Sökning: L773:0028 4793 OR L773:1533 4406 >
Long-Term Oxygen Th...
Long-Term Oxygen Therapy for 24 or 15 Hours per Day in Severe Hypoxemia
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- Ekström, Magnus (författare)
- Lund University,Lunds universitet,Palliativt Utvecklingscentrum,Forskargrupper vid Lunds universitet,Andfåddhet och kronisk andningssvikt,The Institute for Palliative Care,Lund University Research Groups,Breathlessness and chronic respiratory failure,Respiratory Medicine, Allergology, and Palliative Medicine, Department of Clinical Sciences in Lund, Faculty of Medicine, Lund University, Lund, Sweden; Department of Medicine, Blekinge Hospital, Karlskrona, Sweden
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- Andersson, Anders (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,COPD Center, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Papadopoulos, Savvas (författare)
- Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden
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- Kipper, Taivo (författare)
- Karlstad County Hospital, Karlstad, Sweden
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- Pedersen, Bo (författare)
- Northern Älvsborg County Hospital, Trollhättan, Sweden,Norra Älvsborgs Länssjukhus
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- Kricka, Ozren (författare)
- Linköping University Hospital, Linköping, Sweden
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- Sobrino, Pierre (författare)
- Falun Hospital, Falun, Sweden,Falun Central Hospital
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- Runold, Michael (författare)
- Department of Respiratory Medicine and Allergology, Faculty of Medicine, Karolinska University Hospital, Solna, Sweden
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- Palm, Andreas (författare)
- Uppsala University,Department of Medical Sciences, Respiratory, Allergy, and Sleep Research, Uppsala University, Uppsala, Sweden; Center for Research and Development, Gävle Hospital, Gävle, Sweden
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- Blomberg, Anders (författare)
- Umeå University,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
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- Hamed, Ranjh (författare)
- Karolinska University Hospital Huddinge, Stockholm, Sweden
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- Lindberg, Eva (författare)
- Department of Medical Sciences, Respiratory, Allergy, and Sleep Research, Uppsala University, Uppsala, Sweden
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- Sundberg, Björn (författare)
- Sundsvall-Härnösand County Hospital, Sundsvall, Sweden
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- Hadziosmanovic, Nermin (författare)
- Uppsala Clinical Research Center, Uppsala, Sweden
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- Björklund, Filip (författare)
- Lund University,Lunds universitet,Andfåddhet och kronisk andningssvikt,Forskargrupper vid Lunds universitet,Breathlessness and chronic respiratory failure,Lund University Research Groups,Respiratory Medicine, Allergology, and Palliative Medicine, Department of Clinical Sciences in Lund, Faculty of Medicine, Lund University, Lund, Sweden
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- Janson, Christer (författare)
- Department of Medical Sciences, Respiratory, Allergy, and Sleep Research, Uppsala University, Uppsala, Sweden
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- McDonald, Christine F. (författare)
- Institute for Breathing and Sleep and the Department of Respiratory and Sleep Medicine, Austin Health, Melbourne, Australia
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- Currow, David C. (författare)
- Graduate School of Medicine, Faculty of Science, Medicine, and Health, University of Wollongong, Wollongong, NSW, Australia
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- Sundh, Josefin, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Respiratory Medicine
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REDOX Collaborative Research Group, - (bidragsgivare)
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: New England Journal of Medicine. - : Massachusetts Medical Society. - 0028-4793 .- 1533-4406.
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Long-term oxygen supplementation for at least 15 hours per day prolongs survival among patients with severe hypoxemia. On the basis of a nonrandomized comparison, long-term oxygen therapy has been recommended to be used for 24 hours per day, a more burdensome regimen.METHODS: To test the hypothesis that long-term oxygen therapy used for 24 hours per day does not result in a lower risk of hospitalization or death at 1 year than therapy for 15 hours per day, we conducted a multicenter, registry-based, randomized, controlled trial involving patients who were starting oxygen therapy for chronic, severe hypoxemia at rest. The patients were randomly assigned to receive long-term oxygen therapy for 24 or 15 hours per day. The primary outcome, assessed in a time-to-event analysis, was a composite of hospitalization or death from any cause within 1 year. Secondary outcomes included the individual components of the primary outcome assessed at 3 and 12 months.RESULTS: Between May 18, 2018, and April 4, 2022, a total of 241 patients were randomly assigned to receive long-term oxygen therapy for 24 hours per day (117 patients) or 15 hours per day (124 patients). No patient was lost to follow-up. At 12 months, the median patient-reported daily duration of oxygen therapy was 24.0 hours (interquartile range, 21.0 to 24.0) in the 24-hour group and 15.0 hours (interquartile range, 15.0 to 16.0) in the 15-hour group. The risk of hospitalization or death within 1 year in the 24-hour group was not lower than that in the 15-hour group (mean rate, 124.7 and 124.5 events per 100 person-years, respectively; hazard ratio, 0.99; 95% confidence interval [CI], 0.72 to 1.36; 90% CI, 0.76 to 1.29; P = 0.007 for nonsuperiority). The groups did not differ substantially in the incidence of hospitalization for any cause, death from any cause, or adverse events.CONCLUSIONS: Among patients with severe hypoxemia, long-term oxygen therapy used for 24 hours per day did not result in a lower risk of hospitalization or death within 1 year than therapy for 15 hours per day. (Funded by the Crafoord Foundation and others; REDOX ClinicalTrials.gov number, NCT03441204.).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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Ekström, Magnus
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Andersson, Ander ...
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Papadopoulos, Sa ...
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Kipper, Taivo
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Pedersen, Bo
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Kricka, Ozren
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Sobrino, Pierre
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Runold, Michael
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Palm, Andreas
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Blomberg, Anders
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Hamed, Ranjh
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Lindberg, Eva
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Sundberg, Björn
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Hadziosmanovic, ...
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Björklund, Filip
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Janson, Christer
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McDonald, Christ ...
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Currow, David C.
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Sundh, Josefin, ...
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REDOX Collaborat ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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New England Jour ...
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Örebro universitet
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