(WFRF:(Bergström Göran)) srt2:(1995-1999) conttype:(refereed)
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Labelling of polysaccharides using [11C]cyanogen bromide : In vivo and in vitro evaluation of 11C-hyaluronan uptake kinetics
- Westerberg, Göran (author)
- Bergström, Mats (author)
- Gustafson, Stefan (author)
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- Långström, Bengt (author)
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- (creator_code:org_t)
- 1995
- 1995
- English.
- In: Nuclear Medicine and Biology. - 0969-8051 .- 1872-9614. ; 22:2, s. 251-256
- Journal article (peer-reviewed)
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- A method for the 11C-labelling of polysaccharides in high specific radioactivity is described. Dextran and hyaluronan were treated with [11C]cyanogen bromide in aqueous solution at pH 11.5 to give 30-47% radiochemical yields with higher than 98% radiochemical purity in synthesis times of 24-26 min counted from the end of bombardment. Specific radioactivities at the end of synthesis ranged from 0.12 to 3.1 Ci/mumol. The biodistribution kinetics of [11C]hyaluronan injected intravenously was studied in rats by means of positron emission tomography, showing a rapid and displaceable uptake in liver. Uptake and displacement of [11C]hyaluronan was also demonstrated in cultured rat liver endothelial cells.
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- MEDICIN
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