Search: (WFRF:(Allen Naomi E.)) pers:(Trichopoulou Antonia) >
Hemochromatosis (HF...
Hemochromatosis (HFE) gene mutations and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
-
Agudo, Antonio (author)
-
Bonet, Catalina (author)
-
Sala, Núria (author)
-
show more...
-
Muñoz, Xavier (author)
-
Aranda, Núria (author)
-
Fonseca-Nunes, Ana (author)
-
Clavel-Chapelon, Françoise (author)
-
Boutron-Ruault, Marie Christine (author)
-
Vineis, Paolo (author)
-
Panico, Salvatore (author)
-
Palli, Domenico (author)
-
Tumino, Rosario (author)
-
Grioni, Sara (author)
-
Quirós, J Ramón (author)
-
Molina, Esther (author)
-
Navarro, Carmen (author)
-
Barricarte, Aurelio (author)
-
Chamosa, Saioa (author)
-
Allen, Naomi E (author)
-
Khaw, Kay-Tee (author)
-
Bueno-de-Mesquita, H Bas (author)
-
Siersema, Peter D (author)
-
Numans, Mattijs E (author)
-
Trichopoulou, Antonia (author)
-
Lagiou, Pagona (author)
-
Trichopoulos, Dimitrios (author)
-
Kaaks, Rudof (author)
-
Canzian, Federico (author)
-
Boeing, Heiner (author)
-
Meidtner, Karina (author)
-
- Johansson, Mattias (author)
- Umeå universitet,Medicinska fakulteten,WHO, IARC, Lyon, France
-
- Sund, Malin, 1972- (author)
- Umeå universitet,Kirurgi
-
- Manjer, Jonas (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
-
Overvad, Kim (author)
-
Tjonneland, Anne (author)
-
Lund, Eiliv (author)
-
- Weiderpass, Elisabete (author)
- Karolinska Institutet
-
Jenab, Mazda (author)
-
Fedirko, Veronika (author)
-
Offerhaus, G Johan A (author)
-
Riboli, Elio (author)
-
González, Carlos A (author)
-
Jakszyn, Paula (author)
-
show less...
-
(creator_code:org_t)
- 2013-02-06
- 2013
- English.
-
In: Carcinogenesis. - : Oxford University Press. - 0143-3334 .- 1460-2180. ; 34:6, s. 1244-1250
- Related links:
-
https://academic.oup...
-
show more...
-
http://dx.doi.org/10...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Hereditary hemochromatosis (HH) is a strong risk factor for hepatocellular cancer, and mutations in the HFE gene associated with HH and iron overload may be related to other tumors, but no studies have been reported for gastric cancer (GC). A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), including 365 incident gastric adenocarcinoma and 1284 controls matched by center, sex, age and date of blood collection. Genotype analysis was performed for two functional polymorphisms (C282Y/rs1800562 and H63D/rs1799945) and seven tagSNPs of the HFE genomic region. Association with all gastric adenocarcinoma, and according to anatomical localization and histological subtype, was assessed by means of the odds ratio (OR) and 95% confidence interval (CI) estimated by unconditional logistic regression adjusted for the matching variables. We observed a significant association for H63D with OR (per rare allele) of 1.32 (CI = 1.03-1.69). In subgroup analyses, the association was stronger for non-cardia anatomical subsite (OR = 1.60, CI = 1.16-2.21) and intestinal histological subtype (OR = 1.82, CI = 1.27-2.62). Among intestinal cases, two tagSNPs (rs1572982 and rs6918586) also showed a significant association that disappeared after adjustment for H63D. No association with tumors located in the cardia or with diffuse subtype was found for any of the nine SNPs analyzed. Our results suggest that H63D variant in HFE gene seems to be associated with GC risk of the non-cardia region and intestinal type, possibly due to its association with iron overload although a role for other mechanisms cannot be entirely ruled out.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Agudo, Antonio
-
Bonet, Catalina
-
Sala, Núria
-
Muñoz, Xavier
-
Aranda, Núria
-
Fonseca-Nunes, A ...
-
show more...
-
Clavel-Chapelon, ...
-
Boutron-Ruault, ...
-
Vineis, Paolo
-
Panico, Salvator ...
-
Palli, Domenico
-
Tumino, Rosario
-
Grioni, Sara
-
Quirós, J Ramón
-
Molina, Esther
-
Navarro, Carmen
-
Barricarte, Aure ...
-
Chamosa, Saioa
-
Allen, Naomi E
-
Khaw, Kay-Tee
-
Bueno-de-Mesquit ...
-
Siersema, Peter ...
-
Numans, Mattijs ...
-
Trichopoulou, An ...
-
Lagiou, Pagona
-
Trichopoulos, Di ...
-
Kaaks, Rudof
-
Canzian, Federic ...
-
Boeing, Heiner
-
Meidtner, Karina
-
Johansson, Matti ...
-
Sund, Malin, 197 ...
-
Manjer, Jonas
-
Overvad, Kim
-
Tjonneland, Anne
-
Lund, Eiliv
-
Weiderpass, Elis ...
-
Jenab, Mazda
-
Fedirko, Veronik ...
-
Offerhaus, G Joh ...
-
Riboli, Elio
-
González, Carlos ...
-
Jakszyn, Paula
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Surgery
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Health Care Serv ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Nutrition and Di ...
- Articles in the publication
-
Carcinogenesis
- By the university
-
Umeå University
-
Lund University
-
Karolinska Institutet