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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005559naa a2200865 4500
001oai:lup.lub.lu.se:8878d820-0fee-4bdf-808b-b2df4d597a7d
003SwePub
008160401s2011 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:122501356
0247 a https://lup.lub.lu.se/record/19881262 URI
0247 a https://doi.org/10.1002/ana.223212 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1225013562 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Elbaz, Alexis4 aut
2451 0a Independent and Joint Effects of the MAPT and SNCA Genes in Parkinson Disease
264 c 2011-03-09
264 1b Wiley,c 2011
520 a Objective: We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium. Methods: Participants of Caucasian ancestry were genotyped for a total of 4 SNCA (rs2583988, rs181489, rs356219, rs11931074) and 2 MAPT (rs1052553, rs242557) single nucleotide polymorphism (SNPs). Individual and joint effects of SNCA and MAPT SNPs were investigated using fixed- and random-effects logistic regression models. Interactions were studied on both a multiplicative and an additive scale, and using a case-control and case-only approach. Results: Fifteen GEO-PD sites contributed a total of 5,302 cases and 4,161 controls. All 4 SNCA SNPs and the MAPT H1-haplotype-defining SNP (rs1052553) displayed a highly significant marginal association with PD at the significance level adjusted for multiple comparisons. For SNCA, the strongest associations were observed for SNPs located at the 30 end of the gene. There was no evidence of statistical interaction between any of the 4 SNCA SNPs and rs1052553 or rs242557, neither on the multiplicative nor on the additive scale. Interpretation: This study confirms the association between PD and both SNCA SNPs and the H1 MAPT haplotype. It shows, based on a variety of approaches, that the joint action of variants in these 2 loci is consistent with independent effects of the genes without additional interacting effects. ANN NEUROL 2011; 69: 778-792
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
7001 a Ross, Owen A.4 aut
7001 a Ioannidis, John P. A.4 aut
7001 a Soto-Ortolaza, Alexandra I.4 aut
7001 a Moisan, Frederic4 aut
7001 a Aasly, Jan4 aut
7001 a Annesi, Grazia4 aut
7001 a Bozi, Maria4 aut
7001 a Brighina, Laura4 aut
7001 a Chartier-Harlin, Marie-Christine4 aut
7001 a Destee, Alain4 aut
7001 a Ferrarese, Carlo4 aut
7001 a Ferraris, Alessandro4 aut
7001 a Gibson, J. Mark4 aut
7001 a Gispert, Suzana4 aut
7001 a Hadjigeorgiou, Georgios M.4 aut
7001 a Jasinska-Myga, Barbara4 aut
7001 a Klein, Christine4 aut
7001 a Krueger, Rejko4 aut
7001 a Lambert, Jean-Charles4 aut
7001 a Lohmann, Katja4 aut
7001 a van de Loo, Simone4 aut
7001 a Loriot, Marie-Anne4 aut
7001 a Lynch, Timothy4 aut
7001 a Mellick, George D.4 aut
7001 a Mutez, Eugenie4 aut
7001 a Nilsson, Christeru Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-cni
7001 a Opala, Grzegorz4 aut
7001 a Puschmann, Andreasu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-aps
7001 a Quattrone, Aldo4 aut
7001 a Sharma, Manu4 aut
7001 a Silburn, Peter A.4 aut
7001 a Stefanis, Leonidas4 aut
7001 a Uitti, Ryan J.4 aut
7001 a Valente, Enza Maria4 aut
7001 a Vilarino-Gueell, Carles4 aut
7001 a Wirdefeldt, Karinu Karolinska Institutet4 aut
7001 a Wszolek, Zbigniew K.4 aut
7001 a Xiromerisiou, Georgia4 aut
7001 a Maraganore, Demetrius M.4 aut
7001 a Farrer, Matthew J.4 aut
7102 a Psykiatri, Lundb Sektion IV4 org
7730 t Annals of Neurologyd : Wileyg 69:5, s. 778-792q 69:5<778-792x 1531-8249x 0364-5134
8564 u http://dx.doi.org/10.1002/ana.22321y FULLTEXT
8564 u https://europepmc.org/articles/pmc3082599?pdf=render
8564 8u https://lup.lub.lu.se/record/1988126
8564 8u https://doi.org/10.1002/ana.22321
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:122501356

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