Search: (LAR1:gu) pers:(Blennow Kaj 1958) pers:(Johnson S. C.)
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Identification of p...
Identification of plasma metabolites associated with modifiable risk factors and endophenotypes reflecting Alzheimer's disease pathology
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Dong, R. C. (author)
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Denier-Fields, D. N. (author)
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Van Hulle, C. A. (author)
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Kollmorgen, G. (author)
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Suridjan, I. (author)
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Wild, N. (author)
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Lu, Q. S. (author)
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Anderson, R. M. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Carlsson, C. M. (author)
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Johnson, S. C. (author)
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Engelman, C. D. (author)
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(creator_code:org_t)
- 2023-03-25
- 2023
- English.
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In: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284.
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Modifiable factors can influence the risk for Alzheimer's disease (AD) and serve as targets for intervention; however, the biological mechanisms linking these factors to AD are unknown. This study aims to identify plasma metabolites associated with modifiable factors for AD, including MIND diet, physical activity, smoking, and caffeine intake, and test their association with AD endophenotypes to identify their potential roles in pathophysiological mechanisms. The association between each of the 757 plasma metabolites and four modifiable factors was tested in the wisconsin registry for Alzheimer's prevention cohort of initially cognitively unimpaired, asymptomatic middle-aged adults. After Bonferroni correction, the significant plasma metabolites were tested for association with each of the AD endophenotypes, including twelve cerebrospinal fluid (CSF) biomarkers, reflecting key pathophysiologies for AD, and four cognitive composite scores. Finally, causal mediation analyses were conducted to evaluate possible mediation effects. Analyses were performed using linear mixed-effects regression. A total of 27, 3, 23, and 24 metabolites were associated with MIND diet, physical activity, smoking, and caffeine intake, respectively. Potential mediation effects include beta-cryptoxanthin in the association between MIND diet and preclinical Alzheimer cognitive composite score, hippurate between MIND diet and immediate learning, glutamate between physical activity and CSF neurofilament light, and beta-cryptoxanthin between smoking and immediate learning. Our study identified several plasma metabolites that are associated with modifiable factors. These metabolites can be employed as biomarkers for tracking these factors, and they provide a potential biological pathway of how modifiable factors influence the human body and AD risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Plasma metabolites
- MIND diet
- Physical activity
- Smoking
- Caffeine
- Alzheimer's biomarkers
- Cognition
- Mediation
- physical-activity
- cognitive decline
- tobacco smoking
- retinoic acid
- vitamin-a
- dementia
- biomarkers
- metabolomics
- midlife
- cancer
- Public
- Environmental & Occupational Health
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Dong, R. C.
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Denier-Fields, D ...
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Van Hulle, C. A.
-
Kollmorgen, G.
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Suridjan, I.
-
Wild, N.
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show more...
-
Lu, Q. S.
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Anderson, R. M.
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Carlsson, C. M.
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Johnson, S. C.
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Engelman, C. D.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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European Journal ...
- By the university
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University of Gothenburg