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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 09525naa a2202353 4500 | |
| 001 | oai:gup.ub.gu.se/255156 | |
| 003 | SwePub | |
| 008 | 240528s2017 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-137630 | |
| 009 | oai:prod.swepub.kib.ki.se:136047894 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2551562 URI |
| 024 | 7 | a https://doi.org/10.1038/tp.2017.1152 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1376302 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1360478942 URI |
| 040 | a (SwePub)gud (SwePub)umud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Witt, S. H.4 aut |
| 245 | 1 0 | a Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia |
| 264 | c 2017-06-20 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2017 |
| 520 | a Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case-control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes: DPYD (P = 4.42 x 10(-7)) and PKP4 (P = 8.67 x 10(-7)); and gene-set analysis yielded a significant finding for exocytosis (GO: 0006887, PFDR = 0.019; FDR, false discovery rate). Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (r(g) = 0.28 [P = 2.99 x 10(-3)]), SCZ (r(g) = 0.34 [P = 4.37 x 10(-5)]) and MDD (r(g) = 0.57 [P = 1.04 x 10(-3)]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 653 | a METAANALYSIS | |
| 653 | a TRAITS | |
| 653 | a FAMILY | |
| 653 | a RISK | |
| 653 | a SET | |
| 653 | a PSYCHOPATHOLOGY | |
| 653 | a COMORBIDITY | |
| 653 | a PATTERNS | |
| 653 | a FEATURES | |
| 653 | a TWIN | |
| 700 | 1 | a Streit, F.4 aut |
| 700 | 1 | a Jungkunz, M.4 aut |
| 700 | 1 | a Frank, J.4 aut |
| 700 | 1 | a Awasthi, S.4 aut |
| 700 | 1 | a Reinbold, C. S.4 aut |
| 700 | 1 | a Treutlein, J.4 aut |
| 700 | 1 | a Degenhardt, F.4 aut |
| 700 | 1 | a Forstner, A. J.u Karolinska Institutet4 aut |
| 700 | 1 | a Heilmann-Heimbach, S.4 aut |
| 700 | 1 | a Dietl, L.4 aut |
| 700 | 1 | a Schwarze, C. E.4 aut |
| 700 | 1 | a Schendel, D.4 aut |
| 700 | 1 | a Strohmaier, J.4 aut |
| 700 | 1 | a Abdellaoui, A.4 aut |
| 700 | 1 | a Adolfsson, Rolfu Umeå universitet,Psykiatri4 aut0 (Swepub:umu)road0001 |
| 700 | 1 | a Air, T. M.4 aut |
| 700 | 1 | a Akil, H.4 aut |
| 700 | 1 | a Alda, M.4 aut |
| 700 | 1 | a Alliey-Rodriguez, N.4 aut |
| 700 | 1 | a Andreassen, O. A.4 aut |
| 700 | 1 | a Babadjanova, G.4 aut |
| 700 | 1 | a Bass, N. J.4 aut |
| 700 | 1 | a Bauer, M.4 aut |
| 700 | 1 | a Baune, B. T.4 aut |
| 700 | 1 | a Bellivier, F.4 aut |
| 700 | 1 | a Bergen, S.u Karolinska Institutet4 aut |
