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Biological and stru...
Biological and structural characterization of murine TRALI antibody reveals increased Fc-mediated complement activation
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- Van Der Laan, Eveline A.N.Zeeuw (författare)
- Sanquin Research,Academic Medical Center of University of Amsterdam (AMC)
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- Van Der Velden, Saskia (författare)
- Academic Medical Center of University of Amsterdam (AMC),Sanquin Research
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- Bentlage, Arthur E.H. (författare)
- Sanquin Research,Academic Medical Center of University of Amsterdam (AMC)
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- Larsen, Mads D. (författare)
- Academic Medical Center of University of Amsterdam (AMC),Sanquin Research
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- Van Osch, Thijs L.J. (författare)
- Sanquin Research,Academic Medical Center of University of Amsterdam (AMC)
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- Mok, Juk Yee (författare)
- Sanquin Reagents
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- Brasser, Giso (författare)
- Sanquin Reagents
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- Geerdes, Dionne M. (författare)
- Sanquin Reagents
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- Koeleman, Carolien A.M. (författare)
- Leiden University Medical Centre
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- Nouta, Jan (författare)
- Leiden University Medical Centre
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- Semple, John W. (författare)
- Lund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine
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- Porcelijn, Leendert (författare)
- Sanquin Diagnostic Services
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- Van Esch, Wim J.E. (författare)
- Sanquin Reagents
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- Wuhrer, Manfred (författare)
- Leiden University Medical Centre
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- Van Der Schoot, C. Ellen (författare)
- Sanquin Research,Academic Medical Center of University of Amsterdam (AMC)
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- Vidarsson, Gestur (författare)
- Academic Medical Center of University of Amsterdam (AMC),Sanquin Research
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- Kapur, Rick (författare)
- Academic Medical Center of University of Amsterdam (AMC),Sanquin Research
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(creator_code:org_t)
- 2020-08-18
- 2020
- Engelska 11 s.
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Ingår i: Blood Advances. - : American Society of Hematology. - 2473-9529 .- 2473-9537. ; 4:16, s. 3875-3885
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Abstract
Ämnesord
Stäng
- Transfusion-related acute lung injury (TRALI) remains a leading cause of transfusionrelated deaths. In most cases, anti-leukocyte antibodies in the transfusion product trigger TRALI, but not all anti-leukocyte antibodies cause TRALI. It has been shown that the anti-major histocompatibility complex (MHC) class I antibody 34-1-2S (anti-H-2Kd) causes TRALI in BALB/c mice (MHC class I haplotype H-2Kd), whereas SF1.1.10 (anti-H-2Kd) does not. In C57BL/6 mice (MHC class I haplotype H-2Kb), TRALI only occurs when anti-MHC class I antibody AF6-88.5.5.3 (anti-H-2Kb) is administered together with a high dose of 34-1-2S. It remains unknown which specific antibody characteristics are responsible for eliciting TRALI. We therefore investigated several biological and structural features of 34-1-2S compared with other anti-MHC class I antibodies, which on their own do not cause TRALI: SF1.1.10 and AF6-88.5.5.3. No substantial differences were observed between the TRALIcausing 34-1-2S and the TRALI-resistant SF1.1.10 regarding binding affinity to H-2Kd. Regarding binding affinity to H-2Kb, only AF6-88.5.5.3 potently bound to H-2Kb, whereas 34-1-2S exhibited weak but significant cross-reactivity. Furthermore, the binding affinity to FcgRs as well as the Fc glycan composition seemed to be similar for all antibodies. Similar Fc glycosylation profiles were also observed for human TRALI-causing donor anti-HLA antibodies compared with human anti-HLA antibodies from control donors. 34-1-2S, however, displayed superior complement activation capacity, which was fully Fc dependent and not significantly dependent on Fc glycosylation. We conclude that TRALI induction is not correlated with Fab- A nd Fc-binding affinities for antigen and FcgRs, respectively, nor with the composition of Fc glycans; but increased Fc-mediated complement activation is correlated with TRALI induction.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Van Der Laan, Ev ...
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Van Der Velden, ...
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Bentlage, Arthur ...
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Larsen, Mads D.
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Van Osch, Thijs ...
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Mok, Juk Yee
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Brasser, Giso
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Geerdes, Dionne ...
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Koeleman, Caroli ...
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Nouta, Jan
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Semple, John W.
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Porcelijn, Leend ...
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Van Esch, Wim J. ...
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Wuhrer, Manfred
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Van Der Schoot, ...
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Vidarsson, Gestu ...
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Kapur, Rick
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