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Sökning: (WFRF:(Benitez Javier)) pers:(Hopper John L.) pers:(Le Marchand Loic) pers:(Flyger Henrik) > Aggregation tests i...

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FältnamnIndikatorerMetadata
00035433naa a2203349 4500
001oai:DiVA.org:uu-498948
003SwePub
008230322s2023 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:152000895
009oai:lup.lub.lu.se:03b290d6-d650-490a-9e52-2fcb867a25b3
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4989482 URI
024a https://doi.org/10.1186/s13073-022-01152-52 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1520008952 URI
024a https://lup.lub.lu.se/record/03b290d6-d650-490a-9e52-2fcb867a25b32 URI
040 a (SwePub)uud (SwePub)kid (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Mueller, Stefanie H.u UCL, Inst Hlth Informat, London, England.,University College London4 aut
2451 0a Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry
264 c 2023-01-26
264 1b BioMed Central (BMC),c 2023
338 a electronic2 rdacarrier
520 a Background: Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.Methods: We evaluated the potential of gene-based aggregation in the Breast Cancer Association Consortium cohorts including 83,471 cases and 59,199 controls. Low-frequency variants were aggregated for individual genes' coding and regulatory regions. Association results in European ancestry samples were compared to single-marker association results in the same cohort. Gene-based associations were also combined in meta-analysis across individuals with European, Asian, African, and Latin American and Hispanic ancestry.Results: In European ancestry samples, 14 genes were significantly associated (q < 0.05) with BC. Of those, two genes, FMNL3 (P = 6.11 x 10(-6)) and AC058822.1 (P = 1.47 x 10(-4)), represent new associations. High FMNL3 expression has previously been linked to poor prognosis in several other cancers. Meta-analysis of samples with diverse ancestry discovered further associations including established candidate genes ESR1 and CBLB. Furthermore, literature review and database query found further support for a biologically plausible link with cancer for genes CBLB, FMNL3, FGFR2, LSP1, MAP3K1, and SRGAP2C.Conclusions: Using extended gene-based aggregation tests including coding and regulatory variation, we report identification of plausible target genes for previously identified single-marker associations with BC as well as the discovery of novel genes implicated in BC development. Including multi ancestral cohorts in this study enabled the identification of otherwise missed disease associations as ESR1 (P = 1.31 x 10(-5)), demonstrating the importance of diversifying study cohorts.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Breast cancer susceptibility
653 a Diverse ancestry
653 a Rare variants
653 a Gene regulation
653 a Genome-wide association study
653 a Breast cancer susceptibility
653 a Diverse ancestry
653 a Gene regulation
653 a Genome-wide association study
653 a Rare variants
653 a African
653 a ancestry group
653 a Article
653 a Asian
653 a boredom susceptibility
653 a breast cancer
653 a cancer prognosis
653 a CBLB gene
653 a cohort analysis
653 a controlled study
653 a ESR1 gene
653 a European
653 a FGFR2 gene
653 a FMNL3 gene
653 a gene base aggregation
653 a gene expression level
653 a gene structure
653 a genetic association
653 a genetic association study
653 a genetic code
653 a genetic variability
653 a Hispanic
653 a human
653 a human cell
653 a human tissue
653 a LSP1 gene
653 a major clinical study
653 a MAP3K1 gene
653 a meta analysis (topic)
653 a South and Central America
653 a SRGAP2C gene
653 a statistical significance
653 a tumor-related gene
653 a Black person
653 a breast tumor
653 a female
