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Search: (WFRF:(Ahlbom Anders)) srt2:(2005-2009) pers:(Swerdlow Anthony) > The Common D302H Va...

The Common D302H Variant of CASP8 Is Associated with Risk of Glioma

Bethke, Lara (author)
Sullivan, Kate (author)
Webb, Emily (author)
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Murray, Anne (author)
Schoemaker, Minouk (author)
Auvinen, Anssi (author)
Karolinska Institutet
Kiuru, Anne (author)
Salminen, Tiina (author)
Johansen, Christoffer (author)
Collatz Christensen, Helle (author)
Muir, Kenneth (author)
McKinney, Patricia (author)
Hepworth, Sarah (author)
Dimitropoulou, Polyxeni (author)
Lophatananon, Artitaya (author)
Feychting, Maria (author)
Karolinska Institutet
Lönn, Stefan (author)
Karolinska Institutet
Ahlbom, Anders (author)
Malmer, Beatrice (author)
Umeå universitet,Onkologi
Henriksson, Roger (author)
Umeå universitet,Onkologi
Swerdlow, Anthony (author)
Houlston, Richard (author)
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 (creator_code:org_t)
American Association for Cancer Research (AACR), 2008
2008
English.
In: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 17:4, s. 987-989
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and, hence, a defense against cancer. We tested the hypothesis that the CASP8 polymorphism D302H influences risk of glioma through analysis of five series of glioma case patients and controls (n = 1,005 and 1,011, respectively). Carrier status for the rare allele of D302H was associated with a 1.37-fold increased risk (95% confidence interval, 1.10-1.70; P = 0.004). The association of CASP8 D302H with glioma risk indicates the importance of inherited variation in the apoptosis pathway in susceptibility to this form of primary brain tumor.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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