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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006549naa a2200805 4500
001oai:lup.lub.lu.se:a3bb558f-a028-44a5-88aa-2154baba8cc5
003SwePub
008190611s2019 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-161610
0247 a https://lup.lub.lu.se/record/a3bb558f-a028-44a5-88aa-2154baba8cc52 URI
0247 a https://doi.org/10.1093/carcin/bgy1872 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1616102 URI
040 a (SwePub)lud (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Dai, Junchengu Nanjing Medical University4 aut
2451 0a Systematic analyses of regulatory variants in DNase I hypersensitive sites identified two novel lung cancer susceptibility loci
264 c 2019-01-09
264 1b Oxford University Press (OUP),c 2019
300 a 9 s.
520 a DNase I hypersensitive sites (DHS) are abundant in regulatory elements, such as promoter, enhancer and transcription factor binding sites. Many studies have revealed that disease-associated variants were concentrated in DHS-related regions. However, limited studies are available on the roles of DHS-related variants in lung cancer. In this study, we performed a large-scale case-control study with 20 871 lung cancer cases and 15 971 controls to evaluate the associations between regulatory genetic variants in DHS and lung cancer susceptibility. The expression quantitative trait loci (eQTL) analysis and pathway-enrichment analysis were performed to identify the possible target genes and pathways. In addition, we performed motif-based analysis to explore the lung-cancer-related motifs using sequence kernel association test. Two novel variants, rs186332 in 20q13.3 (C>T, odds ratio [OR] = 1.17, 95% confidence interval [95% CI]: 1.10-1.24, P = 8.45 × 10-7) and rs4839323 in 1p13.2 (T>C, OR = 0.92, 95% CI: 0.89-0.95, P = 1.02 × 10-6) showed significant association with lung cancer risk. The eQTL analysis suggested that these two SNPs might regulate the expression of MRGBP and SLC16A1, respectively. What's more, the expression of both MRGBP and SLC16A1 was aberrantly elevated in lung tumor tissues. The motif-based analysis identified 10 motifs related to the risk of lung cancer (P < 1.71 × 10-4). Our findings suggested that variants in DHS might modify lung cancer susceptibility through regulating the expression of surrounding genes. This study provided us a deeper insight into the roles of DHS-related genetic variants for lung cancer.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
7001 a Li, Zhihuau First Affiliated Hospital of Nanjing Medical University4 aut
7001 a Amos, Christopher I.u Dartmouth College4 aut
7001 a Hung, Rayjean J.u Sinai Health System,University of Toronto4 aut
7001 a Tardon, Adoninau CIBER Epidemiology and Public Health (CIBERESP),University of Oviedo4 aut
7001 a Andrew, Angeline S.u Norris Cotton Cancer Center4 aut
7001 a Chen, Chuu Fred Hutchinson Cancer Research Center,Harvard University,Vanderbilt University4 aut
7001 a Christiani, David C.u Harvard University4 aut
7001 a Albanes, Demetriosu National Cancer Institute, USA4 aut
7001 a van der Heijden, Erik H.F.M.u Radboud University Medical Center4 aut
7001 a Duell, Eric J.u Catalan Institute of Oncology4 aut
7001 a Rennert, Gadu Carmel Medical Center4 aut
7001 a Mckay, James D.u International Agency for Research on Cancer, World Health Organization4 aut
7001 a Yuan, Jian Minu University of Pittsburgh Cancer Institute4 aut
7001 a Field, John K.u University of Liverpool4 aut
7001 a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)smi-jma
7001 a Grankvist, Kjellu Umeå universitet,Umeå University,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002
7001 a Le Marchand, Loicu University of Hawaii at Manoa4 aut
7001 a Teare, M. Dawnu University of Sheffield4 aut
7001 a Schabath, Matthew B.u H. Lee Moffitt Cancer Center & Research Institute4 aut
7001 a Aldrich, Melinda C.u Vanderbilt University4 aut
7001 a Tsao, Ming Soundu Princess Margaret Hospital University of Toronto4 aut
7001 a Lazarus, Philipu Washington State University4 aut
7001 a Lam, Stephenu British Columbia Cancer Agency4 aut
7001 a Bojesen, Stig E.u University of Copenhagen,Gentofte Hospital4 aut
7001 a Arnold, Susanneu University of Kentucky Medical Center4 aut
7001 a Wu, Xifengu University of Texas4 aut
7001 a Haugen, Aageu National Institute of Occupational Health, Norway4 aut
7001 a Janout, Vladimiru Palacký University4 aut
7001 a Johansson, Mikaelu Umeå universitet,Umeå University,Onkologi4 aut0 (Swepub:umu)mijo0025
7001 a Brhane, Yonathanu University of Toronto,Sinai Health System4 aut
7001 a Fernandez-Somoano, Anau University of Oviedo,CIBER Epidemiology and Public Health (CIBERESP)4 aut
7001 a Kiemeney, Lambertus A.u Radboud University Medical Center4 aut
7001 a Davies, Michael P.A.u University of Liverpool4 aut
7001 a Zienolddiny, Shanbehu National Institute of Occupational Health, Norway4 aut
7001 a Hu, Zhibinu Nanjing Medical University4 aut
7001 a Shen, Hongbingu Nanjing Medical University4 aut
7102 a Nanjing Medical Universityb First Affiliated Hospital of Nanjing Medical University4 org
7730 t Carcinogenesisd : Oxford University Press (OUP)g 40:3, s. 432-440q 40:3<432-440x 0143-3334x 1460-2180
8564 u http://dx.doi.org/10.1093/carcin/bgy187y FULLTEXT
8564 u https://europepmc.org/articles/pmc6783905?pdf=render
8564 8u https://lup.lub.lu.se/record/a3bb558f-a028-44a5-88aa-2154baba8cc5
8564 8u https://doi.org/10.1093/carcin/bgy187
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161610

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