in SBP in women with high VAT.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Adiposity
Blood pressure
Inflammation
Menopause
Midlife

Biuppslag (personer, institutioner, konferenser, titlar ...)

Sundström Poromaa, Inger,1964-Uppsala universitet,Reproduktiv hälsa,Natl Univ Singapore, Natl Univ Hosp, Yong Loo Lin Sch Med, Dept Obstet & Gynecol, Singapore 119228, Singapore.(Swepub:uu)inspo702 (författare)
Logan, SusanNatl Univ Singapore, Natl Univ Hosp, Yong Loo Lin Sch Med, Dept Obstet & Gynecol, Singapore 119228, Singapore. (författare)
Kramer, Michael S.Natl Univ Singapore, Natl Univ Hosp, Yong Loo Lin Sch Med, Dept Obstet & Gynecol, Singapore 119228, Singapore.;McGill Univ, Fac Med, Dept Epidemiol, Montreal, PQ H3G 1Y6, Canada.;McGill Univ, Fac Med, Dept Biostat & Occupat Hlth, Montreal, PQ H3G 1Y6, Canada.;McGill Univ, Fac Med, Dept Pediat, Montreal, PQ H3G 1Y6, Canada. (författare)
Yong, Eu-LeongNatl Univ Singapore, Natl Univ Hosp, Yong Loo Lin Sch Med, Dept Obstet & Gynecol, Singapore 119228, Singapore. (författare)
Natl Univ Singapore, Natl Univ Hosp, Yong Loo Lin Sch Med, Dept Obstet & Gynecol, Singapore 119228, Singapore.Reproduktiv hälsa (creator_code:org_t)

Sammanhörande titlar

Ingår i:Hypertension Research: Springer Nature44:5, s. 561-5700916-96361348-4214

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Av författaren/redakt...: Thu, Win Pa Pa; Sundström Poroma ...; Logan, Susan; Kramer, Michael ...; Yong, Eu-Leong

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

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