| 700 | 1 | a Bethell, A.4 aut |
| 700 | 1 | a Biernacka, J. M.4 aut |
| 700 | 1 | a Blackwood, D. H. R.4 aut |
| 700 | 1 | a Boks, M. P.4 aut |
| 700 | 1 | a Boomsma, D. I.4 aut |
| 700 | 1 | a Borglum, A. D.4 aut |
| 700 | 1 | a Borrmann-Hassenbach, M.4 aut |
| 700 | 1 | a Brennan, P.4 aut |
| 700 | 1 | a Budde, M.4 aut |
| 700 | 1 | a Buttenschon, H. N.4 aut |
| 700 | 1 | a Byrne, E. M.4 aut |
| 700 | 1 | a Cervantes, P.4 aut |
| 700 | 1 | a Clarke, T. K.4 aut |
| 700 | 1 | a Craddock, N.4 aut |
| 700 | 1 | a Cruceanu, C.4 aut |
| 700 | 1 | a Curtis, D.4 aut |
| 700 | 1 | a Czerski, P. M.4 aut |
| 700 | 1 | a Dannlowski, U.4 aut |
| 700 | 1 | a Davis, T.4 aut |
| 700 | 1 | a de Geus, E. J. C.4 aut |
| 700 | 1 | a Di Florio, A.4 aut |
| 700 | 1 | a Djurovic, S.4 aut |
| 700 | 1 | a Domenici, E.4 aut |
| 700 | 1 | a Edenberg, H. J.4 aut |
| 700 | 1 | a Etain, B.4 aut |
| 700 | 1 | a Fischer, S. B.4 aut |
| 700 | 1 | a Forty, L.4 aut |
| 700 | 1 | a Fraser, C.4 aut |
| 700 | 1 | a Frye, M. A.4 aut |
| 700 | 1 | a Fullerton, J. M.4 aut |
| 700 | 1 | a Gade, K.4 aut |
| 700 | 1 | a Gershon, E. S.4 aut |
| 700 | 1 | a Giegling, I.4 aut |
| 700 | 1 | a Gordon, S. D.4 aut |
| 700 | 1 | a Gordon-Smith, K.4 aut |
| 700 | 1 | a Grabe, H. J.4 aut |
| 700 | 1 | a Green, E. K.4 aut |
| 700 | 1 | a Greenwood, T. A.4 aut |
| 700 | 1 | a Grigoroiu-Serbanescu, M.4 aut |
| 700 | 1 | a Guzman-Parra, J.4 aut |
| 700 | 1 | a Hall, L. S.4 aut |
| 700 | 1 | a Hamshere, M.4 aut |
| 700 | 1 | a Hauser, J.4 aut |
| 700 | 1 | a Hautzinger, M.4 aut |
| 700 | 1 | a Heilbronner, U.4 aut |
| 700 | 1 | a Herms, S.4 aut |
| 700 | 1 | a Hitturlingappa, S.4 aut |
| 700 | 1 | a Hoffmann, P.4 aut |
| 700 | 1 | a Holmans, P.4 aut |
| 700 | 1 | a Hottenga, J. J.4 aut |
| 700 | 1 | a Jamain, S.4 aut |
| 700 | 1 | a Jones, I.4 aut |
| 700 | 1 | a Jones, L. A.4 aut |
| 700 | 1 | a Jureus, A.4 aut |
| 700 | 1 | a Kahn, R. S.4 aut |
| 700 | 1 | a Kammerer-Ciernioch, J.4 aut |
| 700 | 1 | a Kirov, G.4 aut |
| 700 | 1 | a Kittel-Schneider, S.4 aut |
| 700 | 1 | a Kloiber, S.4 aut |
| 700 | 1 | a Knott, S. V.4 aut |
| 700 | 1 | a Kogevinas, M.4 aut |
| 700 | 1 | a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xlandt |
| 700 | 1 | a Leber, M.4 aut |
| 700 | 1 | a Leboyer, M.4 aut |
| 700 | 1 | a Li, Q. S.4 aut |
| 700 | 1 | a Lissowska, J.4 aut |
| 700 | 1 | a Lucae, S.4 aut |
| 700 | 1 | a Martin, N. G.4 aut |
| 700 | 1 | a Mayoral-Cleries, F.4 aut |
| 700 | 1 | a McElroy, S. L.4 aut |
| 700 | 1 | a McIntosh, A. M.4 aut |
| 700 | 1 | a McKay, J. D.4 aut |
