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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006825naa a2201417 4500
001oai:gup.ub.gu.se/297398
003SwePub
008240528s2020 | |||||||||||000 ||eng|
024a https://gup.ub.gu.se/publication/2973982 URI
024a https://doi.org/10.1161/STROKEAHA.120.0301432 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Giustozzi, M.4 aut
2451 0a Safety of Anticoagulation in Patients Treated with Urgent Reperfusion for Ischemic Stroke Related to Atrial Fibrillation
264 1c 2020
520 a Background and Purpose: The optimal timing for starting oral anticoagulant after an ischemic stroke related to atrial fibrillation remains a challenge, mainly in patients treated with systemic thrombolysis or mechanical thrombectomy. We aimed at assessing the incidence of early recurrence and major bleeding in patients with acute ischemic stroke and atrial fibrillation treated with thrombolytic therapy and/or thrombectomy, who then received oral anticoagulants for secondary prevention. Methods: We combined the dataset of the RAF and the RAF-NOACs (Early Recurrence and Major Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation Treated With Non-Vitamin K Oral Anticoagulants) studies, which were prospective observational studies carried out from January 2012 to March 2014 and April 2014 to June 2016, respectively. We included consecutive patients with acute ischemic stroke and atrial fibrillation treated with either vitamin K antagonists or nonvitamin K oral anticoagulants. Primary outcome was the composite of stroke, transient ischemic attack, symptomatic systemic embolism, symptomatic cerebral bleeding, and major extracerebral bleeding within 90 days from the inclusion. Treated-patients were propensity matched to untreated-patients in a 1:1 ratio after stratification by baseline clinical features. Results: A total of 2159 patients were included, 564 (26%) patients received acute reperfusion therapies. After the index event, 505 (90%) patients treated with acute reperfusion therapies and 1287 of 1595 (81%) patients untreated started oral anticoagulation. Timing of starting oral anticoagulant was similar in reperfusion-treated and untreated patients (median 7.5 versus 7.0 days, respectively). At 90 days, the primary study outcome occurred in 37 (7%) patients treated with reperfusion and in 146 (9%) untreated patients (odds ratio, 0.74 [95% CI, 0.50-1.07]). After propensity score matching, risk of primary outcome was comparable between the 2 groups (odds ratio, 1.06 [95% CI, 0.53-2.02]). Conclusions: Acute reperfusion treatment did not influence the risk of early recurrence and major bleeding in patients with atrial fibrillation-related acute ischemic stroke, who started on oral anticoagulant. © 2020 Georg Thieme Verlag. All rights reserved.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a anticoagulants
653 a atrial fibrillation
653 a secondary prevention
653 a thrombectomy
653 a thrombolytic therapy
700a Acciarresi, M.4 aut
700a Agnelli, G.4 aut
700a Caso, V.4 aut
700a Bandini, F.4 aut
700a Tsivgoulis, G.4 aut
700a Yaghi, S.4 aut
700a Furie, K. L.4 aut
700a Tadi, P.4 aut
700a Becattini, C.4 aut
700a Zedde, M.4 aut
700a Abdul-Rahim, A. H.4 aut
700a Lees, K. R.4 aut
700a Alberti, A.4 aut
700a Venti, M.4 aut
700a D'Amore, C.4 aut
700a Giulia Mosconi, M.4 aut
700a Anna Cimini, L.4 aut
700a Bovi, P.4 aut
700a Carletti, M.4 aut
700a Rigatelli, A.4 aut
700a Cappellari, M.4 aut
700a Putaala, J.4 aut
700a Tomppo, L.4 aut
700a Tatlisumak, Turgutu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xtatlt
700a Marcheselli, S.4 aut
700a Pezzini, A.4 aut
700a Poli, L.4 aut
700a Padovani, A.4 aut
700a Vannucchi, V.4 aut
700a Sohn, S. I.4 aut
700a Lorenzini, G.4 aut
700a Tassi, R.4 aut
700a Guideri, F.4 aut
700a Acampa, M.4 aut
700a Martini, G.4 aut
700a Ntaios, G.4 aut
700a Athanasakis, G.4 aut
700a Makaritsis, K.4 aut
700a Karagkiozi, E.4 aut
700a Vadikolias, K.4 aut
700a Liantinioti, C.4 aut
700a Theodorou, A.4 aut
700a Halvatsiotis, P.4 aut
700a Mumoli, N.4 aut
700a Galati, F.4 aut
700a Sacco, S.4 aut
700a Tiseo, C.4 aut
700a Corea, F.4 aut
700a Ageno, W.4 aut
700a Bellesini, M.4 aut
700a Silvestrelli, G.4 aut
700a Ciccone, A.4 aut
700a Lanari, A.4 aut
700a Scoditti, U.4 aut
700a Denti, L.4 aut
700a Mancuso, M.4 aut
700a Ferrari, E.4 aut
700a Ulivi, L.4 aut
700a Orlandi, G.4 aut
700a Giannini, N.4 aut
700a Tassinari, T.4 aut
700a Luisa De Lodovici, M.4 aut
700a Rueckert, C.4 aut
700a Baldi, A.4 aut
700a Toni, D.4 aut
700a Letteri, F.4 aut
700a Giuntini, M.4 aut
700a Maria Lotti, E.4 aut
700a Flomin, Y.4 aut
700a Pieroni, A.4 aut
700a Kargiotis, O.4 aut
700a Karapanayiotides, T.4 aut
700a Monaco, S.4 aut
700a Maimone Baronello, M.4 aut
700a Csiba, L.4 aut
700a Szabó, L.4 aut
700a Chiti, A.4 aut
700a Giorli, E.4 aut
700a Del Sette, M.4 aut
700a Imberti, D.4 aut
700a Zabzuni, D.4 aut
700a Doronin, B.4 aut
700a Volodina, V.4 aut
700a Michel, P.4 aut
700a Vanacker, P.4 aut
700a Barlinn, K.4 aut
700a Barlinn, J.4 aut
700a Deleu, D.4 aut
700a Gourbali, V.4 aut
700a Paciaroni, M.4 aut
700a Masotti, L.4 aut
710a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi4 org
773t Strokeg 51:8, s. 2347-2354q 51:8<2347-2354x 0039-2499
8564 8u https://gup.ub.gu.se/publication/297398
8564 8u https://doi.org/10.1161/STROKEAHA.120.030143

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