Comparative analysis of gene expression profiles between the normal human cartilage and the one with endemic osteoarthritis.

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Wang, Wei-ZhouFaculty of Public Health, College of Medicine, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Xi'an Jiaotong University, Xi'an, China; Department of Orthopedics Surgery, The Second Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, China (författare)

Comparative analysis of gene expression profiles between the normal human cartilage and the one with endemic osteoarthritis.

Artikel/kapitelEngelska2009

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Saunders Elsevier,2009
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LIBRIS-ID:oai:DiVA.org:umu-106538
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106538URI
https://doi.org/10.1016/j.joca.2008.05.008DOI

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Språk:engelska
Sammanfattning på:engelska &language:-1_t

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Ämneskategori:art swepub-publicationtype

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OBJECTIVE: To investigate the differences in gene expression profiles of adult articular cartilage with endemic osteoarthritis (OA), Kashin-Beck disease (KBD), and the same regions in the normal joint.METHODS: The messenger RNA expression profiles of articular cartilage with KBD diagnosed according to "Diagnosing Criteria of Kashin-Beck Disease in China" were compared with the normal cartilage. Total RNA isolated separately from four pairs of the KBD and normal cartilage samples were evaluated by oligonucleotide microarray analysis. The microarray data were confirmed by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) amplification and were compared with previously published experiments.RESULTS: About 4100 transcripts, which corresponded to 35% of the expressed transcripts, showed >or=twofold differences in expression between the cartilage tissues in pairs. Approximately 2% of the expressed genes (79, 55 genes expressed in KBD>normal; 24 genes expressed in KBDCONCLUSION: Differences between KBD cartilage and the normal exhibited a similar pattern among the four pairs examined, indicating the presence of common mechanisms mainly including chondrocyte metabolism and apoptosis that contribute to cartilage destruction in KBD.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Ortopedi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Orthopaedics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
NATURVETENSKAP Biologi Genetik hsv//swe
NATURAL SCIENCES Biological Sciences Genetics hsv//eng
NATURVETENSKAP Biologi Cellbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
Kashin-Beck disease
cartilage
gene expression
microarray
cell research
cellforskning
genetik
Genetics
ortopedi
Orthopaedics

Biuppslag (personer, institutioner, konferenser, titlar ...)

Guo, XiongFaculty of Public Health, College of Medicine, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Xi'an Jiaotong University, Xi'an, China (författare)
Duan, ChenFaculty of Public Health, College of Medicine, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Xi'an Jiaotong University, Xi'an, China (författare)
Ma, Wei JuanFaculty of Public Health, College of Medicine, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Xi'an Jiaotong University, Xi'an, China (författare)
Zhang, Y GFaculty of Public Health, College of Medicine, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Xi'an Jiaotong University, Xi'an, China (författare)
Xu, PFaculty of Public Health, College of Medicine, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Xi'an Jiaotong University, Xi'an, China (författare)
Gao, Z QDepartment of Orthopedics Surgery, The Second Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, China (författare)
Wang, Z FFaculty of Public Health, College of Medicine, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Xi'an Jiaotong University, Xi'an, China (författare)
Yan, HNational Engineering Research Center for Miniaturized Detection Systems, Northwest University, Xi'an, China (författare)
Zhang, Y FNational Engineering Research Center for Miniaturized Detection Systems, Northwest University, Xi'an, China (författare)
Yu, Y XFaculty of Public Health, College of Medicine, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Xi'an Jiaotong University, Xi'an, China (författare)
Chen, J CDepartment of Orthopedics Surgery, The Second Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, China (författare)
Lammi, Mikko,1961-Department of Biosciences, Applied Biotechnology, University of Kuopio, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group(Swepub:umu)mila0077 (författare)
Faculty of Public Health, College of Medicine, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Xi'an Jiaotong University, Xi'an, China; Department of Orthopedics Surgery, The Second Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an, ChinaFaculty of Public Health, College of Medicine, Key Laboratory of Environment and Gene Related Diseases of Ministry Education, Xi'an Jiaotong University, Xi'an, China (creator_code:org_t)

Sammanhörande titlar

Ingår i:Osteoarthritis and Cartilage: Saunders Elsevier17:1, s. 83-901063-45841522-9653

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Av författaren/redakt...: Wang, Wei-Zhou; Guo, Xiong; Duan, Chen; Ma, Wei Juan; Zhang, Y G; Xu, P; visa fler...; Gao, Z Q; Wang, Z F; Yan, H; Zhang, Y F; Yu, Y X; Chen, J C; Lammi, Mikko, 19 ...; visa färre...

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