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Interaction between...
Interaction between plasma phospholipid odd-chain fatty acids and GAD65 autoantibodies on the incidence of adult-onset diabetes : the EPIC-InterAct case–cohort study
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- Lampousi, Anna Maria (författare)
- Karolinska Institutet,Karolinska Institute,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Carlsson, Sofia (författare)
- Karolinska Institutet,Karolinska Institute,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Löfvenborg, Josefin E. (författare)
- Karolinska Institutet,Karolinska Institute,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Risk and Benefit Assessment, Swedish Food Agency, Uppsala, Sweden
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- Cabrera-Castro, Natalia (författare)
- Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain
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- Chirlaque, María Dolores (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Health and Social Sciences, Murcia University, Murcia, Spain,Murcia Regional Health Council
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- Fagherazzi, Guy (författare)
- Deep Digital Phenotyping Research Unit, Department of Precision Health, Luxembourg Institute of Health, Strassen, Luxembourg
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- Franks, Paul W. (författare)
- Umeå universitet,Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Clinical Research Center, Skåne University Hospital, Lund University, Malmö, Sweden,Allmänmedicin
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- Hampe, Christiane S. (författare)
- Department of Medicine, University of Washington School of Medicine, WA, Seattle, United States
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- Jakszyn, Paula (författare)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain; Blanquerna School of Health Sciences, Ramon Llull University, Barcelona, Spain,Catalan Institute of Oncology
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- Koulman, Albert (författare)
- Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; National Institute for Health Research Biomedical Research Centre Core Nutritional Biomarker Laboratory, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
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- Kyrø, Cecilie (författare)
- Danish Cancer Society Research Center, Copenhagen, Denmark
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- Moreno-Iribas, Conchi (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
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- Nilsson, Peter M. (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Department of Clinical Sciences, Clinical Research Center, Skåne University Hospital, Lund University, Malmö, Sweden
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- Panico, Salvatore (författare)
- Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
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- Papier, Keren (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- van der Schouw, Yvonne T. (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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- Schulze, Matthias B. (författare)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany,University of Potsdam,German Institute of Human Nutrition
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Zamora-Ros, Raul (författare)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain
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- Forouhi, Nita G. (författare)
- Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
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- Sharp, Stephen J. (författare)
- Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
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- Rolandsson, Olov (författare)
- Umeå universitet,Umeå University,Allmänmedicin
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- Wareham, Nicholas J. (författare)
- Medical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
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(creator_code:org_t)
- Springer Science+Business Media B.V. 2023
- 2023
- Engelska 12 s.
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Ingår i: Diabetologia. - : Springer Science+Business Media B.V.. - 0012-186X .- 1432-0428. ; 66:8, s. 1460-1471
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Aims/hypothesis: Islet autoimmunity may progress to adult-onset diabetes. We investigated whether circulating odd-chain fatty acids (OCFA) 15:0 and 17:0, which are inversely associated with type 2 diabetes, interact with autoantibodies against GAD65 (GAD65Ab) on the incidence of adult-onset diabetes. Methods: We used the European EPIC-InterAct case–cohort study including 11,124 incident adult-onset diabetes cases and a subcohort of 14,866 randomly selected individuals. Adjusted Prentice-weighted Cox regression estimated HRs and 95% CIs of diabetes in relation to 1 SD lower plasma phospholipid 15:0 and/or 17:0 concentrations or their main contributor, dairy intake, among GAD65Ab-negative and -positive individuals. Interactions between tertiles of OCFA and GAD65Ab status were estimated by proportion attributable to interaction (AP). Results: Low concentrations of OCFA, particularly 17:0, were associated with a higher incidence of adult-onset diabetes in both GAD65Ab-negative (HR 1.55 [95% CI 1.48, 1.64]) and GAD65Ab-positive (HR 1.69 [95% CI 1.34, 2.13]) individuals. The combination of low 17:0 and high GAD65Ab positivity vs high 17:0 and GAD65Ab negativity conferred an HR of 7.51 (95% CI 4.83, 11.69), with evidence of additive interaction (AP 0.25 [95% CI 0.05, 0.45]). Low dairy intake was not associated with diabetes incidence in either GAD65Ab-negative (HR 0.98 [95% CI 0.94, 1.02]) or GAD65Ab-positive individuals (HR 0.97 [95% CI 0.79, 1.18]). Conclusions/interpretation: Low plasma phospholipid 17:0 concentrations may promote the progression from GAD65Ab positivity to adult-onset diabetes. Graphical Abstract: [Figure not available: see fulltext.]
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Diabetes
- GAD65Ab
- Heptadecanoic
- Islet autoimmunity
- OCFA
- Pentadecanoic
- Diabetes
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Till lärosätets databas
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Lampousi, Anna M ...
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Carlsson, Sofia
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Löfvenborg, Jose ...
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Cabrera-Castro, ...
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Chirlaque, María ...
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Fagherazzi, Guy
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visa fler...
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Franks, Paul W.
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Hampe, Christian ...
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Jakszyn, Paula
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Koulman, Albert
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Kyrø, Cecilie
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Moreno-Iribas, C ...
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Nilsson, Peter M ...
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Panico, Salvator ...
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Papier, Keren
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van der Schouw, ...
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Schulze, Matthia ...
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Weiderpass, Elis ...
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Zamora-Ros, Raul
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Forouhi, Nita G.
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Sharp, Stephen J ...
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Rolandsson, Olov
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Wareham, Nichola ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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Diabetologia
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Lunds universitet
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Karolinska Institutet
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