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Therapeutic role of...
Therapeutic role of interleukin-1 receptor antagonist in pancreatic diseases : mendelian randomization study
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- Yuan, Shuai (författare)
- Karolinska Institutet
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- Miao, Yuyang (författare)
- Karolinska Inst, Dept Med, Huddinge, Sweden.;Tianjin Med Univ, Tianjin Geriatr Inst, Gen Hosp, Dept Geriatr, Tianjin, Peoples R China.
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- Ruan, Xixian (författare)
- Cent South Univ, Dept Gastroenterol, Changsha, Peoples R China.
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- Chen, Jie (författare)
- Zhejiang Univ, Affiliated Hosp 2, Ctr Clin Big Data & Analyt, Sch Publ Hlth,Dept Big Data Hlth Sci,Sch Med, Hangzhou, Peoples R China.
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- Li, Xue (författare)
- Zhejiang Univ, Affiliated Hosp 2, Ctr Clin Big Data & Analyt, Sch Publ Hlth,Dept Big Data Hlth Sci,Sch Med, Hangzhou, Peoples R China.
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- Larsson, Susanna C. (författare)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Dept Med, Huddinge, Sweden;Tianjin Med Univ, Tianjin Geriatr Inst, Gen Hosp, Dept Geriatr, Tianjin, Peoples R China. (creator_code:org_t)
- Frontiers Media S.A. 2023
- 2023
- Engelska.
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Ingår i: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 14
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
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- Background: The interleukin-1 pathway has been linked to pancreatic diseases. We applied the Mendelian randomization approach to explore whether higher interleukin-1 receptor antagonist (IL-1RA) levels reduce the risk of acute and chronic pancreatitis and pancreatic cancer.Methods: Genetic variants associated with blood IL-1RA levels at the genome-wide significance level and located 5MB downstream or upstream of the IL1RN gene were extracted from a genome-wide meta-analysis of 21,758 participants. After pruning, genetic variants without linkage disequilibrium were used as genetic instrument for IL-1RA. Summary-level data on acute and chronic pancreatitis and pancreatic cancer were obtained from the UK Biobank and FinnGen studies. The associations were meta-analyzed for one outcome from two sources.Results: Genetically predicted higher levels of IL-1RA were associated with a lower risk of acute and chronic pancreatitis and pancreatic cancer. In the meta-analysis of UK Biobank and FinnGen, the combined odds ratio was 0.87 (95% confidence interval [CI] 0.77-0.97, P=0.003) for acute pancreatitis, 0.73 (95% CI 0.65-0.82, P=2.93x10-8) for chronic pancreatitis, and 0.86 (95% CI 0.77-0.96, P=0.009) for pancreatic cancer per one standard deviation increment in genetically predicted levels of IL-1RA.Conclusion: This study suggests a protective role of IL-1RA in three major pancreatic diseases, which hints the therapeutic potentials of IL-1RA in pancreatic diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- interleukin-1 receptor antagonist
- mendelian randomization
- pancreatic disease
- acute pancreatitis (AP)
- chronic pancreatitis
- pancreatic cancer
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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