WFRF:(van Duijnhoven Fränzel J B)
Sökning: WFRF:(van Duijnhoven Fränzel J B) > (2020-2024) > Two genome-wide int...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 19404naa a2201273 4500 | |
| 001 | oai:DiVA.org:umu-225944 | |
| 003 | SwePub | |
| 008 | 240612s2024 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2259442 URI |
| 024 | 7 | a https://doi.org/10.1126/sciadv.adk31212 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Drew, David A.u Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States4 aut |
| 245 | 1 0 | a Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer |
| 264 | 1 | b American Association for the Advancement of Science (AAAS),c 2024 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Regular, long-term aspirin use may act synergistically with genetic variants, particularly those in mechanistically relevant pathways, to confer a protective effect on colorectal cancer (CRC) risk. We leveraged pooled data from 52 clinical trial, cohort, and case-control studies that included 30,806 CRC cases and 41,861 controls of European ancestry to conduct a genome-wide interaction scan between regular aspirin/nonsteroidal anti-inflammatory drug (NSAID) use and imputed genetic variants. After adjusting for multiple comparisons, we identified statistically significant interactions between regular aspirin/NSAID use and variants in 6q24.1 (top hit rs72833769), which has evidence of influencing expression of TBC1D7 (a subunit of the TSC1-TSC2 complex, a key regulator of MTOR activity), and variants in 5p13.1 (top hit rs350047), which is associated with expression of PTGER4 (codes a cell surface receptor directly involved in the mode of action of aspirin). Genetic variants with functional impact may modulate the chemopreventive effect of regular aspirin use, and our study identifies putative previously unidentified targets for additional mechanistic interrogation. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 700 | 1 | a Kim, Andre E.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Lin, Yiu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut |
| 700 | 1 | a Qu, Conghuiu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut |
| 700 | 1 | a Morrison, Johnu Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Lewinger, Juan Pablou Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Kawaguchi, Ericu Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Wang, Junu Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Fu, Yubou Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Zemlianskaia, Nataliau Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Díez-Obrero, Virginiau Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain4 aut |
| 700 | 1 | a Bien, Stephanie A.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut |
| 700 | 1 | a Dimou, Nikiu Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France4 aut |
| 700 | 1 | a Albanes, Demetriusu Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States4 aut |
| 700 | 1 | a Baurley, James W.u Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut |
| 700 | 1 | a Wu, Anna H.u Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Buchanan, Daniel D.u Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, Parkville, United States; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, United States; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Parkville, Australia4 aut |
| 700 | 1 | a Potter, John D.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand4 aut |
| 700 | 1 | a Prentice, Ross L.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut |
| 700 | 1 | a Harlid, Sophia,d 1978-u Umeå universitet,Onkologi4 aut0 (Swepub:umu)soha0105 |
| 700 | 1 | a Arndt, Volkeru Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
| 700 | 1 | a Barry, Elizabeth L.u Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA4 aut |
| 700 | 1 | a Berndt, Sonja I.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States4 aut |
| 700 | 1 | a Bouras, Emmanouilu Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, Department of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece4 aut |
| 700 | 1 | a Brenner, Hermannu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
| 700 | 1 | a Budiarto, Arifu Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut |
| 700 | 1 | a Burnett-Hartman, Andreau Institute for Health Research, Kaiser Permanente Colorado, CO, Denver, United States4 aut |
| 700 | 1 | a Campbell, Peter T.u Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States4 aut |
| 700 | 1 | a Carreras-Torres, Robertu Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Salt, 17190 Girona, Spain4 aut |
| 700 | 1 | a Casey, Grahamu Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States4 aut |
| 700 | 1 | a Chang-Claude, Jennyu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany4 aut |
| 700 | 1 | a Conti, David V.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Devall, Matthew A Mu Department of Family Medicine, University of Virginia, VA, Charlottesville, United States4 aut |
| 700 | 1 | a Figueiredo, Jane C.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Gruber, Stephen B.u Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, CA, USA; Center for Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA4 aut |
| 700 | 1 | a Gsur, Andreau Center for Cancer Research, Medical University Vienna, Vienna, Austria4 aut |
| 700 | 1 | a Gunter, Marc J.u Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France; Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom4 aut |
