The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)

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Fältnamn	Indikatorer	Metadata
000		10305naa a2200985 4500
001		oai:DiVA.org:uu-407978
003		SwePub
008		200403s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:umu-169125
009		oai:prod.swepub.kib.ki.se:143127158
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4079782 URI
024	7	a https://doi.org/10.1158/0008-5472.CAN-19-28502 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1691252 URI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1431271582 URI
040		a (SwePub)uud (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Trabert, Brittonu NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA4 aut
245	1 0	a The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles :b An Analysis from the Ovarian Cancer Cohort Consortium (OC3)
264	1	b AMER ASSOC CANCER RESEARCH,c 2020
338		a print2 rdacarrier
520		a Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial ovarian cancer (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used to estimate multivariable-adjusted HRs between lifetime ovulatory cycles (LOC) and its components and ovarian cancer risk overall and by histotype. Women in the 90th percentile of LOC (>514 cycles) were almost twice as likely to be diagnosed with ovarian cancer than women in the 10th percentile (<294) [HR (95% confidence interval): 1.92 (1.60-2.30)]. Risk increased 14% per 5-year increase in LOC (60 cycles) [(1.10-1.17)]; this association remained after adjustment for LOC components: number of pregnancies and oral contraceptive use [1.08 (1.04-1.12)]. The association varied by histotype, with increased risk of serous [1.13 (1.09-1.17)], endometrioid [1.20 (1.10-1.32)], and clear cell [1.37 (1.18-1.58)], but not mucinous [0.99 (0.88-1.10), P-heterogeneity = 0.01] tumors. Heterogeneity across histotypes was reduced [P-heterogeneity = 0.15] with adjustment for LOC components [1.08 serous, 1.11 endometrioid, 1.26 clear cell, 0.94 mucinous]. Although the 10-year absolute risk of ovarian cancer is small, it roughly doubles as the number of LOC rises from approximately 300 to 500. The consistency and linearity of effects strongly support the hypothesis that each ovulation leads to small increases in the risk of most ovarian cancers, a risk that cumulates through life, suggesting this as an important area for identifying intervention strategies.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
700	1	a Tworoger, Shelley S.u H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA4 aut
700	1	a O'Brien, Katie M.u NIEHS, Epidemiol Branch, NIH, Durham, NC USA4 aut
700	1	a Townsend, Mary K.u H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA4 aut
700	1	a Fortner, Renee T.u German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany4 aut
700	1	a Iversen, Edwin S.u Duke Univ, Dept Stat Sci, Durham, NC USA4 aut
700	1	a Hartge, Patriciau NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA4 aut
700	1	a White, Emilyu Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA4 aut
700	1	a Amiano, Pilaru BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain;CIBER Epidemiol & Salud Publ, Madrid, Spain4 aut
700	1	a Arslan, Alan A.u NYU, Sch Med, NYU Langone Hlth, New York, NY USA;NYU, Perlmutter Canc Ctr, New York, NY USA,NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA,Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Toronto, ON, Canada,Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands4 aut
700	1	a Bernstein, Leslieu City Hope Natl Med Ctr, Duarte, CA USA4 aut
700	1	a Brinton, Louise A.u NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA4 aut
700	1	a Buring, Julie E.u Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA4 aut
700	1	a Dossus, Laureu IARC, Lyon, France4 aut
700	1	a Fraser, Gary E.u Loma Linda Univ, Loma Linda, CA 92350 USA4 aut
700	1	a Gaudet, Mia M.u Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA4 aut
700	1	a Giles, Graham G.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia4 aut
700	1	a Gram, Inger T.u Univ Tromso, Arctic Univ Norway, Dept Community Med, Tromso, Norway4 aut
700	1	a Harris, Holly R.u Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA4 aut
700	1	a Bolton, Judith Hoffmanu Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA;Johns Hopkins Sch Med, Baltimore, MD USA4 aut
700	1	a Idahl, Annika,d 1965-u Umeå universitet,Obstetrik och gynekologi,Umea Univ, Dept Clin Sci Obstet & Gynecol, Umea, Sweden4 aut0 (Swepub:umu)anid0002
700	1	a Jones, Michael E.u Inst Canc Res, Div Genet & Epidemiol, London, England4 aut
700	1	a Kaaks, Rudolfu German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany4 aut
700	1	a Kirsh, Victoria A.u Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Toronto, ON, Canada4 aut
700	1	a Knutsen, Synnove F.u Loma Linda Univ, Loma Linda, CA 92350 USA4 aut
700	1	a Kvaskoff, Marinau Univ Paris Saclay, Univ Paris Sud, UVSQ, INSERM,Fac Med,CESP, Villejuif, France;Gustave Roussy, Villejuif, France4 aut
700	1	a Lacey, James, Vu City Hope Natl Med Ctr, Duarte, CA USA4 aut
700	1	a Lee, I-Minu Brigham & Womens Hosp, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA4 aut
700	1	a Milne, Roger L.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia4 aut
700	1	a Onland-Moret, N. Charlotteu Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands4 aut
700	1	a Overvad, Kimu Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark4 aut
700	1	a Patel, Alpa, Vu Amer Canc Soc, Behav & Epidemiol Res Grp, Atlanta, GA 30329 USA4 aut
700	1	a Peters, Ulrikeu Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA4 aut
700	1	a Poynter, Jenny N.u Univ Minnesota, Div Pediat Epidemiol & Clin Res, Minneapolis, MN USA4 aut
700	1	a Riboli, Eliou Imperial Coll London, Sch Publ Hlth, London, England4 aut
700	1	a Robien, Kimu George Washington Univ, Milken Inst Sch Publ Hlth, Dept Exercise & Nutr Sci, Washington, DC USA4 aut
700	1	a Rohan, Thomas E.u Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA4 aut
700	1	a Sandler, Dale P.u NIEHS, Epidemiol Branch, NIH, Durham, NC USA4 aut
700	1	a Schairer, Catherineu NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA4 aut
700	1	a Schouten, Leo J.u Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands4 aut
700	1	a Setiawan, Veronica W.u Univ Southern Calif, Los Angeles, CA 90007 USA4 aut
700	1	a Swerdlow, Anthony J.u Inst Canc Res, Div Genet & Epidemiol, London, England;Inst Canc Res, Div Breast Canc Res, London, England4 aut
700	1	a Travis, Ruth C.u Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England4 aut
700	1	a Trichopoulou, Antoniau Hellen Hlth Fdn, Athens, Greece4 aut
700	1	a van den Brandt, Piet A.u Maastricht Univ, GROW Sch Oncol & Dev Biol, Maastricht, Netherlands4 aut
700	1	a Visvanathan, Kalau Univ Tromso, Arctic Univ Norway, Dept Community Med, Tromso, Norway4 aut
700	1	a Wilkens, Lynne R.u Univ Hawaii, Populat Sci Pacific Program Canc Epidemiol, Canc Ctr, Honolulu, HI 96822 USA4 aut
700	1	a Wolk, Alicjau Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Stockholm, Sweden4 aut0 (Swepub:uu)alwol516
700	1	a Zeleniuch-Jacquotte, Anneu NYU, Sch Med, NYU Langone Hlth, New York, NY USA;NYU, Perlmutter Canc Ctr, New York, NY USA4 aut
700	1	a Wentzensen, Nicolasu NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA4 aut
710	2	a NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USAb H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA4 org
773	0	t Cancer Researchd : AMER ASSOC CANCER RESEARCHg 80:5, s. 1210-1218q 80:5<1210-1218x 0008-5472x 1538-7445
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-407978
856	4 8	u https://doi.org/10.1158/0008-5472.CAN-19-2850
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-169125
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:143127158

