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Growth-differentiat...
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Kempf, Tibor
(författare)
Growth-differentiation factor-15 improves risk stratification in ST-segment elevation myocardial infarction
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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2007-10-17
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Oxford University Press (OUP),2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-14703
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-14703URI
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https://doi.org/10.1093/eurheartj/ehm465DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Aims Growth-differentiation factor-15 (GDF-15) is a transforming growth factor-beta-related cytokine that is induced in the heart following ischaemia-reperfusion injury. We explored the prognostic utility of GDF-15 in patients with ST-segment elevation myocardial infarction (STEMI) receiving fibrinolytic therapy. Methods and results Circulating levels of GDF-15 were determined by an immunoradiometric assay in 741 STEMI patients who were included in the Assessment of the Safety and Efficacy of a New Thrombolytic (ASSENT)-2 and ASSENT-plus trials. About 72.7% of the patients presented with GDF-15 levels >= 1200 ng/L, the upper limit of normal in apparently healthy elderly individuals. Increased levels of GDF-15 were associated with a higher risk of death during 1-year follow-up. Mortality rates at 1 year were 2.1, 5.0, and 14.0% in patients with GDF-15 levels < 1200, 1200-1800, and > 1800 ng/L, respectively (P < 0.001). GDF-15 remained an independent predictor of mortality after adjustment for clinical variables, troponin T, and N-terminal pro-B-type natriuretic peptide (NT-proBNP). GDF-15 provided prognostic information in clinically relevant patient subgroups, defined according to age, gender, cardiovascular risk factors, haemodynamic status, and the TIMI risk score. Moreover, GDF-15 added prognostic information to the established biomarkers of adverse prognosis in STEMI, troponin T, and NT-proBNP. Conclusion GDF-15 is a new biomarker in STEMI that provides prognostic information beyond established clinical and biochemical markers.
Ämnesord och genrebeteckningar
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biomarker
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growth differentiation factor 15
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STEMI
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prognosis
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Björklund, ErikUppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)erbjo179
(författare)
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Olofsson, Sylvia,1955-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)syolo424
(författare)
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Lindahl, Bertil,1957-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)belin227
(författare)
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Allhoff, Tim
(författare)
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Peter, Timo
(författare)
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Tongers, Jörn
(författare)
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Wollert, Kai C
(författare)
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Wallentin, Lars,1943-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)larswall
(författare)
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Uppsala universitetUppsala kliniska forskningscentrum (UCR)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Heart Journal: Oxford University Press (OUP)28:23, s. 2858-28650195-668X1522-9645
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Kempf, Tibor
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Björklund, Erik
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Olofsson, Sylvia ...
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Lindahl, Bertil, ...
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Allhoff, Tim
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Peter, Timo
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Tongers, Jörn
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Wollert, Kai C
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Wallentin, Lars, ...
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European Heart J ...
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Uppsala universitet