653 a genetic predisposition
653 a genetic screening
653 a genetics
653 a genome-wide association study
653 a meta analysis
653 a procedures
653 a single nucleotide polymorphism
653 a FMNL3 protein, human
653 a methenamine
653 a Black People
653 a Breast Neoplasms
653 a Female
653 a Formins
653 a Genetic Predisposition to Disease
653 a Genetic Testing
653 a Genome-Wide Association Study
653 a Humans
653 a Polymorphism, Single Nucleotide
700a Lai, Alvina G.u UCL, Inst Hlth Informat, London, England.4 aut
700a Valkovskaya, Mariau UCL, Div Psychiat, London, England.4 aut
700a Michailidou, Kyriakiu Cyprus Inst Neurol & Genet, Biostat Unit, CY-2371 Nicosia, Cyprus.;Cyprus Inst Neurol & Genet, Cyprus Sch Mol Med, CY-2371 Nicosia, Cyprus.;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.4 aut
700a Bolla, Manjeet K.u Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.4 aut
700a Wang, Qinu Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.4 aut
700a Dennis, Joeu Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.4 aut
700a Lush, Michaelu Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.4 aut
700a Abu-Ful, Zomorudau Carmel Hosp, Clalit Natl Canc Control Ctr, IL-35254 Haifa, Israel.;Technion Fac Med, IL-35254 Haifa, Israel.4 aut
700a Ahearn, Thomas U.u NCI, Div Canc Epidemiol & Genet, US Dept HHS, NIH, Bethesda, MD 20850 USA.4 aut
700a Andrulis, Irene L.u Lunenfeld Tanenbaum Res Inst Mt Sinai Hosp, Fred A Litwin Ctr Canc Genet, Toronto, ON M5G 1X5, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A8, Canada.4 aut
700a Anton-Culver, Hodau Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Med, Irvine, CA 92617 USA.4 aut
700a Antonenkova, Natalia N.u NN Alexandrov Res Inst Oncol & Med Radiol, Minsk 223040, BELARUS.4 aut
700a Arndt, Volkeru German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany.4 aut
700a Aronson, Kristan J.u Queens Univ, Canc Res Inst, Dept Publ Hlth Sci, Kingston, ON K7L 3N6, Canada.4 aut
700a Augustinsson, A.u Lund University,Lunds universitet,Karolinska Institutet,Vård i högteknologisk miljö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Cancerepidemiologi & strål,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Care in high technological environments,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Cancerepidemiology and radiation,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-aea
700a Baert, Thaisu Univ Hosp Leuven, Leuven Multidisciplinary Breast Ctr, Leuven Canc Inst, Dept Oncol, B-3000 Louvain, Belgium.4 aut
700a Freeman, Laura E. Beaneu NCI, Div Canc Epidemiol & Genet, US Dept HHS, NIH, Bethesda, MD 20850 USA.4 aut
700a Beckmann, Matthias W.u Friedrich Alexander Univ Erlangen Nuremberg FAU, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Dept Gynecol & Obstet, D-91054 Erlangen, Germany.4 aut
700a Behrens, Sabineu German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany.4 aut
700a Benitez, Javieru Biomed Network Rare Dis CIBERER, Madrid 28029, Spain.;Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Programme, Madrid 28029, Spain.4 aut
700a Bermisheva, Marinau Russian Acad Sci, Inst Biochem & Genet, Ufa Fed Res Ctr, Ufa 450054, Russia.4 aut
700a Blomqvist, Carlu Univ Helsinki, Helsinki Univ Hosp, Dept Oncol, Helsinki 00290, Finland.;Örebro Univ Hosp, Dept Oncol, S-70185 Örebro, Sweden.4 aut
700a Bogdanova, Natalia, Vu NN Alexandrov Res Inst Oncol & Med Radiol, Minsk 223040, BELARUS.;Hannover Med Sch, Depart Ment Radiat Oncol, D-30625 Hannover, Germany.;Hannover Med Sch, Gynaecol Res Unit, D-30625 Hannover, Germany.4 aut
700a Bojesen, Stig E.u Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, DK-2730 Herlev, Denmark.;Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, DK-2730 Herlev, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, DK-2200 Copenhagen, Denmark.4 aut
