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Impact of in vivo T...
Impact of in vivo T-cell depletion on outcome of AML patients in first CR given peripheral blood stem cells and reduced-intensity conditioning allo-SCT from a HLA-identical sibling donor : a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation
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- Baron, F. (författare)
- University of Liege, Belgium
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- Labopin, M. (författare)
- Hospital Saint Antoine / Pierre-and-Marie-Curie University, Paris, France
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- Blaise, D. (författare)
- CHU Marseille, France
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- Lopez-Corral, L. (författare)
- Hospital Clinico Universitario, Salamanca, Spain
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- Vigouroux, S. (författare)
- CHU Bordeaux, France
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- Craddock, C. (författare)
- Queen Elizabeth Hospital and School of Cancer Studies, University of Birmingham, UK
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- Attal, M. (författare)
- CHU Toulouse, France
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- Jindra, P. (författare)
- Charles University Medical School and Teaching Hospital, Pilsen, Czech Republic
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- Goker, H. (författare)
- Hacettepe University, Ankara,Turkey
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- Socie, G. (författare)
- Saint-Louis Hospital, Paris, France
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- Chevallier, P. (författare)
- CHU Nantes, France
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- Browne, P. (författare)
- St James Hospital, Dublin, Ireland
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- Sandstedt, A. (författare)
- Östergötlands Läns Landsting,Hematologiska kliniken US
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- Duarte, R. F. (författare)
- Hospital Llobregat, Barcelona, Spain
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- Nagler, A. (författare)
- Tel Aviv University, Israel
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- Mohty, M. (författare)
- Hospital Saint Antoine / Pierre-and-Marie-Curie University, Paris, France
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(creator_code:org_t)
- 2014-01-13
- 2014
- Engelska.
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Ingår i: Bone Marrow Transplantation. - : Nature Publishing Group. - 0268-3369 .- 1476-5365. ; 49:3, s. 389-396
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The impact of in vivo T-cell depletion on transplantation outcomes in patients transplanted with reduced-intensity conditioning (RIC) remains controversial. This study assessed the outcome of 1250 adult patients with de novo AML in first CR (CR1) given PBSC from HLA-identical siblings after chemotherapy-based RIC. A total of 554 patients did not receive any form of in vivo T-cell depletion (control group), whereas antithymocyte globulin (ATG) and alemtuzumab were given in 444 and 252 patients, respectively. The incidences of grade II-IV acute GVHD were 21.4, 17.6 and 10.2% in control, ATG and alemtuzumab patients, respectively (P less than 0.001). In multivariate analysis, the use of ATG and the use of alemtuzumab were each associated with a lower risk of chronic GVHD (P less than 0.001 each), but a similar risk of relapse, and of nonrelapse mortality, and similar leukemia-free survival and OS. Further, among patients given BU-based RIC, the use of less than 6 mg/kg ATG did not increase the risk of relapse (hazard ratio, HR=1.1), whereas there was a suggestion for higher relapse risk in patients given greater than= 6 mg/kg ATG (HR=1.4, P=0.08). In summary, these data suggest that a certain amount of in vivo T-Cell depletion can be safely used in the conditioning of AML patients in CR1 given PBSC after chemotherapy-based RIC.
Nyckelord
- reduced-intensity conditioning; AML; GVHD; ATG; alemtuzumab
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Baron, F.
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Labopin, M.
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Blaise, D.
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Lopez-Corral, L.
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Vigouroux, S.
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Craddock, C.
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visa fler...
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Attal, M.
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Jindra, P.
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Goker, H.
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Socie, G.
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Chevallier, P.
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Browne, P.
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Sandstedt, A.
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Duarte, R. F.
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Nagler, A.
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Mohty, M.
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