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Av författaren/redakt...: Trabert, Britton; Tworoger, Shelle ...; O'Brien, Katie M ...; Townsend, Mary K ...; Fortner, Renee T ...; Iversen, Edwin S ...; visa fler...; Hartge, Patricia; White, Emily; Amiano, Pilar; Arslan, Alan A.; Bernstein, Lesli ...; Brinton, Louise ...; Buring, Julie E.; Dossus, Laure; Fraser, Gary E.; Gaudet, Mia M.; Giles, Graham G.; Gram, Inger T.; Harris, Holly R.; Bolton, Judith H ...; Idahl, Annika, 1 ...; Jones, Michael E ...; Kaaks, Rudolf; Kirsh, Victoria ...; Knutsen, Synnove ...; Kvaskoff, Marina; Lacey, James, V; Lee, I-Min; Milne, Roger L.; Onland-Moret, N. ...; Overvad, Kim; Patel, Alpa, V; Peters, Ulrike; Poynter, Jenny N ...; Riboli, Elio; Robien, Kim; Rohan, Thomas E.; Sandler, Dale P.; Schairer, Cather ...; Schouten, Leo J.; Setiawan, Veroni ...; Swerdlow, Anthon ...; Travis, Ruth C.; Trichopoulou, An ...; van den Brandt, ...; Visvanathan, Kal ...; Wilkens, Lynne R ...; Wolk, Alicja; Zeleniuch-Jacquo ...; Wentzensen, Nico ...; visa färre...

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