700a Bonanni, Bernardou European Inst Oncol IRCCS, Div Canc Prevent & Genet, IEO, I-20141 Milan, Italy.,University College London4 aut
700a Brenner, Hermannu German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany.;German Canc Res Ctr, Natl Ctr Tumor Dis NCT, Div Prevent Oncol, D-69120 Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, D-69120 Heidelberg, Germany.4 aut
700a Brucker, Sara Y.u Univ Tubingen, Dept Gynecol & Obstet, D-72076 Tubingen, Germany.4 aut
700a Buys, Saundra S.u Huntsman Canc Inst, Dept Med, Salt Lake City, UT 84112 USA.4 aut
700a Castelao, Jose E.u Inst Invest Sanitaria Galicia Sur IISGS, Oncol & Genet Unit, Xerencia Xest Integrada Vigo SERGAS, Vigo 36312, Spain.4 aut
700a Chan, Tsun L.u Hong Kong Hereditary Breast Canc Family Registry, Hong Kong, Peoples R China.;Hong Kong Sanat & Hosp, Dept Mol Pathol, Hong Kong, Peoples R China.4 aut
700a Chang-Claude, Jennyu German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany.;Univ Canc Ctr Hamburg UCCH, Univ Med Ctr Hamburg Eppendorf, Canc Epidemiol Grp, D-20246 Hamburg, Germany.4 aut
700a Chanock, Stephen J.u NCI, Div Canc Epidemiol & Genet, US Dept HHS, NIH, Bethesda, MD 20850 USA.4 aut
700a Choi, Ji-Yeobu Seoul Natl Univ, Dept Biomed Sci, Grad Sch, Seoul 03080, South Korea.;Seoul Natl Univ, Canc Res Inst, Seoul 03080, South Korea.;Seoul Natl Univ, Inst Hlth Policy & Management, Med Res Ctr, Seoul 03080, South Korea.4 aut
700a Chung, Wendy K.u Karolinska Institutet4 aut
700a Colonna, Sarah, Vu Huntsman Canc Inst, Dept Med, Salt Lake City, UT 84112 USA.4 aut
700a Cornelissen, Stenu Netherlands Canc Inst, Div Mol Pathol, Antoni Van Leeuwenhoek Hosp, NL-1066 CX Amsterdam, Netherlands.4 aut
700a Couch, Fergus J.u Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA.4 aut
700a Czene, Kamilau Karolinska Institutet4 aut
700a Daly, Mary B.u Fox Chase Canc Ctr, Dept Clin Genet, Philadelphia, PA 19111 USA.4 aut
700a Devilee, Peteru Leiden Univ Med Ctr, Dept Pathol, NL-2333 ZA Leiden, Netherlands.;Leiden Univ Med Ctr, Dept Human Genet, NL-2333 ZA Leiden, Netherlands.4 aut
700a Dork, Thilou Hannover Med Sch, Gynaecol Res Unit, D-30625 Hannover, Germany.4 aut
700a Dossus, Laureu Int Agcy Res Canc IARC WHO, Nutr & Metab Sect, F-69372 Lyon, France.4 aut
700a Dwek, Miriamu Univ Westminster, Sch Life Sci, London W1W 6UW, England.4 aut
700a Eccles, Diana M.u Univ Southampton, Fac Med, Southampton SO17 1BJ, Hants, England.4 aut
700a Ekici, Arif B.u Friedrich Alexander Univ Erlangen Nuremberg FAU, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Inst Human Genet, D-91054 Erlangen, Germany.4 aut
700a Eliassen, A. Heatheru Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.4 aut
700a Engel, Christophu Univ Leipzig, Inst Med Informat Stat & Epidemiol, D-04107 Leipzig, Germany.;Univ Leipzig, LIFE Leipzig Res Ctr Civilizat Dis, D-04103 Leipzig, Germany.4 aut
700a Evans, D. Garethu Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol, Sch Biol Sci, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, North West Genom Lab Hub,St Marys Hosp, Manchester, Lancs, England.4 aut
700a Fasching, Peter A.u Friedrich Alexander Univ Erlangen Nuremberg FAU, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Dept Gynecol & Obstet, D-91054 Erlangen, Germany.;Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Hematol & Oncol, Los Angeles, CA 90095 USA.4 aut
700a Fletcher, Oliviau Breast Canc Now Toby Robins Res Ctr, Inst Canc Res, London SW7 3RP, England.4 aut
700a Flyger, Henriku Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Breast Surg, DK-2730 Herlev, Denmark.4 aut
700a Gago-Dominguez, Manuelau Complejo Hosp Univ Santiago, Inst Invest Sanitaria Santiago Compostela IDIS, SERGAS, Fdn Poebl Galega Med Xenom, Santiago De Compostela 15706, Spain.;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92037 USA.4 aut