| 700 | 1 | a Harrison, Tabitha A.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut |
| 700 | 1 | a Hidaka, Akihisau Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut |
| 700 | 1 | a Hoffmeister, Michaelu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
| 700 | 1 | a Huyghe, Jeroen R.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut |
| 700 | 1 | a Jenkins, Mark A.u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia4 aut |
| 700 | 1 | a Jordahl, Kristina M.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States4 aut |
| 700 | 1 | a Kundaje, Anshulu Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States4 aut |
| 700 | 1 | a Le Marchand, Loicu University of Hawaii Cancer Center, HI, Honolulu, United States4 aut |
| 700 | 1 | a Li, Liu Department of Family Medicine, University of Virginia, VA, Charlottesville, United States; UVA Comprehensive Cancer Center, VA, Charlottesville, United States4 aut |
| 700 | 1 | a Lynch, Brigid M.u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia4 aut |
| 700 | 1 | a Murphy, Neilu Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France4 aut |
| 700 | 1 | a Nassir, Ramiu Department of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia4 aut |
| 700 | 1 | a Newcomb, Polly A.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States4 aut |
| 700 | 1 | a Newton, Christina C.u Department of Population Science, American Cancer Society, GA, Atlanta, United States4 aut |
| 700 | 1 | a Obón-Santacana, Mireiau Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain4 aut |
| 700 | 1 | a Ogino, Shujiu Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, MA, Boston, United States; Harvard Medical School, MA, Boston, United States; Broad Institute of MIT and Harvard, MA, Cambridge, United States4 aut |
| 700 | 1 | a Ose, Jenniferu Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut |
| 700 | 1 | a Pai, Rish K.u Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States4 aut |
| 700 | 1 | a Palmer, Julie R.u Slone Epidemiology Center at Boston University, MA, Boston, United States4 aut |
| 700 | 1 | a Papadimitriou, Nikosu Nutrition and Metabolism Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France4 aut |
| 700 | 1 | a Pardamean, Bensu Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut |
| 700 | 1 | a Pellatt, Andrew J.u Department of Cancer Medicine, University of Texas MD Anderson Cancer Center, TX, Houston, United States4 aut |
| 700 | 1 | a Peoples, Anita R.u Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut |
| 700 | 1 | a Platz, Elizabeth A.u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States4 aut |
| 700 | 1 | a Rennert, Gadu Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel4 aut |
| 700 | 1 | a Ruiz-Narvaez, Edwardu Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States4 aut |
| 700 | 1 | a Sakoda, Lori C.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States4 aut |
| 700 | 1 | a Scacheri, Peter C.u Department of Genetics and Genome Sciences, Case Western Reserve University, OH, Cleveland, United States4 aut |
| 700 | 1 | a Schmit, Stephanie L.u Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, OH, Cleveland, United States4 aut |
| 700 | 1 | a Schoen, Robert E.u Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States4 aut |
| 700 | 1 | a Stern, Mariana C.u Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Su, Yu-Ruu Biostatistics Division, Kaiser Permanente Washington Health Research Institute, WA, Seattle, United States4 aut |
| 700 | 1 | a Thomas, Duncan C.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Tian, Yuu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, China4 aut |
| 700 | 1 | a Tsilidis, Konstantinos K.u Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece4 aut |
| 700 | 1 | a Ulrich, Cornelia M.u Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut |
| 700 | 1 | a Um, Caroline Y.u Department of Population Science, American Cancer Society, GA, Atlanta, United States4 aut |
| 700 | 1 | a van Duijnhoven, Fränzel J Bu Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands4 aut |
| 700 | 1 | a van Guelpen, Bethanyu Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi4 aut0 (Swepub:umu)beyvan99 |
| 700 | 1 | a White, Emilyu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States4 aut |
| 700 | 1 | a Hsu, Liu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States4 aut |
| 700 | 1 | a Moreno, Victoru Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine and Health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain4 aut |
| 700 | 1 | a Peters, Ulrikeu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, School of Public Health, University of Washington, WA, Seattle, United States4 aut |
| 700 | 1 | a Chan, Andrew T.u Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States4 aut |
| 700 | 1 | a Gauderman, W Jamesu Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
| 710 | 2 | a Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United Statesb Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 org |
| 773 | 0 | t Science Advancesd : American Association for the Advancement of Science (AAAS)g 10:22q 10:22x 2375-2548 |
| 856 | 4 | u https://doi.org/10.1126/sciadv.adk3121y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1868807/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-225944 |
| 856 | 4 8 | u https://doi.org/10.1126/sciadv.adk3121 |
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