| 700 | 1 | a McQuillin, A.4 aut |
| 700 | 1 | a Medland, S. E.4 aut |
| 700 | 1 | a Middeldorp, C. M.4 aut |
| 700 | 1 | a Milaneschi, Y.4 aut |
| 700 | 1 | a Mitchell, P. B.4 aut |
| 700 | 1 | a Montgomery, G. W.4 aut |
| 700 | 1 | a Morken, G.4 aut |
| 700 | 1 | a Mors, O.4 aut |
| 700 | 1 | a Muhleisen, T.4 aut |
| 700 | 1 | a Muller-Myhsok, B.4 aut |
| 700 | 1 | a Myers, R. M.4 aut |
| 700 | 1 | a Nievergelt, C. M.4 aut |
| 700 | 1 | a Nurnberger, J. I.4 aut |
| 700 | 1 | a O'Donovan, M. C.4 aut |
| 700 | 1 | a Loohuis, L. M. O.4 aut |
| 700 | 1 | a Ophoff, R.4 aut |
| 700 | 1 | a Oruc, L.4 aut |
| 700 | 1 | a Owen, M. J.4 aut |
| 700 | 1 | a Paciga, S. A.4 aut |
| 700 | 1 | a Penninx, Bwjh4 aut |
| 700 | 1 | a Perry, A.4 aut |
| 700 | 1 | a Pfennig, A.4 aut |
| 700 | 1 | a Potash, J. B.4 aut |
| 700 | 1 | a Preisig, M.4 aut |
| 700 | 1 | a Reif, A.4 aut |
| 700 | 1 | a Rivas, F.4 aut |
| 700 | 1 | a Rouleau, G. A.4 aut |
| 700 | 1 | a Schofield, P. R.4 aut |
| 700 | 1 | a Schulze, T. G.4 aut |
| 700 | 1 | a Schwarz, M.4 aut |
| 700 | 1 | a Scott, L.4 aut |
| 700 | 1 | a Sinnamon, G. C. B.4 aut |
| 700 | 1 | a Stahl, E. A.4 aut |
| 700 | 1 | a Strauss, J.4 aut |
| 700 | 1 | a Turecki, G.4 aut |
| 700 | 1 | a Van der Auwera, S.4 aut |
| 700 | 1 | a Vedder, H.4 aut |
| 700 | 1 | a Vincent, J. B.4 aut |
| 700 | 1 | a Willemsen, G.4 aut |
| 700 | 1 | a Witt, C. C.4 aut |
| 700 | 1 | a Wray, N. R.4 aut |
| 700 | 1 | a Xi, H. S.4 aut |
| 700 | 1 | a Tadic, A.4 aut |
| 700 | 1 | a Dahmen, N.4 aut |
| 700 | 1 | a Schott, B. H.4 aut |
| 700 | 1 | a Cichon, S.4 aut |
| 700 | 1 | a Nothen, M. M.4 aut |
| 700 | 1 | a Ripke, S.4 aut |
| 700 | 1 | a Mobascher, A.4 aut |
| 700 | 1 | a Rujescu, D.4 aut |
| 700 | 1 | a Lieb, K.4 aut |
| 700 | 1 | a Roepke, S.4 aut |
| 700 | 1 | a Schmahl, C.4 aut |
| 700 | 1 | a Bohus, M.4 aut |
| 700 | 1 | a Rietschel, M.4 aut |
| 700 | 1 | a Psychiat Genomics, Consortium4 aut |
| 710 | 2 | a Karolinska Institutetb Psykiatri4 org |
| 773 | 0 | t Translational Psychiatryd : Springer Science and Business Media LLCg 7q 7x 2158-3188 |
| 856 | 4 | u https://www.nature.com/articles/tp2017115.pdf |
| 856 | 4 | u https://doi.org/10.1038/tp.2017.115y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1127762/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/255156 |
| 856 | 4 8 | u https://doi.org/10.1038/tp.2017.115 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-137630 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:136047894 |
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