700a Gao, Yu-Tangu Shanghai Canc Inst, Dept Epidemiol, Shanghai 20032, Peoples R China.4 aut
700a Garcia-Closas, Montserratu NCI, Div Canc Epidemiol & Genet, US Dept HHS, NIH, Bethesda, MD 20850 USA.4 aut
700a Garcia-Saenz, Jose A.u Hosp Clin San Carlos, Ctr Invest Biomed Red Canc CIBERONC, Inst Invest Sanitaria San Carlos IdISSC, Med Oncol Dept, Madrid 28040, Spain.4 aut
700a Genkinger, Jeanineu Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA.4 aut
700a Gentry-Maharaj, Aleksandrau UCL, Inst Clin Trials & Methodol, London WC1V 6LJ, England.4 aut
700a Grassmann, Felixu Karolinska Inst, Dept Med Epidemiol & Biostat, S-17165 Stockholm, Sweden.;Hlth & Med Univ, D-14471 Potsdam, Germany.4 aut
700a Guenel, Pascalu Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP, INSERM, Team Exposome & Hered, F-94805 Villejuif, France.4 aut
700a Gundert, Melanieu German Canc Res Ctr, Mol Epidemiol Grp, C08069120, Heidelberg, Germany.;Heidelberg Univ, Univ Womens Clin Heidelberg, Mol Biol Breast Canc, D-69120 Heidelberg, Germany.;Helmholtz Zentrum Munchen, Inst Diabet Res, German Res Ctr Environm Hlth, D-85764 Neuherberg, Germany.4 aut
700a Haeberle, Lotharu Friedrich Alexander Univ Erlangen Nuremberg FAU, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Dept Gynecol & Obstet, D-91054 Erlangen, Germany.4 aut
700a Hahnen, Ericu Univ Cologne, Univ Hosp Cologne, Fac Med, Ctr Familial Breast & Ovarian Canc, D-50937 Cologne, Germany.;Univ Cologne, Univ Hosp Cologne, Fac Med, Ctr Integrated Oncol CIO, D-50937 Cologne, Germany.4 aut
700a Haiman, Christopher A.u Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.4 aut
700a Hakansson, Niclasu Karolinska Institutet4 aut
700a Hall, Peru Karolinska Institutet4 aut
700a Harkness, Elaine F.u Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol, Div Informat, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, Wythenshawe Hosp, Nightingale & Genesis Prevent Ctr, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, NIHR Manchester Biomed Res Unit, Manchester, Lancs, England.4 aut
700a Harrington, Patricia A.u Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.4 aut
700a Hartikainen, Jaana M.u Univ Eastern Finland, Translat Canc Res Area, Kuopio 70210, Finland.;Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, Kuopio 70210, Finland.4 aut
700a Hartman, Mikaelu Natl Univ Singapore, Natl Univ Hlth Syst, Saw Swee Hock Sch Publ Hlth, Singapore 119077, Singapore.;Natl Univ Hlth Syst, Dept Surg, Singapore 119228, Singapore.4 aut
700a Hein, Alexanderu Friedrich Alexander Univ Erlangen Nuremberg FAU, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Dept Gynecol & Obstet, D-91054 Erlangen, Germany.4 aut
700a Ho, Weang-Keeu Univ Nottingham, Dept Math Sci, Fac Sci & Engn, Malaysia Campus, Semenyih 43500, Selangor, Malaysia.;Canc Res Malaysia, Breast Canc Res Programme, Subang Jaya 47500, Selangor, Malaysia.4 aut
700a Hooning, Maartje J.u Erasmus MC Canc Inst, Dept Med Oncol, NL-3015 GD Rotterdam, Netherlands.4 aut
700a Hoppe, Reineru Dr Margarete Fischer Bosch Inst Clin Pharmacol, D-70376 Stuttgart, Germany.;Univ Tubingen, D-72074 Tubingen, Germany.4 aut
700a Hopper, John L.u Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic 3010, Australia.4 aut
700a Houlston, Richard S.u Inst Canc Res, Div Genet & Epidemiol Ogy, London SM2 5NG, England.4 aut
700a Howell, Anthonyu Univ Manchester, Div Canc Sci, Manchester M13 9PL, Lancs, England.4 aut
700a Hunter, David J.u Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Univ Oxford, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England.4 aut
700a Huo, Dezhengu Univ Chicago, Ctr Clin Canc Genet, Chicago, IL 60637 USA.4 aut
