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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004350naa a2200517 4500
001oai:DiVA.org:su-82437
003SwePub
008121114s2012 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-824372 URI
0247 a https://doi.org/10.1158/1055-9965.EPI-12-03042 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hochstenbach, Kevin4 aut
2451 0a Global gene expression analysis in cord blood reveals gender specific differences in response to carcinogenic exposure in utero
264 1c 2012
338 a print2 rdacarrier
500 a AuthorCount:18;
520 a Background: It has been suggested that fetal carcinogenic exposure might lead to predisposition to develop cancer during childhood or in later life possibly through modulation of the fetal transcriptome. Because gender effects in the incidence of childhood cancers have been described, we hypothesized differences at the transcriptomic level in cord blood between male and female newborns as a consequence of fetal carcinogenic exposure. The objective was to investigate whether transcriptomic responses to dietary genotoxic and nongenotoxic carcinogens show gender-specific mechanisms-of-action relevant for chemical carcinogenesis. Methods: Global gene expression was applied in umbilical cord blood samples, the CALUX-assay was used for measuring dioxin(-like), androgen(-like), and estrogen(-like) internal exposure, and acrylamide-hemoglobin adduct levels were determined by mass spectrometry adduct-FIRE-procedure (TM). To link gene expression to an established phenotypic biomarker of cancer risk, micronuclei frequencies were investigated. Results: While exposure levels did not differ between sexes at birth, important gender-specific differences were observed in gene expressions associated with these exposures linked with cell cycle, the immune system and more general cellular processes such as posttranslation. Moreover, oppositely correlating leukemia/lymphoma genes between male and female newborns were identified in relation to the different biomarkers of exposure that might be relevant to male-specific predisposition to develop these cancers in childhood. Conclusions/Impact: This study reveals different transcriptomic responses to environmental carcinogens between the sexes. In particular, male-specific TNF-alpha-NF-kB signaling upon dioxin exposure and activation of the Wnt-pathway in boys upon acrylamide exposure might represent possible mechanistic explanations for gender specificity in the incidence of childhood leukemia.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
7001 a van Leeuwen, Danitsja M.4 aut
7001 a Gmuender, Hans4 aut
7001 a Gottschalk, Ralf W.4 aut
7001 a Lovik, Martinus4 aut
7001 a Granum, Berit4 aut
7001 a Nygaard, Unni4 aut
7001 a Namork, Ellen4 aut
7001 a Kirsch-Volders, Micheline4 aut
7001 a Decordier, Ilse4 aut
7001 a Loock, Kim Vande4 aut
7001 a Besselink, Harrie4 aut
7001 a Törnqvist, Margaretau Stockholms universitet,Avdelningen för miljökemi4 aut0 (Swepub:su)mt
7001 a von Stedingk, Hansu Stockholms universitet,Avdelningen för miljökemi4 aut0 (Swepub:su)hvons
7001 a Rydberg, Peru Stockholms universitet,Avdelningen för miljökemi4 aut0 (Swepub:su)rydberg
7001 a Kleinjans, Jos C. S.4 aut
7001 a van Loveren, Henk4 aut
7001 a van Delft, Joost H. M.4 aut
7102 a Stockholms universitetb Avdelningen för miljökemi4 org
7730 t Cancer Epidemiology, Biomarkers and Preventiong 21:10, s. 1756-1767q 21:10<1756-1767x 1055-9965x 1538-7755
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-82437
8564 8u https://doi.org/10.1158/1055-9965.EPI-12-0304

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