700a Investigators, Abctbu Univ Sydney, Westmead Inst Med Res, Australian Breast Canc Tissue Bank, Sydney, NSW 2145, Australia.4 aut
700a Ito, Hidemiu Aichi Canc Ctr Res Inst, Div Canc Informat & Control, Nagoya, Aichi 4648681, Japan.;Nagoya Univ, Div Canc Epidemiol, Grad Sch Med, Nagoya, Aichi 4668550, Japan.4 aut
700a Iwasaki, Motokiu Natl Canc Ctr Inst Canc Control, Ctr Publ Hlth Sci, Div Epidemiol, Tokyo 1040045, Japan.4 aut
700a Jakubowska, Annau Pomeranian Med Univ, Dept Genet & Pathol, PL-71252 Szczecin, Poland.;Pomeranian Med Univ, Independent Lab Mol Biol & Genet Diagnost, PL-71252 Szczecin, Poland.4 aut
700a Janni, Wolfgangu Univ Hosp Ulm, Dept Gynaecol & Obstet, D-89075 Ulm, Germany.4 aut
700a John, Esther M.u Stanford Univ, Sch Med, Dept Epidemiol & Populat Hlth, Stanford, CA 94305 USA.;Stanford Univ, Sch Med, Stanford Canc Inst, Dept Med, Stanford, CA 94304 USA.4 aut
700a Jones, Michael E.u Inst Canc Res, Div Genet & Epidemiol Ogy, London SM2 5NG, England.4 aut
700a Jung, Audreyu German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany.4 aut
700a Kaaks, Rudolfu German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany.4 aut
700a Kang, Daeheeu Seoul Natl Univ, Canc Res Inst, Seoul 03080, South Korea.;Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul 03080, South Korea.4 aut
700a Khusnutdinova, Elza K.u Russian Acad Sci, Inst Biochem & Genet, Ufa Fed Res Ctr, Ufa 450054, Russia.;Bashkir State Univ, Dept Genet & Fundamental Med, Ufa 450000, Russia.4 aut
700a Kim, Sung-Wonu Daerim St Marys Hosp, Dept Surg, Seoul 07442, South Korea.4 aut
700a Kitahara, Cari M.u NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.4 aut
700a Koutros, Stellau NCI, Div Canc Epidemiol & Genet, US Dept HHS, NIH, Bethesda, MD 20850 USA.4 aut
700a Kraft, Peteru Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA.4 aut
700a Kristensen, Vessela N.u Univ Oslo, Fac Med, Inst Clin Med, N-0450 Oslo, Norway. Vestre Viken Hosp, Dept Res, N-3019 Drammen, Norway. Oslo Univ Hosp Ullev, Dept Canc, Div Surg, Sect Breast & Endocrine Surg, N-0450 Oslo, Norway. Oslo Univ Hosp, Dept Radiol & Nucl Med, N-0379 Oslo, Norway. Akershus Univ Hosp, Dept Pathol, N-1478 Lorenskog, Norway. Oslo Univ Hosp, Inst Canc Res, Dept Tumor Biol, N-0379 Oslo, Norway. Oslo Univ Hosp, Dept Oncol, Div Surg Canc & Transplantat Med, Radiumhosp, N-0379 Oslo, Norway. Oslo Univ Hosp, Natl Advisory Unit Late Effects Canc Treatment, N-0379 Oslo, Norway. Akershus Univ Hosp, Dept Oncol, N-1478 Lorenskog, Norway. Oslo Univ Hosp, Oslo Breast Canc Res Consortium, N-0379 Oslo, Norway.;Oslo Univ Hosp, Dept Med Genet, N-0379 Oslo, Norway.;Univ Oslo, N-0379 Oslo, Norway.4 aut
700a Kubelka-Sabit, Katerinau Clin Hosp Acibadem Sistina, Dept Histopathol & Cytol, Skopje 1000, North Macedonia.4 aut
700a Kurian, Allison W.u Stanford Univ, Sch Med, Dept Epidemiol & Populat Hlth, Stanford, CA 94305 USA.;Stanford Univ, Sch Med, Stanford Canc Inst, Dept Med, Stanford, CA 94304 USA.4 aut
700a Kwong, Avau Hong Kong Hereditary Breast Canc Family Registry, Hong Kong, Peoples R China.;Univ Hong Kong, Dept Surg, Hong Kong, Peoples R China.;Hong Kong Sanat & Hosp, Dept Surg, Hong Kong, Peoples R China.;Hong Kong Sanat & Hosp, Canc Genet Ctr, Hong Kong, Peoples R China.4 aut
700a Lacey, James, Vu City Hope Natl Med Ctr, Depart Ment Computat & Quantitat Med, Duarte, CA 91010 USA.;City Hope Natl Med Ctr, City Hope Comprehens Canc Ctr, Duarte, CA 91010 USA.4 aut
700a Lambrechts, Dietheru VIB Ctr Canc Biol, B-3001 Louvain, Belgium.;Univ Leuven, Dept Human Genet, Lab Translat Genet, B-3000 Louvain, Belgium.4 aut
700a Le Marchand, Loicu Univ Hawaii Canc Ctr, Epidemiol Program, Honolulu, HI 96813 USA.4 aut
700a Li, Jingmeiu Genome Inst Singapore, Human Genet Div, Singapore 138672, Singapore.4 aut
700a Linet, Marthau NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.4 aut
700a Lo, Wing-Yeeu Dr Margarete Fischer Bosch Inst Clin Pharmacol, D-70376 Stuttgart, Germany.;Univ Tubingen, D-72074 Tubingen, Germany.4 aut
700a Long, Jirongu Vanderbilt Univ, Vanderbilt Epidemiol Ctr, Vanderbilt Ingram Canc Ctr, Dept Med,Sch Med, Nashville, TN 37232 USA.4 aut
700a Lophatananon, Artitayau Univ Manchester, Fac Biol, Sch Hlth Sci, Div Populat Hlth Hlth Serv Res & Primary Care, Manchester M13 9PL, Lancs, England.4 aut
700a Mannermaa, Artou Univ Eastern Finland, Translat Canc Res Area, Kuopio 70210, Finland.;Univ Eastern Finland, Inst Clin Med Pathol & Forens Med, Kuopio 70210, Finland.;Kuopio Univ Hosp, Biobank Eastern Finland, Kuopio, Finland.4 aut
700a Manoochehri, Mehdiu German Canc Res Ctr, Mol Genet Breast Canc, D-69120 Heidelberg, Germany.4 aut
700a Margolin, Sarau Karolinska Institutet4 aut
700a Matsuo, Keitarou Nagoya Univ, Div Canc Epidemiol, Grad Sch Med, Nagoya, Aichi 4668550, Japan.;Aichi Canc Ctr Res Inst, Div Canc Epidemiol & Prevent, Nagoya, Aichi 4648681, Japan.4 aut
700a Mavroudis, Dimitriosu Univ Hosp Heraklion, Dept Med Oncol, Iraklion 71110, Greece.4 aut
700a Menon, Ushau UCL, Inst Clin Trials & Methodol, London WC1V 6LJ, England.4 aut
700a Muir, Kennethu Univ Manchester, Fac Biol, Sch Hlth Sci, Div Populat Hlth Hlth Serv Res & Primary Care, Manchester M13 9PL, Lancs, England.4 aut
700a Murphy, Rachel A.u Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC V6T 1Z4, Canada.;BC Canc, Canc Control Res, Vancouver, BC V5Z 1L3, Canada.4 aut
700a Nevanlinna, Heliu Univ Helsinki, Helsinki Univ Hosp, Dept Obstet & Gynecol, Helsinki 00290, Finland.4 aut
700a Newman, William G.u Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol, Sch Biol Sci, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, North West Genom Lab Hub,St Marys Hosp, Manchester, Lancs, England.4 aut
700a Niederacher, Dieteru Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Dept Gynecol & Obstet, D-40225 Dusseldorf, Germany.4 aut
700a O'Brien, Katie M.u NIEHS, Epidemiol Branch, NIH, Res Triangle Pk, NC 27709 USA.4 aut
700a Obi, Nadiau Univ Med Ctr Hamburg Eppendorf, Inst Med Biometry & Epidemiol, D-20246 Hamburg, Germany.4 aut
700a Offit, Kennethu Mem Sloan Kettering Canc Ctr, Dept Canc Biol & Genet, Clin Genet Res Lab, New York, NY 10065 USA.;Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, New York, NY 10065 USA.4 aut
700a Olopade, Olufunmilayo, Iu Univ Chicago, Ctr Clin Canc Genet, Chicago, IL 60637 USA.4 aut
700a Olshan, Andrew F.u Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.;Univ North Carolina Chapel Hill, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA.4 aut
700a Olsson, H.u Lund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Biomarkörer och Epi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Melanoma Study Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Biomarkers and epidemiology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-hol
700a Park, Sue K.u Seoul Natl Univ, Canc Res Inst, Seoul 03080, South Korea.;Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul 03080, South Korea.;Seoul Natl Univ, Coll Med, Integrated Major Innovat Med Sci, Seoul 03080, South Korea.4 aut
700a Patel, Alpa, Vu Amer Canc Soc, Dept Populat Sci, Atlanta, GA 30303 USA.4 aut
700a Patel, Achalu Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.;Univ North Carolina Chapel Hill, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA.4 aut
700a Perou, Charles M.u Univ North Carolina Chapel Hill, Dept Genet, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA.4 aut
700a Peto, Julianu London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England.4 aut
700a Pharoah, Paul D. P.u Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.4 aut
700a Plaseska-Karanfilska, Dijanau MASA, Res Ctr Genet Engn & Biotechnol Georgi D Efremov, Skopje 1000, North Macedonia.4 aut
700a Presneau, Nadegeu Univ Westminster, Sch Life Sci, London W1W 6UW, England.4 aut
700a Rack, Brigitteu Univ Hosp Ulm, Dept Gynaecol & Obstet, D-89075 Ulm, Germany.4 aut
700a Radice, Paolou Fdn IRCCS Ist Nazl Tumori INT, Dept Res, Unit Mol Bases Genet Risk & Genet Testing, I-20133 Milan, Italy.4 aut
700a Ramachandran, Dhanyau Hannover Med Sch, Gynaecol Res Unit, D-30625 Hannover, Germany.4 aut
700a Rashid, Muhammad U.u German Canc Res Ctr, Mol Genet Breast Canc, D-69120 Heidelberg, Germany.;Shaukat Khanum Mem Canc Hosp & Res Ctr SKMCH & RC, Dept Basic Sci, Lahore 54000, Pakistan.4 aut
700a Rennert, Gadu Carmel Hosp, Clalit Natl Canc Control Ctr, IL-35254 Haifa, Israel.;Technion Fac Med, IL-35254 Haifa, Israel.4 aut
700a Romero, Atochau Hosp Univ Puerta de Hierro, Med Oncol Dept, Madrid 28222, Spain.4 aut
700a Ruddy, Kathryn J.u Mayo Clin, Dept Oncol, Rochester, MN 55905 USA.4 aut
700a Ruebner, Matthiasu Friedrich Alexander Univ Erlangen Nuremberg FAU, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Dept Gynecol & Obstet, D-91054 Erlangen, Germany.4 aut
700a Saloustros, Emmanouilu Univ Hosp Larissa, Dept Oncol, Larisa 41110, Greece.4 aut
700a Sandler, Dale P.u NIEHS, Epidemiol Branch, NIH, Res Triangle Pk, NC 27709 USA.4 aut
700a Sawyer, Elinor J.u Kings Coll London, Comprehens Canc Ctr, Sch Canc & Pharmaceut Sci, Guys Campus, London, England.4 aut
700a Schmidt, Marjanka K.u Netherlands Canc Inst, Div Mol Pathol, Antoni Van Leeuwenhoek Hosp, NL-1066 CX Amsterdam, Netherlands.;Antoni Van Leeuwenhoek Hosp, Div Psychosocial Res & Epidemiol, Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands.4 aut
700a Schmutzler, Rita K.u Univ Cologne, Univ Hosp Cologne, Fac Med, Ctr Familial Breast & Ovarian Canc, D-50937 Cologne, Germany.;Univ Cologne, Univ Hosp Cologne, Fac Med, Ctr Integrated Oncol CIO, D-50937 Cologne, Germany.;Univ Cologne, Fac Med, Ctr Mol Med Cologne CMMC, D-50931 Cologne, Germany.;Univ Cologne, Univ Hosp Cologne, D-50931 Cologne, Germany.4 aut
700a Schneider, Michael O.u Friedrich Alexander Univ Erlangen Nuremberg FAU, Univ Hosp Erlangen, Comprehens Canc Ctr Erlangen EMN, Dept Gynecol & Obstet, D-91054 Erlangen, Germany.4 aut
700a Scott, Christopheru Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA.4 aut
700a Shah, Mitulu Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.4 aut
700a Sharma, Priyankau Univ Kansas Med Ctr, Dept Internal Med, Div Med Oncol, Westwood, KS 66205 USA.4 aut
700a Shen, Chen-Yangu Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan.;China Med Univ, Sch Publ Hlth, Taichung, Taiwan.4 aut
700a Shu, Xiao-Ouu Vanderbilt Univ, Vanderbilt Epidemiol Ctr, Vanderbilt Ingram Canc Ctr, Dept Med,Sch Med, Nashville, TN 37232 USA.4 aut
700a Simard, Jacquesu Ctr Hosp Univ Quebec Univ Laval Res Ctr, Genom Ctr, Quebec City, PQ G1V 4G2, Canada.4 aut
700a Surowy, Haraldu German Canc Res Ctr, Mol Epidemiol Grp, C08069120, Heidelberg, Germany.;Heidelberg Univ, Univ Womens Clin Heidelberg, Mol Biol Breast Canc, D-69120 Heidelberg, Germany.4 aut
700a Tamimi, Rulla M.u Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Weill Cornell Med, Dept Populat Hlth Sci, New York, NY 10065 USA.4 aut
700a Tapper, William J.u Univ Southampton, Fac Med, Southampton SO17 1BJ, Hants, England.4 aut
700a Taylor, Jack A.u NIEHS, Epidemiol Branch, NIH, Res Triangle Pk, NC 27709 USA.;NIEHS, Epigenet & Stem Cell Biol Lab, NIH, Res Triangle Pk, NC 27709 USA.4 aut
700a Teo, Soo Hwangu Canc Res Malaysia, Breast Canc Res Programme, Subang Jaya 47500, Selangor, Malaysia.;Univ Malaya, Fac Med, Dept Surg, Kuala Lumpur 50603, Malaysia.4 aut
700a Teras, Lauren R.u Amer Canc Soc, Dept Populat Sci, Atlanta, GA 30303 USA.4 aut
700a Toland, Amanda E.u Ohio State Univ, Dept Canc Biol & Genet, Columbus, OH 43210 USA.4 aut
700a Tollenaar, Rob A. E. M.u Leiden Univ Med Ctr, Dept Surg, NL-2333 ZA Leiden, Netherlands.4 aut
700a Torres, Dianau German Canc Res Ctr, Mol Genet Breast Canc, D-69120 Heidelberg, Germany.;Pontificia Univ Javeriana, Inst Human Genet, Bogota 110231, Colombia.4 aut
700a Torres-Mejia, Gabrielau Ctr Populat Hlth Res, Natl Inst Publ Hlth, Cuernavaca 62100, Morelos, Mexico.4 aut
700a Troester, Melissa A.u Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.;Univ North Carolina Chapel Hill, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA.4 aut
700a Truong, Thereseu Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP, INSERM, Team Exposome & Hered, F-94805 Villejuif, France.4 aut
700a Vachon, Celine M.u Mayo Clin, Div Epidemiol, Dept Quantitat Hlth Sci, Rochester, MN 55905 USA.4 aut
700a Vijai, Josephu Mem Sloan Kettering Canc Ctr, Dept Canc Biol & Genet, Clin Genet Res Lab, New York, NY 10065 USA.;Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, New York, NY 10065 USA.4 aut
700a Weinberg, Clarice R.u NIEHS, Biostat & Computat Biol Branch, NIH, Res Triangle Pk, NC 27709 USA.4 aut
700a Wendt, Camillau Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, S-11883 Stockholm, Sweden.4 aut
700a Winqvist, Robertu Univ Oulu, Bioctr Oulu, Canc & Translat Med Res Unit, Lab Canc Genet & Tumor Biol, Oulu 90570, Finland.;Northern Finland Lab Ctr Oulu, Lab Canc Genet & Tumor Biol, Oulu 90570, Finland.4 aut
700a Wolk, Alicjau Uppsala universitet,Institutionen för kirurgiska vetenskaper,Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden.4 aut0 (Swepub:uu)alwol516
700a Wu, Anna H.u Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.4 aut
700a Yamaji, Taikiu Natl Canc Ctr Inst Canc Control, Ctr Publ Hlth Sci, Div Epidemiol, Tokyo 1040045, Japan.4 aut
700a Yang, Xiaohong R.u NCI, Div Canc Epidemiol & Genet, US Dept HHS, NIH, Bethesda, MD 20850 USA.4 aut
700a Yu, Jyh-Cherngu Triserv Gen Hosp, Natl Def Med Ctr, Dept Surg, Taipei 114, Taiwan.4 aut
700a Zheng, Weiu Vanderbilt Univ, Vanderbilt Epidemiol Ctr, Vanderbilt Ingram Canc Ctr, Dept Med,Sch Med, Nashville, TN 37232 USA.4 aut
700a Ziogas, Argyriosu Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Med, Irvine, CA 92617 USA.4 aut
700a Ziv, Eladu Univ Calif San Francisco, Diller Family Comprehens Canc Ctr, Inst Human Genet, Dept Med, San Francisco, CA 94115 USA.4 aut
700a Dunning, Alison M.u Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.4 aut
700a Easton, Douglas F.u Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England.;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.4 aut
700a Hemingway, Harryu UCL, Inst Hlth Informat, London, England.;UCL, Hlth Data Res UK, London, England.;Univ Coll London Hosp, Biomed Res Ctr UCLH BRC, London, England.;Alan Turing Inst, London, England.4 aut
700a Hamann, Uteu German Canc Res Ctr, Mol Genet Breast Canc, D-69120 Heidelberg, Germany.4 aut
700a Kuchenbaecker, Karoline B.u UCL, Div Psychiat, London, England.;UCL, UCL Genet Inst, London, England.4 aut
710a UCL, Inst Hlth Informat, London, England.b University College London4 org
773t Genome Medicined : BioMed Central (BMC)g 15q 15x 1756-994Xx 1756-994X
856u https://doi.org/10.1186/s13073-022-01152-5y Fulltext
856u https://uu.diva-portal.org/smash/get/diva2:1745196/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856u http://dx.doi.org/10.1186/s13073-022-01152-5x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-498948
8564 8u https://doi.org/10.1186/s13073-022-01152-5
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:152000895
8564 8u https://lup.lub.lu.se/record/03b290d6-d650-490a-9e52-2fcb867a25b3

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